AZIN1 and FANCA

Number of citations: 0 (PubMedID 14499622)
Data Source: BioGRID (two hybrid)

		AZIN1	FANCA
Name		antizyme inhibitor 1	FA complementation group A
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Fanconi Anaemia Nuclear Complex
	Molecular Function	Catalytic Activity Ornithine Decarboxylase Activity Protein Binding Ornithine Decarboxylase Activator Activity	Protein Binding
	Biological Process	Polyamine Biosynthetic Process Putrescine Biosynthetic Process From Arginine, Via Ornithine Negative Regulation Of Protein Catabolic Process Positive Regulation Of Polyamine Transmembrane Transport	DNA Repair DNA Damage Response Male Meiotic Nuclear Division Male Gonad Development Female Gonad Development Interstrand Cross-link Repair Regulation Of Regulatory T Cell Differentiation Regulation Of Inflammatory Response Protein-containing Complex Assembly Regulation Of Germ Cell Proliferation Regulation Of CD40 Signaling Pathway
Pathways		Regulation of ornithine decarboxylase (ODC)	Fanconi Anemia Pathway PKR-mediated signaling
Diseases		None	Fanconi anemia
GWAS		Airway imaging phenotypes ( 26030696 ) Apolipoprotein A1 levels ( 32203549 ) Granulocyte count ( 27863252 ) HDL cholesterol levels ( 32203549 ) Immature fraction of reticulocytes ( 32888494 ) Mean platelet volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Neutrophil count ( 27863252 ) PR interval ( 32439900 ) QT interval ( 24952745 ) Serum alkaline phosphatase levels ( 33547301 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) TPE interval (resting) ( 32386560 ) Waist circumference adjusted for body mass index ( 28552196 ) White blood cell count ( 32888494 )	Brain morphology (MOSTest) ( 32665545 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Hair morphology traits ( 30166351 ) Hemoglobin levels ( 32327693 ) Homocysteine levels ( 23824729 ) Intraocular pressure ( 29617998 29785010 30054594 31959993 ) Low tan response ( 29739929 ) Monocyte count ( 32888494 ) Monocyte percentage of white cells ( 32888494 ) Red vs. brown/black hair color ( 30531825 ) Rosacea symptom severity ( 29771307 ) Skin pigmentation traits ( 30166351 )
Interacting Genes		7 interacting genes: ABCC2 ADSS1 BMAL1 CDKN2A FANCA FANCC KHDRBS1	47 interacting genes: AKT1 ALDOA ATP5F1B ATR AURKA AZIN1 BRCA1 CAPN1 CCT3 CD79A CDK1 CENPE DAXX DDX39B DNAJB1 DUS4L ENO1 FANCC FANCE FANCF FANCG GNB2 HES1 HPRT1 IFIT3 IKBKB KRT1 LIPG MKNK1 MX1 NAMPT NUB1 PRKAA1 PRPF31 PSMA5 RPL18 SGK1 SMARCA4 SMARCC1 SMARCD3 SNX5 SPTAN1 TAF10 TCERG1 TCP1 TPT1 ZNF24
Entrez ID		51582	2175
HPRD ID		07443	06186
Ensembl ID		ENSG00000155096	ENSG00000187741
Uniprot IDs		A0A804HLH4 B3KTF6 O14977	O15360 Q0VAP4
PDB IDs		4ZGZ	7KZP 7KZQ 7KZR 7KZS 7KZT 7KZV
GO Terms Enriched among Interactors		Fanconi Anaemia Nuclear Complex Cellular Senescence Ligase Inhibitor Activity Bilirubin Transmembrane Transporter Activity Bilirubin Transport Interstrand Cross-link Repair Grb2-Sos Complex	Positive Regulation Of DNA Metabolic Process Nucleus Protein-containing Complex Organization Interstrand Cross-link Repair Fanconi Anaemia Nuclear Complex Regulation Of Mitotic Cell Cycle Phase Transition Cytosol Regulation Of Chromosome Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA Metabolic Process Cytoplasm Regulation Of Mitotic Cell Cycle Regulation Of Cellular Response To Stress Nucleoplasm Regulation Of Cell Cycle Phase Transition Protein-containing Complex Assembly Protein Serine Kinase Activity Positive Regulation Of Macromolecule Metabolic Process DNA Strand Resection Involved In Replication Fork Processing NpBAF Complex Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Chromatin Remodeling Identical Protein Binding Regulation Of G2/M Transition Of Mitotic Cell Cycle NBAF Complex Regulation Of Sister Chromatid Segregation Regulation Of Organelle Organization Protein Serine/threonine Kinase Activity ATP Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle G2/M Phase Transition RNA Polymerase Binding Response To Tumor Necrosis Factor Regulation Of Signal Transduction By P53 Class Mediator Nucleosome Disassembly Positive Regulation Of Mitotic Cell Cycle Protein-DNA Complex Disassembly Regulation Of Chromosome Segregation Positive Regulation Of Telomere Maintenance Via Telomerase Nucleotide Binding Positive Regulation Of Biosynthetic Process Regulation Of DNA Repair Protein K6-linked Ubiquitination Regulation Of Cellular Component Organization Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Phosphate-containing Compound Metabolic Process Protein Serine/threonine/tyrosine Kinase Activity Protein Kinase Activity Regulation Of Protein Localization To Nucleus