CPSF3 and CLP1

Number of citations of the paper that reports this interaction (PubMedID 11060040)
42

Data Source:
HPRD (in vitro, in vivo)

		CPSF3	CLP1
Description		cleavage and polyadenylation specific factor 3	cleavage factor polyribonucleotide kinase subunit 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex Ribonucleoprotein Complex	TRNA-intron Endonuclease Complex Nucleus Nucleoplasm Cytosol MRNA Cleavage Factor Complex
	Molecular Function	RNA Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity 5'-3' RNA Exonuclease Activity Protein Binding Hydrolase Activity Metal Ion Binding	Nucleotide Binding Protein Binding ATP Binding Kinase Activity Transferase Activity ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity Polynucleotide 5'-hydroxyl-kinase Activity ATP-dependent Polynucleotide 5'-hydroxyl-kinase Activity ATP-dependent Polyribonucleotide 5'-hydroxyl-kinase Activity
	Biological Process	MRNA Processing MRNA 3'-end Processing By Stem-loop Binding And Cleavage MRNA 3'-end Processing Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	TRNA Splicing, Via Endonucleolytic Cleavage And Ligation RNA Processing MRNA Processing TRNA Processing Cerebellar Cortex Development MRNA 3'-end Processing RISC Complex Assembly Global Gene Silencing By MRNA Cleavage
Pathways		Transport of Mature mRNA Derived from an Intronless Transcript mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs	tRNA processing in the nucleus mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Drugs
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Neuroticism ( 29255261) Schizophrenia ( 25056061 29483656)
Interacting Genes		10 interacting genes: CLP1 FAM107A HSPB1 MIR19A MIR19B1 MIR92A2 PAPOLA POLR2A RBBP6 YWHAG	16 interacting genes: APP CEP164 CPSF3 CREB3 DAGLB FGF16 FTO HCFC1 MEOX2 MESD NUDT21 PCMT1 PRR3 PSMB5 SNF8 YJU2B
Entrez ID		51692	10978
HPRD ID		05825	16382
Ensembl ID		ENSG00000119203	ENSG00000172409
Uniprot IDs		G5E9W3 Q9UKF6	Q92989
PDB IDs		2I7T 2I7V 6M8Q 6V4X 8T1Q 8T1R	8HMY 8HMZ
Enriched GO Terms of Interacting Partners?		Post-transcriptional Regulation Of Gene Expression Protein Kinase C Inhibitor Activity Post-transcriptional Gene Silencing Negative Regulation Of Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Matrix Metallopeptidase Secretion Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Extracellular Matrix Assembly RISC Complex Cellular Response To Bacterial Lipopeptide Response To Bacterial Lipoprotein Negative Regulation Of Fibroblast Migration MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Extracellular Matrix Assembly Negative Regulation Of Extracellular Matrix Organization Regulatory NcRNA-mediated Gene Silencing Negative Regulation Of Inflammatory Response To Antigenic Stimulus MRNA 3'-end Processing Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Immune Response Positive Regulation Of Heart Growth Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Striated Muscle Cell Apoptotic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Regulation Of Fibroblast Migration MRNA Metabolic Process Positive Regulation Of Striated Muscle Cell Differentiation Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Epithelial To Mesenchymal Transition Protein Kinase C Binding Positive Regulation Of Organ Growth Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Interleukin-6 Production Negative Regulation Of Muscle Cell Apoptotic Process Regulation Of Metabolic Process MRNA Base-pairing Post-transcriptional Repressor Activity Negative Regulation Of Protein Kinase C Signaling Negative Regulation Of Reverse Cholesterol Transport Negative Regulation Of Apolipoprotein A-I-mediated Signaling Pathway Regulation Of Heart Growth Regulation Of Extracellular Matrix Organization Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Protein Secretion Positive Regulation Of Muscle Cell Differentiation	Release From Viral Latency Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway Co-transcriptional RNA 3'-end Processing, Cleavage And Polyadenylation Pathway MRNA Cleavage And Polyadenylation Specificity Factor Complex Positive Regulation Of Monocyte Chemotaxis Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Chemotaxis Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Chemotaxis Amylin Binding Positive Regulation Of Toll Signaling Pathway Chromatin Binding Regulation Of Monocyte Chemotaxis Positive Regulation Of Deacetylase Activity MRNA 3'-end Processing Positive Regulation Of Pro-B Cell Differentiation RNA Repair TRNA Demethylase Activity
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