PEX6 and CERS2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PEX6	CERS2
Gene Name		peroxisomal biogenesis factor 6	ceramide synthase 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Peroxisome Peroxisomal Membrane Cytosol	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Nuclear Membrane
	Molecular Function	Protein Binding ATP Binding Protein C-terminus Binding ATPase Activity Protein Complex Binding ATPase Activity, Coupled	DNA Binding Protein Binding Sphingosine N-acyltransferase Activity
	Biological Process	Protein Targeting To Peroxisome Peroxisome Organization Metabolic Process Protein Import Into Peroxisome Matrix, Translocation Protein Stabilization	Sphingolipid Metabolic Process Sphingolipid Biosynthetic Process Small Molecule Metabolic Process Ceramide Biosynthetic Process
Pathways			Sphingolipid metabolism Metabolism of lipids and lipoproteins Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS			Rhegmatogenous retinal detachment ( 23585552)
Protein-Protein Interactions		7 interactors: ATF7IP CERS2 PEX1 PEX26 RPL27A RPS14 SMAD3	9 interactors: ASGR1 ASGR2 ATP6V0C HSP90AA1 PEX6 SLC19A2 SLC22A1 SLC39A1 TMBIM6
Entrez ID		5190	29956
HPRD ID		03293	06080
Ensembl ID		ENSG00000124587	ENSG00000143418
Uniprot IDs		Q13608 Q8WYQ1	Q96G23
PDB IDs
Enriched GO Terms of Interacting Partners?		Establishment Of Protein Localization To Organelle Protein Targeting Protein Import Into Peroxisome Matrix Protein Localization To Organelle Viral Process Protein Targeting To Membrane Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Cytoplasmic Transport Establishment Of Protein Localization To Membrane Intracellular Protein Transport Peroxisome Organization Intracellular Protein Transmembrane Transport Protein Localization To Membrane Protein Transmembrane Transport Viral Transcription Positive Regulation Of Transforming Growth Factor Beta3 Production Cellular Protein Localization Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Protein Targeting To ER Protein Transport Establishment Of Protein Localization To Endoplasmic Reticulum Establishment Of Protein Localization Intracellular Transport Protein Localization To Endoplasmic Reticulum Microtubule-based Peroxisome Localization Translational Termination Nuclear-transcribed MRNA Catabolic Process Evasion Or Tolerance Of Host Defenses By Virus Protein Import MRNA Catabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Translational Elongation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly RNA Catabolic Process Protein Localization Cellular Protein Complex Disassembly Viral Life Cycle Regulation Of Extracellular Matrix Assembly Establishment Of Localization In Cell Membrane Organization Protein Complex Disassembly Regulation Of Gene Expression, Epigenetic Protein Import Into Peroxisome Membrane Primary MiRNA Processing Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Peroxisomal Membrane Transport	Transmembrane Transport Transport Drug Transmembrane Transport Drug Transport Intracellular Protein Transmembrane Transport Protein Transmembrane Transport Receptor-mediated Endocytosis Epinephrine Transport Response To Unfolded Protein Protein Import Into Peroxisome Matrix, Translocation Acetate Ester Transport Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Regulation Of Protein Stability Protein Import Into Mitochondrial Outer Membrane Norepinephrine Transport Protein Import Endocytosis Thiamine Transmembrane Transport Thiamine Transport Thiamine-containing Compound Metabolic Process Ion Transport Folic Acid Transport Chemical Homeostasis Dopamine Transport Cation Transmembrane Transport Chaperone-mediated Protein Complex Assembly Protein Import Into Peroxisome Matrix Pyrimidine-containing Compound Transmembrane Transport Quaternary Ammonium Group Transport Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Establishment Of Protein Localization To Organelle Protein Refolding Vitamin Transmembrane Transport Cation Transport Zinc Ion Transmembrane Transport Cellular Metal Ion Homeostasis Monoamine Transport Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Response To Stimulus Protein Targeting Ion Transmembrane Transport Nitric Oxide Metabolic Process Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Cation Homeostasis Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Cellular Response To Heat Cellular Ion Homeostasis Reactive Nitrogen Species Metabolic Process Posttranscriptional Regulation Of Gene Expression
Tagcloud ?		aat2 aptamer bacteriophage colocalization dci1 gpd1 importation mdh3 mpps ms2 nonperoxisomal npy1 organellar pcd1 pcs60 peroxisomal peroxisomes pex1 pex11 pex14 pex28 pex3 pex5 pex7 pex8 pox1 puf5 rbp rfp	17beta ceramide ceramides cers4 cers5 cers6 clarify constructs dimerization erbeta estradiol fos fulvestrant fumonisin gper1 investigating lengths luc luciferase mcf pathophysiological plasmids posttranscriptional processess promoters sphingolipid synthases utr
Tagcloud (Difference) ?		aat2 aptamer bacteriophage colocalization dci1 gpd1 importation mdh3 mpps ms2 nonperoxisomal npy1 organellar pcd1 pcs60 peroxisomal peroxisomes pex1 pex11 pex14 pex28 pex3 pex5 pex7 pex8 pox1 puf5 rbp rfp	17beta ceramide ceramides cers4 cers5 cers6 clarify constructs dimerization erbeta estradiol fos fulvestrant fumonisin gper1 investigating lengths luc luciferase mcf pathophysiological plasmids posttranscriptional processess promoters sphingolipid synthases utr
Tagcloud (Intersection) ?