GDE1 and RGS16

Number of citations of the paper that reports this interaction (PubMedID 10760272)
39

Data Source:
HPRD (two hybrid, in vitro)

		GDE1	RGS16
Description		glycerophosphodiester phosphodiesterase 1	regulator of G protein signaling 16
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle	Cytoplasm Plasma Membrane Membrane
	Molecular Function	Phosphatidylcholine Lysophospholipase Activity Protein Binding Phosphoric Diester Hydrolase Activity Glycerophosphodiester Phosphodiesterase Activity Hydrolase Activity Metal Ion Binding Glycerophosphoinositol Glycerophosphodiesterase Activity	GTPase Activity GTPase Activator Activity Protein Binding Calmodulin Binding
	Biological Process	Ethanolamine Metabolic Process Lipid Metabolic Process Phospholipid Metabolic Process Glycerophospholipid Catabolic Process N-acylethanolamine Metabolic Process	G Protein-coupled Receptor Signaling Pathway Visual Perception Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of GTPase Activity
Pathways		Glycerophospholipid catabolism	G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events
Drugs
Diseases
GWAS			Chronotype ( 26955885 27494321 30696823) Morning person ( 30696823) Morning vs. evening chronotype ( 26835600 26955885 27494321) Sleep traits (multi-trait analysis) ( 27992416)
Interacting Genes		7 interacting genes: ADRA1A CLGN RGS1 RGS16 RGS19 RGS2 SLC10A1	14 interacting genes: CREB3L2 CSK EGFR GDE1 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAT1 LYN SRC ST14
Entrez ID		51573	6004
HPRD ID		12070	03945
Ensembl ID		ENSG00000006007	ENSG00000143333
Uniprot IDs		Q9NZC3	O15492
PDB IDs			2BT2 2IK8
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cardiac Muscle Contraction GTPase Activity Positive Regulation Of Striated Muscle Contraction G-protein Alpha-subunit Binding Calmodulin Binding Positive Regulation Of Heart Contraction GTPase Activator Activity Positive Regulation Of Muscle Contraction Regulation Of Smooth Muscle Contraction Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Regulation Of Cardiac Muscle Hypertrophy Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Regulation Of Cardiac Muscle Contraction Positive Regulation Of GTPase Activity Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Phospholipase C-activating Adrenergic Receptor Signaling Pathway Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Striated Muscle Contraction Cytoplasmic Side Of Plasma Membrane Negative Regulation Of Glycine Import Across Plasma Membrane Positive Regulation Of Hydrolase Activity Response To Ethanol Pilomotor Reflex Alpha1-adrenergic Receptor Activity Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Negative Regulation Of Signal Transduction Regulation Of GTPase Activity Membrane Leukotriene Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase Inhibitor Activity Plasma Membrane Regulation Of Muscle Contraction Neuron-glial Cell Signaling Bile Acid:sodium Symporter Activity Regulation Of The Force Of Heart Contraction By Chemical Signal Relaxation Of Vascular Associated Smooth Muscle Regulation Of Signal Transduction Regulation Of Heart Contraction Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Relaxation Of Smooth Muscle Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Action Potential Adrenergic Receptor Activity Bile Acid Transmembrane Transporter Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway	Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex G Protein-coupled Receptor Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway GTPase Activity Nucleotide Binding GTP Binding G Protein Activity Plasma Membrane Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Regulation Of ERK1 And ERK2 Cascade Membrane Protein Tyrosine Kinase Activity Adenylate Cyclase Regulator Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Protein Localization To Cell Periphery T Cell Costimulation Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Catalytic Activity Signaling Receptor Activator Activity Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity GDP Binding Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Protein Localization To Cell Periphery Signal Transduction Regulation Of Cell Communication Regulation Of Protein Localization Regulation Of Signaling Phototransduction, Visible Light Regulation Of Catalytic Activity Extracellular Exosome Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Tyrosine Kinase Activator Activity Response To Peptide Hormone Response To Hormone Ciliary Basal Body Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Protein Transport Regulation Of MAPK Cascade G Protein-coupled Acetylcholine Receptor Signaling Pathway Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis ERBB2 Signaling Pathway
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