PGAM1 and UNC5CL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PGAM1	UNC5CL
Description		phosphoglycerate mutase 1	unc-5 family C-terminal like
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Cytoplasm Centrosome Cytosol Membrane
	Molecular Function	Catalytic Activity Bisphosphoglycerate Mutase Activity Phosphoglycerate Mutase Activity Protein Binding Hydrolase Activity Isomerase Activity Intramolecular Phosphotransferase Activity Protein Kinase Binding	Netrin Receptor Activity Protein Binding Peptidase Activity
	Biological Process	Gluconeogenesis Glycolytic Process Canonical Glycolysis	Signal Transduction Netrin-activated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of JNK Cascade
Pathways		Neutrophil degranulation Glycolysis Gluconeogenesis
Drugs		Copper Artenimol
Diseases
GWAS			Alzheimer's disease or family history of Alzheimer's disease ( 33589840) Esophageal cancer ( 21642993) Gastric cancer ( 26129866) Non-cardia gastric cancer ( 26129866) Urate levels ( 31578528)
Interacting Genes		8 interacting genes: ARL4D CEBPA DCTN1 ERBB2 PCNA PKP4 UNC5CL XRCC6	7 interacting genes: KRTAP13-2 KRTAP6-1 NFKB1 PGAM1 RELA TOX2 ZMYND12
Entrez ID		5223	222643
HPRD ID		01392	09844
Ensembl ID		ENSG00000171314	ENSG00000124602
Uniprot IDs		B7Z9E5 P18669 Q6FHU2	H8YHX0 Q8IV45
PDB IDs		1YFK 1YJX 4GPI 4GPZ 5Y2I 5Y2U 5Y35 5Y64 5Y65 5ZRM 5ZS8 6ISN 7XB7 7XB8 7XB9 8IT4 8IT5 8IT6 8IT7 8IT8 8ITB 8ITC 8ITD
Enriched GO Terms of Interacting Partners?		Protein-containing Complex Binding Cellular Response To Xenobiotic Stimulus Animal Organ Regeneration RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Dexamethasone Neuromuscular Junction Development Positive Regulation Of Catalytic Activity Receptor Tyrosine Kinase Binding Damaged DNA Binding PCNA Complex Replisome CHOP-C/EBP Complex Negative Regulation Of Hemopoiesis Regulation Of Hemopoiesis Regeneration Response To Vitamin B2 White Fat Cell Proliferation Liver Development Response To Glucocorticoid Response To Corticosteroid C/EBP Complex Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Cell Cortex Region Mitotic Spindle Positive Regulation Of Neuromuscular Junction Development Spindle Pole Cell Junction Organization Negative Regulation Of Immature T Cell Proliferation In Thymus RNA Polymerase I Core Binding Positive Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity ErbB-3 Class Receptor Binding ERBB3:ERBB2 Complex Regulation Of Catalytic Activity Immature T Cell Proliferation In Thymus Regulation Of Rho Protein Signal Transduction ERBB2-ERBB4 Signaling Pathway DNA End Binding Cellular Hyperosmotic Salinity Response Telomere Maintenance DNA-dependent Protein Kinase Complex Ku70:Ku80 Complex Telomere Organization Positive Regulation Of Deoxyribonuclease Activity PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Leading Strand Elongation	NF-kappaB P50/p65 Complex Cellular Response To Nicotine Cellular Response To Angiotensin Actinin Binding Cellular Response To Interleukin-6 Response To Interleukin-6 Response To Muscle Stretch Response To Angiotensin Non-canonical NF-kappaB Signal Transduction Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Cytokine Production Involved In Inflammatory Response Response To Nicotine Transcription Coactivator Binding Tumor Necrosis Factor-mediated Signaling Pathway Canonical NF-kappaB Signal Transduction Positive Regulation Of MiRNA Metabolic Process Regulation Of Interleukin-12 Production Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of MiRNA Metabolic Process Chromatin DNA Binding Cellular Response To Tumor Necrosis Factor Response To Tumor Necrosis Factor Positive Regulation Of Hyaluronan Biosynthetic Process Secretory Granule Lumen I-kappaB/NF-kappaB Complex Phosphoglycerate Mutase Activity Bisphosphoglycerate Mutase Activity Positive Regulation Of Schwann Cell Differentiation Response To Cobalamin Negative Regulation Of Vitamin D Biosynthetic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Regulation Of Schwann Cell Differentiation NF-kappaB Complex Prolactin Signaling Pathway Intermediate Filament Mammary Gland Involution Postsynapse To Nucleus Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Response To Mechanical Stimulus Regulation Of Hyaluronan Biosynthetic Process Ankyrin Repeat Binding Cellular Response To Peptidoglycan Cellular Response To Interleukin-17 Intramolecular Phosphotransferase Activity Transcription Regulator Complex Regulation Of Vitamin Metabolic Process Defense Response To Tumor Cell Negative Regulation Of Protein Sumoylation
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