PEX6 and PEX1

Number of citations of the paper that reports this interaction (PubMedID 9671729)
25

Data Source:
BioGRID (two hybrid, pull down)
HPRD (two hybrid, in vitro)

		PEX6	PEX1
Description		peroxisomal biogenesis factor 6	peroxisomal biogenesis factor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Membrane Cell Projection Photoreceptor Cell Cilium	Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein-containing Complex Binding Ubiquitin-modified Protein Reader Activity Protein Transporter Activity	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein-containing Complex Binding Ubiquitin-modified Protein Reader Activity Protein Transporter Activity
	Biological Process	Protein Targeting To Peroxisome Peroxisome Organization Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Protein Stabilization	Protein Targeting To Peroxisome Peroxisome Organization Protein Transport Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Microtubule-based Peroxisome Localization
Pathways		Peroxisomal protein import Peroxisomal protein import	Peroxisomal protein import Peroxisomal protein import
Drugs
Diseases		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)	Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Alzheimer's disease in APOE e4+ carriers ( 25778476) Hematocrit ( 32888494) Red blood cell count ( 32888494)	Height ( 18391951) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		8 interacting genes: ATF7IP CERS2 PEX1 PEX26 PEX5 RPL27A RPS14 SMAD3	3 interacting genes: PEX26 PEX5 PEX6
Entrez ID		5190	5189
HPRD ID		03293	03682
Ensembl ID		ENSG00000124587	ENSG00000127980
Uniprot IDs		Q13608	A0A0C4DG33 B4DER6 O43933
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Establishment Of Protein Localization To Peroxisome Peroxisomal Membrane Transport Peroxisome Organization Receptor Recycling Intracellular Protein Transmembrane Transport Receptor Metabolic Process Protein Import Into Peroxisome Membrane Peroxisomal Membrane Protein Transmembrane Transport Protein Targeting To Peroxisome Peroxisome Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Negative Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration Cytosol Establishment Of Protein Localization To Organelle Positive Regulation Of Transforming Growth Factor Beta3 Production Microtubule-based Peroxisome Localization Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Cytosolic Ribosome Sterol Response Element Binding Paraxial Mesoderm Morphogenesis Peroxisome Targeting Sequence Binding Negative Regulation Of Schwann Cell Migration Cytoplasmic Translation Regulation Of Lung Blood Pressure Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Intracellular Protein Transport Mesoderm Morphogenesis Immune System Development Structural Constituent Of Ribosome Protein To Membrane Docking Pericardium Development Protein Import Into Peroxisome Matrix, Substrate Release Sphingosine N-acyltransferase Activity Transdifferentiation SMAD Protein Complex Trophoblast Cell Migration Regulation Of Response To Wounding Protein Localization To Organelle Negative Regulation Of Glial Cell Migration DEAD/H-box RNA Helicase Binding Heteromeric SMAD Protein Complex Regulation Of Transforming Growth Factor Beta2 Production Ribosome	Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Establishment Of Protein Localization To Peroxisome Peroxisomal Membrane Transport Peroxisome Organization Receptor Recycling Intracellular Protein Transmembrane Transport Receptor Metabolic Process Peroxisomal Membrane Protein Import Into Peroxisome Matrix, Translocation Protein Transmembrane Transport Protein Import Into Peroxisome Membrane Peroxisome Protein Targeting To Peroxisome Establishment Of Protein Localization To Organelle Intracellular Protein Transport Protein Localization To Organelle Ciliary Neurotrophic Factor Binding Hepatic Immune Response Interleukin-6 Binding Interleukin-6 Receptor Activity Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Interleukin-6 Receptor Complex Ciliary Neurotrophic Factor Receptor Complex Peroxisome Targeting Sequence Binding Ciliary Neurotrophic Factor Receptor Activity Interleukin-11 Receptor Activity Interleukin-11 Binding Protein Targeting Protein Transport Establishment Of Protein Localization To Membrane Protein Import Into Peroxisome Matrix, Docking Transmembrane Transport Ciliary Neurotrophic Factor-mediated Signaling Pathway Protein To Membrane Docking Intracellular Transport Vascular Endothelial Growth Factor Production Protein Import Into Peroxisome Matrix, Substrate Release Interleukin-11-mediated Signaling Pathway Interleukin-6 Receptor Binding Positive Regulation Of Glomerular Mesangial Cell Proliferation Establishment Of Protein Localization Protein Localization To Membrane Positive Regulation Of Cell Proliferation Involved In Kidney Development Photoreceptor Cell Cilium Ubiquitin-modified Protein Reader Activity Protein Carrier Chaperone Protein-containing Complex Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?