ENPP2

Description		ectonucleotide pyrophosphatase/phosphodiesterase 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane
	Molecular Function	Nucleic Acid Binding Phosphodiesterase I Activity Phosphatidylcholine Lysophospholipase Activity Phospholipase D Activity Scavenger Receptor Activity Calcium Ion Binding Zinc Ion Binding Hydrolase Activity Polysaccharide Binding Metal Ion Binding Alkylglycerophosphoethanolamine Phosphodiesterase Activity
	Biological Process	Lipid Metabolic Process Phospholipid Metabolic Process Chemotaxis Immune Response Phospholipid Catabolic Process Positive Regulation Of Epithelial Cell Migration Lipid Catabolic Process Vesicle-mediated Transport Sphingolipid Catabolic Process Regulation Of Cell Migration Phosphatidylcholine Catabolic Process Cell Motility Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Lamellipodium Morphogenesis
Pathways		Vitamin B5 (pantothenate) metabolism
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Cortical volume ( 32963231) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 21998595 28552196 31562340) Major depressive disorder and major depressive episode treated with electroconvulsive therapy ( 33483693) Major depressive episode treated with electroconvulsive therapy ( 33483693) Offspring birth weight ( 31043758)
Novel Interacting Genes		1 novel interacting genes: TOR1A
Interacting Genes		3 interacting genes: DYRK1A HSPB1 LCOR
Entrez ID		5168
HPRD ID		03037
Ensembl ID		ENSG00000136960
Uniprot IDs		E7EUF1 Q13822
PDB IDs		4ZG6 4ZG7 4ZG9 4ZGA 5KXA 5M7M 5MHP 8C3O 8C3P
Enriched GO Terms of Interacting Partners?		Cytoskeletal Protein Binding Histone H3T45 Kinase Activity Unfolded Protein Binding Negative Regulation Of Protein Kinase C Signaling Negative Regulation Of Heterochromatin Formation Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Regulation Of Heterochromatin Formation Positive Regulation Of Synaptic Vesicle Endocytosis Regulation Of Dopamine Uptake Involved In Synaptic Transmission Protein Folding Positive Regulation Of Synaptic Vesicle Recycling Regulation Of Protein Kinase C Signaling Anterograde Axonal Protein Transport Protein Kinase C Inhibitor Activity RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Cytoskeleton Neurofilament Protein Deneddylation Negative Regulation Of Microtubule Polymerization Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Synaptic Vesicle Membrane Organization Positive Regulation Of Endothelial Cell Chemotaxis Protein Transport Along Microtubule Contractile Muscle Fiber Histone Methyltransferase Binding Identical Protein Binding Misfolded Protein Binding
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