ENPP2 and DYRK1A

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		ENPP2	DYRK1A
Description		ectonucleotide pyrophosphatase/phosphodiesterase 2	dual specificity tyrosine phosphorylation regulated kinase 1A
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Neurofilament Actin Filament Nuclear Speck Axon Dendrite Ribonucleoprotein Complex
	Molecular Function	Nucleic Acid Binding Phosphodiesterase I Activity Phosphatidylcholine Lysophospholipase Activity Phospholipase D Activity Scavenger Receptor Activity Calcium Ion Binding Zinc Ion Binding Hydrolase Activity Polysaccharide Binding Metal Ion Binding Alkylglycerophosphoethanolamine Phosphodiesterase Activity	Nucleotide Binding Transcription Coactivator Activity Actin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Cytoskeletal Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Tubulin Binding Kinase Activity Transferase Activity Identical Protein Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity Histone H3T45 Kinase Activity Splicing Factor Binding
	Biological Process	Lipid Metabolic Process Phospholipid Metabolic Process Chemotaxis Immune Response Phospholipid Catabolic Process Positive Regulation Of Epithelial Cell Migration Lipid Catabolic Process Vesicle-mediated Transport Sphingolipid Catabolic Process Regulation Of Cell Migration Phosphatidylcholine Catabolic Process Cell Motility Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Lamellipodium Morphogenesis	Regulation Of Alternative MRNA Splicing, Via Spliceosome Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Via Nonhomologous End Joining Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Nervous System Development Circadian Rhythm Peptidyl-tyrosine Phosphorylation Negative Regulation Of Microtubule Polymerization Negative Regulation Of Heterochromatin Formation Positive Regulation Of RNA Splicing Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of DNA-templated Transcription Protein Autophosphorylation Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Amyloid-beta Formation Regulation Of Neurofibrillary Tangle Assembly
Pathways		Vitamin B5 (pantothenate) metabolism	G0 and Early G1
Drugs			N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide Fostamatinib
Diseases
GWAS		Appendicular lean mass ( 33097823) Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Cortical volume ( 32963231) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 21998595 28552196 31562340) Major depressive disorder and major depressive episode treated with electroconvulsive therapy ( 33483693) Major depressive episode treated with electroconvulsive therapy ( 33483693) Offspring birth weight ( 31043758)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) HIV-1 replication ( 21364930) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 20694148) Neutrophil count ( 32888494) Parkinson's disease ( 32201043) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Stroke ( 30383316) Systolic blood pressure ( 32902719) White blood cell count ( 32888494)
Interacting Genes		3 interacting genes: DYRK1A HSPB1 LCOR	145 interacting genes: - ABCA2 ABHD12 ADAM19 ADAM22 ADAM23 ADAM9 ADAMTS1 ADAMTS9 AGAP1 AMPH APP ASTN2 ATRN ATRNL1 CACHD1 CCN1 CCNL2 CEP70 CFH CKAP5 CLASRP CLU CREB1 CRIM1 CTNNA1 CYLD DCAF5 DCHS2 DCTD DKK3 DNM1 DNM3 DROSHA DSCAM DSCAML1 DVL3 DYNLL1 EFEMP1 EFEMP2 EIF2B5 ENPP2 ERBB3 ERC1 FAM53C FBN1 FEZ1 FOXO1 GEMIN8 GLI1 GPR37L1 H2BC3 H3C1 H4C1 HMG20A ID2 ITGB8 JCAD KIF1A KPNA4 KPNA6 KPRP LAMB1 LATS2 LEO1 LIN52 LMO3 LRP1B LRP2 LRP4 LTBP3 MAGEH1 MAPT MEGF9 MIGA1 MTA1 MTA3 MYCBP2 MYT1L NAP1L1 NCAPH2 NECAB3 NELL1 NELL2 NPC1 NUCB1 OSBPL1A PCSK6 PEA15 PHYHIP PJA1 PLAUR PLP1 PNISR PRDM4 PRKN PSAP PTOV1 RAPGEF2 RB1 RBL1 RECK RNF169 RNF216 RNF220 RSBN1L SCRIB SF3B1 SMAD2 SNCA SNRNP70 SPRED1 SPRED2 SPRY2 SPTBN1 SRPK2 SRSF1 SRSF10 SRSF4 SRSF5 STAB1 STX1A SULF1 THBS1 TMEFF1 TMEM59 TNFRSF25 TRAF2 TRIM66 TROAP TSPYL2 USP13 USP32 USP34 USP54 USP7 VLDLR VPS54 WIF1 XRCC6 YWHAB YWHAE YWHAG ZBTB11 ZNF365
Entrez ID		5168	1859
HPRD ID		03037	09018
Ensembl ID		ENSG00000136960	ENSG00000157540
Uniprot IDs		E7EUF1 Q13822	A0A2R8Y6I6 Q13627
PDB IDs		4ZG6 4ZG7 4ZG9 4ZGA 5KXA 5M7M 5MHP 8C3O 8C3P	2VX3 2WO6 3ANQ 3ANR 4AZE 4MQ1 4MQ2 4NCT 4YLJ 4YLK 4YLL 4YU2 5A3X 5A4E 5A4L 5A4Q 5A4T 5A54 5AIK 6A1F 6A1G 6EIF 6EIJ 6EIL 6EIP 6EIQ 6EIR 6EIS 6EIV 6EJ4 6LN1 6QU2 6S11 6S14 6S17 6S1B 6S1H 6S1I 6S1J 6T6A 6UIP 6UWY 6YF8 7A4O 7A4R 7A4S 7A4W 7A4Z 7A51 7A52 7A53 7A55 7A5B 7A5D 7A5L 7A5N 7AJ2 7AJ4 7AJ5 7AJ7 7AJ8 7AJA 7AJM 7AJS 7AJV 7AJW 7AJY 7AK2 7AKA 7AKB 7AKE 7AKL 7FHS 7FHT 7O7K 7OY6 7Z5N 7ZH8 8C3G 8C3Q 8C3R 8R8E 8T2H 8YEV
Enriched GO Terms of Interacting Partners?		Cytoskeletal Protein Binding Histone H3T45 Kinase Activity Unfolded Protein Binding Negative Regulation Of Protein Kinase C Signaling Negative Regulation Of Heterochromatin Formation Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Regulation Of Heterochromatin Formation Positive Regulation Of Synaptic Vesicle Endocytosis Regulation Of Dopamine Uptake Involved In Synaptic Transmission Protein Folding Positive Regulation Of Synaptic Vesicle Recycling Regulation Of Protein Kinase C Signaling Anterograde Axonal Protein Transport Protein Kinase C Inhibitor Activity RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Cytoskeleton Neurofilament Protein Deneddylation Negative Regulation Of Microtubule Polymerization Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Synaptic Vesicle Membrane Organization Positive Regulation Of Endothelial Cell Chemotaxis Protein Transport Along Microtubule Contractile Muscle Fiber Histone Methyltransferase Binding Identical Protein Binding Misfolded Protein Binding	Regulation Of Developmental Process Regulation Of Cell Differentiation Regulation Of Multicellular Organismal Process Positive Regulation Of Signaling Regulation Of Multicellular Organismal Development Calcium Ion Binding Positive Regulation Of Developmental Process Positive Regulation Of Cell Communication Regulation Of Phosphorus Metabolic Process Positive Regulation Of Signal Transduction Negative Regulation Of Developmental Process Regulation Of Metabolic Process Regulation Of Phosphorylation Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Heparin Binding Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Macromolecule Metabolic Process Regulation Of Signaling Developmental Process Negative Regulation Of Lens Fiber Cell Differentiation Regulation Of Primary Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Wnt Signaling Pathway Positive Regulation Of Cell Differentiation Integrin Binding Positive Regulation Of Programmed Cell Death Low-density Lipoprotein Particle Receptor Activity Positive Regulation Of Macromolecule Metabolic Process Cell Surface Receptor Signaling Pathway Macromolecule Metabolic Process Regulation Of Protein Localization Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Extracellular Region Apolipoprotein Binding Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Phosphate Metabolic Process Response To Growth Factor Neuron Projection Morphogenesis
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