CPSF3 and PAPOLA

Number of citations of the paper that reports this interaction (PMID 8302877)
22

Data Source:
HPRD (in vitro)

		CPSF3	PAPOLA
Gene Name		cleavage and polyadenylation specific factor 3, 73kDa	poly(A) polymerase alpha
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Binding Endoribonuclease Activity Protein Binding 5'-3' Exonuclease Activity Metal Ion Binding	Magnesium Ion Binding RNA Binding Polynucleotide Adenylyltransferase Activity ATP Binding Manganese Ion Binding
	Biological Process	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Polyadenylation MRNA Cleavage Histone MRNA 3'-end Processing MRNA Export From Nucleus RNA Splicing Gene Expression MRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Endonucleolytic	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription RNA Splicing Gene Expression MRNA 3'-end Processing RNA Polyadenylation
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing Transport of Mature mRNA Derived from an Intronless Transcript RNA Polymerase II Transcription Transport of Mature mRNAs Derived from Intronless Transcripts Cleavage of Growing Transcript in the Termination Region mRNA Splicing - Major Pathway mRNA 3'-end processing Processing of Intronless Pre-mRNAs Processing of Capped Intronless Pre-mRNA Transport of Mature Transcript to Cytoplasm RNA Polymerase II Transcription Termination	mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Processing of Capped Intronless Pre-mRNA mRNA Splicing - Major Pathway Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs mRNA 3'-end processing
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: CLP1 PAPOLA POLR2A YWHAG	6 interactors: CPSF1 CPSF3 RRAGA SMAD2 SNRPA YWHAE
Entrez ID		51692	10914
HPRD ID		05825	10407
Ensembl ID		ENSG00000119203	ENSG00000090060
Uniprot IDs		G5E9W3 Q9UKF6	G3XAH6 P51003
PDB IDs		2I7T 2I7V
Enriched GO Terms of Interacting Partners?		MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Polyadenylation RNA Splicing Termination Of RNA Polymerase II Transcription MRNA Processing MRNA Metabolic Process RNA Processing DNA-templated Transcription, Termination MRNA 3'-end Processing RNA 3'-end Processing Transcription From RNA Polymerase II Promoter Negative Regulation Of Protein Serine/threonine Kinase Activity SiRNA Loading Onto RISC Involved In RNA Interference Transcription, RNA-templated Carbohydrate Mediated Signaling Targeting Of MRNA For Destruction Involved In RNA Interference Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Negative Regulation Of Transferase Activity Negative Regulation Of Protein Phosphorylation Negative Regulation Of Phosphorylation NcRNA Metabolic Process RNA Interference Phagocytosis, Recognition MRNA Cleavage TRNA Splicing, Via Endonucleolytic Cleavage And Ligation Transcription, DNA-templated Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway RNA Biosynthetic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity MRNA Polyadenylation 7-methylguanosine MRNA Capping PiRNA Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of RNA Splicing 7-methylguanosine RNA Capping Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Posttranscriptional Gene Silencing Negative Regulation Of Cellular Protein Metabolic Process Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Viral Transcription Negative Regulation Of Protein Metabolic Process RNA Metabolic Process Positive Regulation Of Mitochondrion Organization Transcription Elongation From RNA Polymerase II Promoter Gene Silencing By RNA	RNA Processing MRNA Cleavage MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Polyadenylation RNA Polyadenylation Termination Of RNA Polymerase II Transcription RNA Splicing Cellular Localization MRNA Processing MRNA Export From Nucleus DNA-templated Transcription, Termination RNA Export From Nucleus MRNA 3'-end Processing MRNA Metabolic Process RNA 3'-end Processing Nuclear Export MRNA Transport Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Negative Regulation Of Peptidyl-serine Dephosphorylation Regulation Of Heart Rate By Hormone RNA Transport RNA Localization Establishment Of Localization In Cell Zygotic Specification Of Dorsal/ventral Axis Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Transcription From RNA Polymerase II Promoter Positive Regulation Of Cytolysis Histone MRNA 3'-end Processing Negative Regulation Of Protein Dephosphorylation Positive Regulation Of Mesoderm Development Primary MiRNA Processing Regulation Of Nodal Signaling Pathway Common-partner SMAD Protein Phosphorylation Nucleocytoplasmic Transport Nuclear Transport Positive Regulation Of Activin Receptor Signaling Pathway Regulation Of Heart Rate By Chemical Signal Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Nucleic Acid Phosphodiester Bond Hydrolysis Positive Regulation Of Signal Transduction SMAD Protein Complex Assembly Membrane Repolarization Paraxial Mesoderm Morphogenesis RNA Metabolic Process Nodal Signaling Pathway Intracellular Transport Gene Expression Histone MRNA Metabolic Process
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