PDK3

Gene Name		pyruvate dehydrogenase kinase, isozyme 3
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Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding
	Biological Process	Glucose Metabolic Process Pyruvate Metabolic Process Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Glucose Metabolic Process Peptidyl-serine Phosphorylation Peroxisome Proliferator Activated Receptor Signaling Pathway Cellular Metabolic Process Small Molecule Metabolic Process Cellular Response To Glucose Stimulus Cellular Response To Fatty Acid Hypoxia-inducible Factor-1alpha Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Signaling by Retinoic Acid Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport
Drugs
Diseases
GWAS
Protein-protein Interactions		4 interactors: APP DLAT EGFR PDHA1
Entrez ID		5165
HPRD ID		03956
Ensembl ID		ENSG00000067992
Uniprot IDs		Q15120
PDB IDs		1Y8N 1Y8O 1Y8P 2PNR 2Q8I
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Ketone Metabolic Process Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Acyl-CoA Biosynthetic Process Regulation Of Phosphorus Metabolic Process Tricarboxylic Acid Cycle Citrate Metabolic Process Tricarboxylic Acid Metabolic Process Aerobic Respiration Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Fatty Acid Metabolic Process Pyruvate Metabolic Process Alkanesulfonate Metabolic Process Glucose Metabolic Process Cellular Respiration Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Synaptic Growth At Neuromuscular Junction Astrocyte Activation Hexose Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Collateral Sprouting In Absence Of Injury Activation Of Phospholipase A2 Activity Acetyl-CoA Biosynthetic Process From Pyruvate Monosaccharide Metabolic Process Learning Or Memory Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Phospholipase A2 Activity Positive Regulation Of Cell Cycle Cognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Response To Cobalamin Response To UV-A Regulation Of Lipid Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Axon Choice Point Recognition Response To Hydroxyisoflavone Response To Light Stimulus Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Superoxide Anion Generation Acetyl-CoA Biosynthetic Process Sulfur Compound Metabolic Process Neuron Remodeling Axon Guidance Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Catenin Import Into Nucleus Regulation Of Mitotic Cell Cycle Generation Of Precursor Metabolites And Energy Response To Oxidative Stress Regulation Of Phospholipase A2 Activity
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