MRPL48 and EXOSC2

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
BioGRID (two hybrid)

		MRPL48	EXOSC2
Gene Name		mitochondrial ribosomal protein L48	exosome component 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrial Inner Membrane Mitochondrial Ribosome	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleolus Cytoplasm Cytosol
	Molecular Function	Protein Binding	3'-5'-exoribonuclease Activity Exoribonuclease Activity Protein Binding 7S RNA Binding
	Biological Process	Organelle Organization Mitochondrial Translation Mitochondrial Translational Initiation Mitochondrial Translational Elongation Mitochondrial Translational Termination	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Gene Expression Positive Regulation Of Cell Growth Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription Polyadenylation-dependent SnoRNA 3'-end Processing
Pathways		Mitochondrial translation Organelle biogenesis and maintenance Mitochondrial translation elongation Mitochondrial translation initiation Mitochondrial translation termination	Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		4 interactors: APP EXOSC2 LSM8 OXA1L	16 interactors: DIS3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 GALNT13 KHSRP MPP6 MRPL48 RNF8 SKIV2L2 ST6GALNAC1 UPF1 ZNF408
Entrez ID		51642	23404
HPRD ID		14767	03758
Ensembl ID			ENSG00000130713
Uniprot IDs		B4DN34 Q96GC5	B3KQW2 Q13868
PDB IDs			2NN6
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process RNA Processing RNA 3'-end Processing Nuclear Polyadenylation-dependent TRNA Catabolic Process Synaptic Growth At Neuromuscular Junction Mitochondrial Proton-transporting ATP Synthase Complex Assembly Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing Collateral Sprouting In Absence Of Injury TRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Proton-transporting ATP Synthase Complex Assembly Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Collateral Sprouting Axon Midline Choice Point Recognition SnoRNA Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Nuclear MRNA Surveillance RRNA 3'-end Processing Negative Regulation Of ATPase Activity RNA Surveillance Neuron Remodeling Negative Regulation Of Hydrolase Activity Intracellular MRNA Localization MRNA Processing RRNA Catabolic Process Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Mitochondrial Respiratory Chain Complex I Assembly Mitochondrial Respiratory Chain Complex I Biogenesis Protein Insertion Into Membrane Maturation Of 5.8S RRNA Cellular Copper Ion Homeostasis Copper Ion Homeostasis Suckling Behavior Regulation Of Growth Cellular Localization Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Negative Regulation Of Oxidoreductase Activity Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Mitochondrial Respiratory Chain Complex Assembly Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity SnRNA Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RRNA Processing RRNA Metabolic Process MRNA Catabolic Process RNA Catabolic Process Ribosome Biogenesis Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process Ribonucleoprotein Complex Biogenesis MRNA Metabolic Process Aromatic Compound Catabolic Process NcRNA Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Macromolecule Catabolic Process RNA Phosphodiester Bond Hydrolysis DNA Deamination Catabolic Process RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Maturation Of 5.8S RRNA Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Nitrogen Compound Metabolic Process Nuclear MRNA Surveillance RNA Surveillance Histone MRNA Catabolic Process DNA Modification RRNA Catabolic Process Histone MRNA Metabolic Process Isotype Switching Metabolic Process Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response B Cell Activation Involved In Immune Response DNA Metabolic Process Immunoglobulin Production Histone H2A K63-linked Ubiquitination Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Positive Regulation Of Cell Growth MRNA Transport RNA Transport RNA Localization Leukocyte Activation Involved In Immune Response
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