GHRHR and MLNR

Number of citations of the paper that reports this interaction (PMID 12606621)
9

Data Source:
HPRD (in vivo)

		GHRHR	MLNR
Gene Name		growth hormone releasing hormone receptor	motilin receptor
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Inner Membrane Nuclear Outer Membrane Cytoplasm Plasma Membrane Cell Surface Integral Component Of Membrane Nuclear Matrix Secretory Granule	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	G-protein Coupled Receptor Activity Protein Binding Growth Hormone-releasing Hormone Receptor Activity Peptide Hormone Binding Growth Factor Binding	G-protein Coupled Receptor Activity Growth Hormone-releasing Hormone Receptor Activity
	Biological Process	Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Lactation Positive Regulation Of Cell Proliferation Determination Of Adult Lifespan CAMP-mediated Signaling Water Homeostasis Growth Hormone Secretion Positive Regulation Of CAMP Biosynthetic Process Response To Insulin Cellular Response To Insulin Stimulus Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Multicellular Organism Growth Hormone Metabolic Process Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Response To Estrogen Cell Maturation Multicellular Organismal Reproductive Process Regulation Of Protein Metabolic Process Response To Glucocorticoid Positive Regulation Of Growth Hormone Secretion Somatotropin Secreting Cell Development	G-protein Coupled Receptor Signaling Pathway Digestion
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Glucagon-type ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Sermorelin Tesamorelin
Diseases
GWAS
Protein-Protein Interactions		3 interactors: GHRH GHRL MLNR	4 interactors: GHRHR GHRL GPRASP1 MLN
Entrez ID		2692	2862
HPRD ID		00748	04197
Ensembl ID		ENSG00000106128	ENSG00000102539
Uniprot IDs		Q02643	O43193
PDB IDs		2XDG
Enriched GO Terms of Interacting Partners?		Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Growth Hormone Secretion Regulation Of Growth Hormone Secretion Growth Hormone Secretion Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Circadian Rhythm Positive Regulation Of Multicellular Organism Growth Peptide Hormone Secretion Peptide Secretion Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Hormone Secretion Hormone Transport Peptide Transport Regulation Of Circadian Rhythm Regulation Of Multicellular Organism Growth Positive Regulation Of Hormone Secretion Digestion Positive Regulation Of Behavior Amide Transport G-protein Coupled Receptor Signaling Pathway Cortisol Secretion Positive Regulation Of Developmental Growth Regulation Of Behavior Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Regulation Of Peptide Hormone Secretion Positive Regulation Of Growth Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Regulation Of Hormone Secretion Regulation Of Hormone Levels Regulation Of Developmental Growth Positive Regulation Of Cortisol Secretion Positive Regulation Of Corticotropin Secretion Positive Regulation Of Appetite Positive Regulation Of Secretion Regulation Of Corticotropin Secretion Regulation Of Growth Hormone Receptor Signaling Pathway Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Interleukin-6 Biosynthetic Process Response To Nutrient Levels Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Adult Feeding Behavior Response To Extracellular Stimulus Gastric Acid Secretion Secretion By Cell Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Adenohypophysis Development	Positive Regulation Of Growth Hormone Secretion Regulation Of Growth Hormone Secretion Growth Hormone Secretion Positive Regulation Of Multicellular Organism Growth Peptide Hormone Secretion Peptide Secretion Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Hormone Secretion Hormone Transport Peptide Transport Regulation Of Multicellular Organism Growth Positive Regulation Of Hormone Secretion Cortisol Secretion Amide Transport Cell-cell Signaling Positive Regulation Of Developmental Growth Somatotropin Secreting Cell Development Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep G-protein Coupled Receptor Catabolic Process G-protein Coupled Receptor Signaling Pathway Response To Estrogen Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Regulation Of Peptide Hormone Secretion Positive Regulation Of Growth Positive Regulation Of Cortisol Secretion Positive Regulation Of Corticotropin Secretion Positive Regulation Of Appetite Regulation Of Hormone Secretion Regulation Of Hormone Levels Regulation Of Corticotropin Secretion Regulation Of Growth Hormone Receptor Signaling Pathway Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Somatotropin Secreting Cell Differentiation Regulation Of Developmental Growth Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle, REM Sleep Negative Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of Secretion Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Adult Feeding Behavior Gastric Acid Secretion Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Establishment Of Localization In Cell Response To Steroid Hormone Adenohypophysis Development Negative Regulation Of Interleukin-1 Beta Production Secretion By Cell Regulation Of Circadian Sleep/wake Cycle, Sleep
Tagcloud ?		abeta appswe autosomal dark deprivation diurnal fluctuation interstitial intracerebroventricular intraperitoneal isf lit manipulating microdialysis neurofibrillary orexin overexpress possibilities ps1app ps1deltae9 psen1 releasing sleep substance tangles wake wakefulness
Tagcloud (Difference) ?		abeta appswe autosomal dark deprivation diurnal fluctuation interstitial intracerebroventricular intraperitoneal isf lit manipulating microdialysis neurofibrillary orexin overexpress possibilities ps1app ps1deltae9 psen1 releasing sleep substance tangles wake wakefulness
Tagcloud (Intersection) ?