FBXO21

Description		F-box protein 21
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytosol
	Molecular Function	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Cytokine-mediated Signaling Pathway Hematopoietic Stem Cell Differentiation Hematopoietic Stem Cell Homeostasis ERK1 And ERK2 Cascade
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Neurociticism ( 29500382)
Novel Interacting Genes		1 novel interacting genes: DAO
Interacting Genes		4 interacting genes: ABCB1 CNTNAP4 PIK3R1 UBC
Entrez ID		23014
HPRD ID		09948
Ensembl ID		ENSG00000135108
Uniprot IDs		O94952 Q4G104 Q8IUQ5
PDB IDs
Enriched GO Terms of Interacting Partners?		D-serine Catabolic Process Glycine Oxidase Activity D-amino-acid Dehydrogenase Activity D-alanine Catabolic Process Leukocyte Mediated Cytotoxicity Cellular Response To Nonylphenol Response To Quercetin Cellular Response To Borneol Response To Codeine Daunorubicin Transport Positive Regulation Of Establishment Of Sertoli Cell Barrier D-serine Metabolic Process D-amino Acid Catabolic Process D-amino-acid Oxidase Activity Cellular Response To External Biotic Stimulus Response To Antineoplastic Agent Response To Cyclosporin A Cellular Response To Mycotoxin Positive Regulation Of Response To Drug Leukocyte Mediated Immunity Phosphatidylethanolamine Flippase Activity Response To Flavonoid Ceramide Floppase Activity Ceramide Translocation Negative Regulation Of Sensory Perception Of Pain Kinase Regulator Activity Perinuclear Endoplasmic Reticulum Membrane Regulation Of Grooming Behavior D-amino Acid Metabolic Process Neutrophil-mediated Killing Of Gram-negative Bacterium Mitochondrial Outer Membrane L-proline Catabolic Process Cell Killing Response To Thyroxine Protein Localization To Bicellular Tight Junction Regulation Of Chloride Transport External Side Of Apical Plasma Membrane Hyperosmotic Salinity Response Xenobiotic Transport Across Blood-brain Barrier Cellular Hyperosmotic Salinity Response Floppase Activity Sphingolipid Translocation Response To Mycotoxin Phosphatidylcholine Floppase Activity Carboxylic Acid Transmembrane Transporter Activity Terpenoid Transport Response To L-phenylalanine Derivative Establishment Of Blood-retinal Barrier Insulin Binding 1-phosphatidylinositol-3-kinase Regulator Activity
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