PDK3 and PDHA1

Number of citations of the paper that reports this interaction (PMID 12676647)
68

Data Source:
HPRD (in vitro)

		PDK3	PDHA1
Gene Name		pyruvate dehydrogenase kinase, isozyme 3	pyruvate dehydrogenase (lipoamide) alpha 1
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Nucleus Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding	Pyruvate Dehydrogenase Activity Pyruvate Dehydrogenase (acetyl-transferring) Activity
	Biological Process	Glucose Metabolic Process Pyruvate Metabolic Process Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Glucose Metabolic Process Peptidyl-serine Phosphorylation Peroxisome Proliferator Activated Receptor Signaling Pathway Cellular Metabolic Process Small Molecule Metabolic Process Cellular Response To Glucose Stimulus Cellular Response To Fatty Acid Hypoxia-inducible Factor-1alpha Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process	Glucose Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Pyruvate Metabolic Process Glycolytic Process Tricarboxylic Acid Cycle Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Cellular Metabolic Process Small Molecule Metabolic Process
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Signaling by Retinoic Acid Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport	Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Signaling by Retinoic Acid Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport
Drugs			NADH
Diseases
GWAS
Protein-Protein Interactions		4 interactors: APP DLAT EGFR PDHA1	8 interactors: DLAT EIF6 PDHB PDK1 PDK2 PDK3 PDK4 PDP1
Entrez ID		5165	5160
HPRD ID		03956	02420
Ensembl ID		ENSG00000067992	ENSG00000131828
Uniprot IDs		Q15120	P08559
PDB IDs		1Y8N 1Y8O 1Y8P 2PNR 2Q8I	1NI4 2OZL 3EXE 3EXF 3EXG 3EXH 3EXI
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Ketone Metabolic Process Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Acyl-CoA Biosynthetic Process Regulation Of Phosphorus Metabolic Process Tricarboxylic Acid Cycle Citrate Metabolic Process Tricarboxylic Acid Metabolic Process Aerobic Respiration Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Fatty Acid Metabolic Process Pyruvate Metabolic Process Alkanesulfonate Metabolic Process Glucose Metabolic Process Cellular Respiration Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Synaptic Growth At Neuromuscular Junction Astrocyte Activation Hexose Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Collateral Sprouting In Absence Of Injury Activation Of Phospholipase A2 Activity Acetyl-CoA Biosynthetic Process From Pyruvate Monosaccharide Metabolic Process Learning Or Memory Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Phospholipase A2 Activity Positive Regulation Of Cell Cycle Cognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Response To Cobalamin Response To UV-A Regulation Of Lipid Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Axon Choice Point Recognition Response To Hydroxyisoflavone Response To Light Stimulus Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Superoxide Anion Generation Acetyl-CoA Biosynthetic Process Sulfur Compound Metabolic Process Neuron Remodeling Axon Guidance Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Catenin Import Into Nucleus Regulation Of Mitotic Cell Cycle Generation Of Precursor Metabolites And Energy Response To Oxidative Stress Regulation Of Phospholipase A2 Activity	Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Acyl-CoA Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Pyruvate Metabolic Process Regulation Of Lipid Metabolic Process Glucose Metabolic Process Hexose Metabolic Process Regulation Of Cellular Ketone Metabolic Process Monosaccharide Metabolic Process Monocarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Regulation Of Glucose Metabolic Process Regulation Of Phosphorus Metabolic Process Hypoxia-inducible Factor-1alpha Signaling Pathway Regulation Of Carbohydrate Metabolic Process Carbohydrate Metabolic Process Small Molecule Metabolic Process Insulin Receptor Signaling Pathway Glucose Homeostasis Cellular Response To Insulin Stimulus Tricarboxylic Acid Cycle Response To Insulin Cellular Response To Fatty Acid Citrate Metabolic Process Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Tricarboxylic Acid Metabolic Process Aerobic Respiration Regulation Of PH Response To Fatty Acid Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Protein Phosphorylation Cellular Response To Oxygen Levels Acetyl-CoA Biosynthetic Process From Pyruvate Cellular Response To Hormone Stimulus Cellular Protein Metabolic Process Cellular Response To Stress Phosphate-containing Compound Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Metabolic Process Cellular Respiration Cellular Response To Acid Chemical Cellular Response To Nutrient Levels Intrinsic Apoptotic Signaling Pathway Cellular Protein Modification Process
Tagcloud ?			coffin decalvans dxs1052 dxs1053 dxs1195 dxs1229 dxs197 dxs207 dxs274 dxs365 dxs414 dxs418 dxs443 dxs451 dxs7101 dxs7161 dxs7592 dxs7593 dxs987 dxs989 dxs999 follicularis kfsd kqst80h1 lowry retinoschisis rp15 spinulosa xlh
Tagcloud (Difference) ?			coffin decalvans dxs1052 dxs1053 dxs1195 dxs1229 dxs197 dxs207 dxs274 dxs365 dxs414 dxs418 dxs443 dxs451 dxs7101 dxs7161 dxs7592 dxs7593 dxs987 dxs989 dxs999 follicularis kfsd kqst80h1 lowry retinoschisis rp15 spinulosa xlh
Tagcloud (Intersection) ?