PGAM1 and DCTN1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		PGAM1	DCTN1
Gene Name		phosphoglycerate mutase 1 (brain)	dynactin 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Membrane Extracellular Vesicular Exosome	Kinetochore Spindle Pole Cytoplasm Centrosome Cytosol Dynactin Complex Microtubule Membrane Dynein Complex Retromer Complex Cell Leading Edge
	Molecular Function	Bisphosphoglycerate Mutase Activity Bisphosphoglycerate 2-phosphatase Activity Phosphoglycerate Mutase Activity Protein Binding Protein Kinase Binding	Motor Activity Protein Binding Dynein Binding
	Biological Process	Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Glycolytic Process Regulation Of Glycolytic Process Pathogenesis Dephosphorylation Regulation Of Pentose-phosphate Shunt Small Molecule Metabolic Process Respiratory Burst	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Organelle Organization Mitotic Nuclear Division Nervous System Development Microtubule-based Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Endoplasmic Reticulum Unfolded Protein Response Melanosome Transport Retrograde Transport, Endosome To Golgi Cellular Protein Metabolic Process
Pathways		Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Glycolysis Metabolism of carbohydrates	IRE1alpha activates chaperones MHC class II antigen presentation XBP1(S) activates chaperone genes Unfolded Protein Response (UPR) Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: ARL4D DCTN1 PCNA PKP4 XRCC6	42 interactors: ACTR1A ACTR1B AKT1 APEX1 BBS1 BBS4 BICD1 BICD2 CASP2 CASP3 CASP7 CDC37 CLIP1 DCTN3 DISC1 DST DTNBP1 DYNC1I2 FBXL5 GRB2 GSK3B HAP1 KIAA0408 KIF11 MAP2K3 MAP2K6 MAPRE1 MED14 MTERF1 NEK2 PAFAH1B1 PFDN1 PGAM1 PPP1CA RAB6A RBL2 RPGR SEC23A SPTBN2 STAT1 VIM ZNF512B
Entrez ID		5223	1639
HPRD ID		01392	07206
Ensembl ID		ENSG00000171314	ENSG00000204843
Uniprot IDs		P18669 Q6FHU2	Q14203 Q6MZZ3
PDB IDs		1LJD 1YFK 1YJX 4GPI 4GPZ	1TXQ 2COY 2HKN 2HKQ 2HL3 2HL5 2HQH 3E2U 3TQ7
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Nuclease Activity Telomere Maintenance Positive Regulation Of Deoxyribonuclease Activity Leading Strand Elongation Cellular Hyperosmotic Salinity Response Positive Regulation Of Hydrolase Activity DNA Recombination Cellular Response To X-ray Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Establishment Of Integrated Proviral Latency Establishment Of Viral Latency Cellular Hyperosmotic Response Hyperosmotic Salinity Response Positive Regulation Of Metabolic Process Translesion Synthesis Cellular Response To Stress Cellular Response To Salt Stress Positive Regulation Of Catalytic Activity DNA Ligation Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Postreplication Repair Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Hyperosmotic Response Nuclear DNA Replication Telomere Maintenance Via Recombination DNA Repair V(D)J Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Cellular Response To Osmotic Stress DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Melanosome Transport Response To X-ray Pigment Granule Transport Establishment Of Melanosome Localization Mitotic Cell Cycle Process Positive Regulation Of Cytokinesis Melanosome Localization Response To Salt Stress Transcription-coupled Nucleotide-excision Repair Regulation Of Catalytic Activity Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cellular Response To DNA Damage Stimulus Regulation Of Cytokinesis	Cell Cycle Microtubule-based Process Organelle Organization Cell Cycle Process Mitotic Cell Cycle Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Microtubule-based Movement Microtubule-based Transport Regulation Of Cell Cycle Cytoskeleton-dependent Intracellular Transport Minus-end-directed Organelle Transport Along Microtubule Movement Of Cell Or Subcellular Component Mitotic Cell Cycle Process Regulation Of Microtubule-based Process Antigen Processing And Presentation Organelle Transport Along Microtubule Immune System Process Microtubule Cytoskeleton Organization G2/M Transition Of Mitotic Cell Cycle Regulation Of Cellular Component Organization Antigen Processing And Presentation Of Peptide Antigen Intracellular Transport Execution Phase Of Apoptosis Cellular Protein Localization Cytoskeleton Organization Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Protein Localization Cellular Localization Microtubule Anchoring At Microtubule Organizing Center Neurotrophin TRK Receptor Signaling Pathway Regulation Of Metabolic Process Neurotrophin Signaling Pathway Regulation Of Organelle Organization Establishment Of Localization In Cell Protein Localization To Cytoskeleton Cell Division Generation Of Neurons Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Cilium Assembly Organelle Assembly Neurogenesis Mitotic Nuclear Division Anatomical Structure Development Regulation Of Cell Projection Organization Nervous System Development Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle Process
Tagcloud ?		acly anabolism bioenergetic bioenergetics chemoresistance clarified clearer complexified concepts dialog dysfunctional facets flexibility glutamine hk2 ldha likewise microenvironmental modulators mycn oncometabolites owing progressed proof remodel stroma symbiosis translated warburg	als2 c147r causative chmp2b dao diagnose f21c faces fig4 g148d g59r got haloplex optn pedigree pfn1 probands sanger segregate setx sigmar1 sod1 spg11 sqstm1 synonymous tardbp ubqln2 vapb vcp
Tagcloud (Difference) ?		acly anabolism bioenergetic bioenergetics chemoresistance clarified clearer complexified concepts dialog dysfunctional facets flexibility glutamine hk2 ldha likewise microenvironmental modulators mycn oncometabolites owing progressed proof remodel stroma symbiosis translated warburg	als2 c147r causative chmp2b dao diagnose f21c faces fig4 g148d g59r got haloplex optn pedigree pfn1 probands sanger segregate setx sigmar1 sod1 spg11 sqstm1 synonymous tardbp ubqln2 vapb vcp
Tagcloud (Intersection) ?