VWC2 and GET3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		VWC2	GET3
Description		von Willebrand factor C domain containing 2	guided entry of tail-anchored proteins factor 3, ATPase
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Interstitial Matrix Extracellular Space Extracellular Matrix AMPA Glutamate Receptor Complex Synapse Extrinsic Component Of Postsynaptic Membrane Glutamatergic Synapse	Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane GET Complex Extracellular Exosome
	Molecular Function	Molecular_function Protein Binding	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Membrane Insertase Activity Metal Ion Binding
	Biological Process	Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Neuron Differentiation Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane	Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Protein Insertion Into ER Membrane Tail-anchored Membrane Protein Insertion Into ER Membrane
Pathways			Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs			ATP
Diseases
GWAS		Age at first birth ( 34211149) Blood protein levels ( 30072576) Body mass index ( 25673413 28892062) Lung cancer in never smokers ( 28604730) Neurological blood protein biomarker levels ( 31320639) Post bronchodilator FEV1/FVC ratio ( 26634245) Pursuit maintenance gain ( 29064472) Serum thyroid-stimulating hormone levels ( 25436638) tricyclic pyrone compound response (IC50) ( 33610756)
Interacting Genes		57 interacting genes: ABHD15 ADAMTSL4 ATPAF2 CAMLG CATSPER1 CNNM3 CRY2 CYSRT1 ENKD1 FAM90A1 FBXW5 FUCA2 GET3 GNE HAPLN2 HOXA1 HPCA HPCAL1 KANK2 KPRP KRTAP10-8 KRTAP13-2 KRTAP13-3 KRTAP2-3 KRTAP2-4 KRTAP5-9 LCE1A LCE1C LCE1F LCE2C LCE2D LCE3A LCE3D LCE3E LCE4A LCE5A NTM OTX1 PFKFB1 POU4F2 PRPF31 SCNM1 SGTB SHFL SPRY1 TRAPPC14 UBQLN1 UBQLN2 VASN YY1 ZNF319 ZNF417 ZNF490 ZNF497 ZNF587 ZNF774 ZNF837	38 interacting genes: AGR2 APLN ASPH CACNA1A CREB3L4 EMSY FAM209A FKBP7 GOLM1 GPX7 GPX8 HILPDA IGFBP6 KCNE4 KCNE5 LDLRAD4 PDIA6 PEX14 PFDN1 PGRMC1 PGRMC2 PRB3 PRR4 RHEX SEC61A1 SEC61B SMIM19 SPP1 STATH SYPL2 TK1 TMEM154 TMEM51 TMX1 TTR VAMP2 VWC2 WFDC3
Entrez ID		375567	439
HPRD ID		18271	03555
Ensembl ID		ENSG00000188730	ENSG00000198356
Uniprot IDs		Q2TAL6	O43681
PDB IDs			6SO5 8CQZ 8CR1 8CR2
Enriched GO Terms of Interacting Partners?		Epidermis Development Keratinization Tissue Development Protein Binding Intermediate Filament GET Complex Identical Protein Binding Keratin Filament	Extracellular Region Endoplasmic Reticulum Lumen Intracellular Protein Transmembrane Transport Body Fluid Secretion Sec61 Translocon Complex SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Post-translational Protein Targeting To Membrane, Translocation Endoplasmic Reticulum Extracellular Space Regulation Of Body Fluid Levels Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Ventricular Cardiac Muscle Cell Membrane Repolarization Mucus Secretion Potassium Ion Export Across Plasma Membrane Protein Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Voltage-gated Potassium Channel Complex Regulation Of Heart Contraction Amyloid-beta Binding Glutathione Peroxidase Activity Protein Disulfide Isomerase Activity Membrane Repolarization During Cardiac Muscle Cell Action Potential Delayed Rectifier Potassium Channel Activity Membrane Repolarization During Action Potential Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Protein Binding Regulation Of System Process Protein-disulfide Reductase Activity
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