AZIN1 and ABCC2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		AZIN1	ABCC2
Description		antizyme inhibitor 1	ATP binding cassette subfamily C member 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Intercellular Canaliculus
	Molecular Function	Catalytic Activity Ornithine Decarboxylase Activity Protein Binding Ornithine Decarboxylase Activator Activity	Nucleotide Binding Protein Binding ATP Binding Organic Anion Transmembrane Transporter Activity ABC-type Xenobiotic Transporter Activity Bilirubin Transmembrane Transporter Activity ABC-type Glutathione S-conjugate Transporter Activity ATP Hydrolysis Activity Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity ABC-type Transporter Activity
	Biological Process	Polyamine Biosynthetic Process Putrescine Biosynthetic Process From Arginine, Via Ornithine Negative Regulation Of Protein Catabolic Process Positive Regulation Of Polyamine Transmembrane Transport	Xenobiotic Metabolic Process Xenobiotic Transmembrane Transport Lipid Transport Negative Regulation Of Gene Expression Bile Acid And Bile Salt Transport Bilirubin Transport Heme Catabolic Process Xenobiotic Export From Cell Carboxylic Acid Transport Transmembrane Transport Transepithelial Transport Leukotriene Transport Monoatomic Anion Transmembrane Transport Transport Across Blood-brain Barrier Xenobiotic Transport Across Blood-brain Barrier
Pathways		Regulation of ornithine decarboxylase (ODC)	Heme degradation ABC-family proteins mediated transport Defective ABCC2 causes DJS Aspirin ADME Paracetamol ADME Atorvastatin ADME
Drugs			ATP Sulfinpyrazone Azvudine
Diseases			Hyperbilirubinemia; Crigler-Najjar syndrome, type I (CN1); Crigler-Najjar syndrome, type II (CN2); Gilbert Syndrome; Dubin-Johnson syndrome (DJS)
GWAS		Airway imaging phenotypes ( 26030696) Apolipoprotein A1 levels ( 32203549) Granulocyte count ( 27863252) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Neutrophil count ( 27863252) PR interval ( 32439900) QT interval ( 24952745) Serum alkaline phosphatase levels ( 33547301) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) TPE interval (resting) ( 32386560) Waist circumference adjusted for body mass index ( 28552196) White blood cell count ( 32888494)	Carboplatin disposition in epthelial ovarian cancer ( 29367611) Colorectal cancer ( 24737748 26151821) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Serum metabolite levels ( 33031748) Stent thrombosis in response to clopidogrel treatment ( 32472697)
Interacting Genes		7 interacting genes: ABCC2 ADSS1 BMAL1 CDKN2A FANCA FANCC KHDRBS1	12 interacting genes: AZIN1 CANX HSPA4 MCPH1 NFKB1 NHERF1 NHERF4 PDZK1 RDX SHANK3 TUBB3 UBQLN1
Entrez ID		51582	1244
HPRD ID		07443	03065
Ensembl ID		ENSG00000155096	ENSG00000023839
Uniprot IDs		A0A804HLH4 B3KTF6 O14977	Q92887
PDB IDs		4ZGZ	8IZQ 8IZR 8JX7 8JXQ 8JXU 8JY4 8JY5 9BR2 9BUK 9C12 9C2I
Enriched GO Terms of Interacting Partners?		Fanconi Anaemia Nuclear Complex Cellular Senescence Ligase Inhibitor Activity Bilirubin Transmembrane Transporter Activity Bilirubin Transport Interstrand Cross-link Repair Grb2-Sos Complex	Protein-membrane Adaptor Activity Protein Localization To Membrane Intracellular Protein Localization Protein Localization To Plasma Membrane Microvillus Assembly Protein Localization To Cell Periphery Microvillus Organization Localization Within Membrane Filopodium Apical Part Of Cell Cell Periphery Apical Plasma Membrane Microvillus Membrane Regulation Of Transport Stereocilium Brush Border Membrane Regulation Of Cellular Component Size Renal Phosphate Ion Absorption Negative Regulation Of Store-operated Calcium Channel Activity Guanylate Cyclase Inhibitor Activity Brush Border Extracellular Exosome NF-kappaB P50/p65 Complex PDZ Domain Binding Microvillus Type 2 Metabotropic Glutamate Receptor Binding Regulation Of Cell Size Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Netrin Receptor Binding Ornithine Decarboxylase Activator Activity Positive Regulation Of Polyamine Transmembrane Transport Guanylate Kinase-associated Protein Clustering ERAD Pathway Positive Regulation Of Hyaluronan Biosynthetic Process I-kappaB/NF-kappaB Complex Regulation Of Protein Catabolic Process Regulation Of Postsynaptic Neurotransmitter Receptor Diffusion Trapping Type 3 Metabotropic Glutamate Receptor Binding Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Ornithine Decarboxylase Activity Putrescine Biosynthetic Process From Arginine, Via Ornithine Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Negative Regulation Of Vitamin D Biosynthetic Process Signaling Receptor Binding Cellular Localization Regulation Of Monoatomic Ion Transport Scavenger Receptor Binding Stereocilium Base
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