FBXO21 and CNTNAP4

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
HPRD (two hybrid)

		FBXO21	CNTNAP4
Description		F-box protein 21	contactin associated protein family member 4
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytosol	Plasma Membrane Membrane Presynaptic Membrane Cell Projection Synapse
	Molecular Function	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding	Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Cytokine-mediated Signaling Pathway Hematopoietic Stem Cell Differentiation Hematopoietic Stem Cell Homeostasis ERK1 And ERK2 Cascade	Cell Adhesion Regulation Of Synaptic Transmission, Dopaminergic Regulation Of Synaptic Transmission, GABAergic Regulation Of Grooming Behavior
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Neurociticism ( 29500382)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Cerebrospinal T-tau levels ( 28247064) Fasting plasma glucose ( 32682390) High density lipoprotein cholesterol levels ( 33339817) Immune response to measles-mumps-rubella vaccine ( 24811271) Response to amphetamines ( 22952603) Response to haloperidol in schizophrenia ( 29503163) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Smoking status (ever vs never smokers) ( 30643258) Sphingolipid levels ( 22359512) Weight ( 34074324)
Interacting Genes		4 interacting genes: ABCB1 CNTNAP4 PIK3R1 UBC	6 interacting genes: APBA1 CASK FBXO21 MACF1 MAST3 RANBP10
Entrez ID		23014	85445
HPRD ID		09948	13079
Ensembl ID		ENSG00000135108	ENSG00000152910
Uniprot IDs		O94952 Q4G104 Q8IUQ5	A0A087WTA1 Q86YZ8 Q9C0A0
PDB IDs			4NXQ
Enriched GO Terms of Interacting Partners?		D-serine Catabolic Process Glycine Oxidase Activity D-amino-acid Dehydrogenase Activity D-alanine Catabolic Process Leukocyte Mediated Cytotoxicity Cellular Response To Nonylphenol Response To Quercetin Cellular Response To Borneol Response To Codeine Daunorubicin Transport Positive Regulation Of Establishment Of Sertoli Cell Barrier D-serine Metabolic Process D-amino Acid Catabolic Process D-amino-acid Oxidase Activity Cellular Response To External Biotic Stimulus Response To Antineoplastic Agent Response To Cyclosporin A Cellular Response To Mycotoxin Positive Regulation Of Response To Drug Leukocyte Mediated Immunity Phosphatidylethanolamine Flippase Activity Response To Flavonoid Ceramide Floppase Activity Ceramide Translocation Negative Regulation Of Sensory Perception Of Pain Kinase Regulator Activity Perinuclear Endoplasmic Reticulum Membrane Regulation Of Grooming Behavior D-amino Acid Metabolic Process Neutrophil-mediated Killing Of Gram-negative Bacterium Mitochondrial Outer Membrane L-proline Catabolic Process Cell Killing Response To Thyroxine Protein Localization To Bicellular Tight Junction Regulation Of Chloride Transport External Side Of Apical Plasma Membrane Hyperosmotic Salinity Response Xenobiotic Transport Across Blood-brain Barrier Cellular Hyperosmotic Salinity Response Floppase Activity Sphingolipid Translocation Response To Mycotoxin Phosphatidylcholine Floppase Activity Carboxylic Acid Transmembrane Transporter Activity Terpenoid Transport Response To L-phenylalanine Derivative Establishment Of Blood-retinal Barrier Insulin Binding 1-phosphatidylinositol-3-kinase Regulator Activity
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