PDK3

Description		pyruvate dehydrogenase kinase 3
Image
GO Annotations	Cellular Component	Nucleolus Mitochondrion Mitochondrial Matrix
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Glucose Metabolic Process Peptidyl-serine Phosphorylation Cellular Response To Stress Peroxisome Proliferator Activated Receptor Signaling Pathway Cellular Response To Fatty Acid Hypoxia-inducible Factor-1alpha Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid
Drugs		Radicicol Dihydrolipoic Acid
Diseases
GWAS		Malaria ( 31844061)
Interacting Genes		4 interacting genes: APP DLAT EGFR PDHA1
Entrez ID		5165
HPRD ID		03956
Ensembl ID		ENSG00000067992
Uniprot IDs		Q15120
PDB IDs		1Y8N 1Y8O 1Y8P 2PNR 2Q8I
Enriched GO Terms of Interacting Partners?		Pyruvate Decarboxylation To Acetyl-CoA Pyruvate Dehydrogenase Complex Acetyl-CoA Biosynthetic Process Acetyl-CoA Metabolic Process Tricarboxylic Acid Cycle Pyruvate Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Sulfur Compound Biosynthetic Process Acyl-CoA Metabolic Process Multivesicular Body, Internal Vesicle Lumen Glucose Metabolic Process Positive Regulation Of Mitotic Cell Cycle Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of ERK1 And ERK2 Cascade Dihydrolipoyllysine-residue Acetyltransferase Activity Monosaccharide Metabolic Process Amide Biosynthetic Process Hexose Metabolic Process Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Shc-EGFR Complex Pyruvate Dehydrogenase (acetyl-transferring) Activity Receptor Complex Membrane Raft Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Early Endosome Membrane Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Epidermal Growth Factor Binding Intermediate-density Lipoprotein Particle
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