GDE1 and RGS19

Number of citations of the paper that reports this interaction (PMID 10760272)
14

Data Source:
HPRD (two hybrid)

		GDE1	RGS19
Gene Name		glycerophosphodiester phosphodiesterase 1	regulator of G-protein signaling 19
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Integral Component Of Membrane	Cytoplasm Golgi Apparatus Heterotrimeric G-protein Complex Plasma Membrane Brush Border Membrane Clathrin-coated Vesicle
	Molecular Function	Glycerophosphodiester Phosphodiesterase Activity Metal Ion Binding Glycerophosphoinositol Glycerophosphodiesterase Activity	G-protein Alpha-subunit Binding GTPase Activator Activity Protein Binding
	Biological Process	Glycerol Metabolic Process Lipid Metabolic Process	Autophagy G-protein Coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity
Pathways			G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK G alpha (z) signalling events G alpha (i) signalling events
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: CLGN RGS1 RGS16 RGS19 RGS2	15 interactors: CSNK2A1 CSNK2A2 GDE1 GIPC1 GNAI1 GNAI2 GNAI3 GNAO1 GNAZ MAPK1 MAPK6 OPRL1 OSTM1 PRKCA TGFBR1
Entrez ID		51573	10287
HPRD ID		12070	05461
Ensembl ID		ENSG00000006007	ENSG00000171700
Uniprot IDs		Q9NZC3	B4DP94 P49795
PDB IDs			1CMZ
Enriched GO Terms of Interacting Partners?		Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Positive Regulation Of Hydrolase Activity Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Regulation Of Signal Transduction Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Signaling Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Phospholipase Activity Relaxation Of Vascular Smooth Muscle Positive Regulation Of Metabolic Process Negative Regulation Of Cardiac Muscle Hypertrophy Relaxation Of Smooth Muscle Negative Regulation Of Muscle Hypertrophy Positive Regulation Of Striated Muscle Contraction Positive Regulation Of Microtubule Polymerization Relaxation Of Cardiac Muscle Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Lipase Activity Negative Regulation Of Muscle Contraction Regulation Of CAMP-mediated Signaling Relaxation Of Muscle Positive Regulation Of Heart Contraction Regulation Of Microtubule Polymerization Regulation Of Cardiac Muscle Hypertrophy Vasodilation Binding Of Sperm To Zona Pellucida Brown Fat Cell Differentiation Sexual Reproduction Sperm-egg Recognition Regulation Of Smooth Muscle Contraction Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Cell-cell Recognition Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Cardiac Muscle Contraction Reproduction Negative Regulation Of MAP Kinase Activity Regulation Of Phospholipase Activity Regulation Of Striated Muscle Contraction	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Cell Cycle Synaptic Transmission Platelet Activation G-protein Coupled Receptor Signaling Pathway Signal Transduction Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Signaling Cell-cell Signaling Cell Communication Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of CAMP Metabolic Process Wound Healing Negative Regulation Of Nucleotide Metabolic Process Cell Activation Response To Wounding Peptidyl-threonine Phosphorylation Cellular Response To Stimulus Blood Coagulation Hemostasis Regulation Of Adenylate Cyclase Activity Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Activation Of MAPKK Activity Regulation Of Cyclase Activity Negative Regulation Of Cellular Protein Catabolic Process Regulation Of Body Fluid Levels Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Response To Stimulus Negative Regulation Of Protein Catabolic Process Peptidyl-serine Phosphorylation Locomotion Positive Regulation Of Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Proliferation Positive Regulation Of MAPK Cascade Movement Of Cell Or Subcellular Component Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Regulation Of Proteasomal Protein Catabolic Process Apoptotic Process Programmed Cell Death Mitotic Spindle Checkpoint
Tagcloud ?		acuity architecture cerevisiae cohorts cortex disequilibrium glycerophosphocholine gpcpd1 heritable homolog imputed linkage metaanalysis occipital perception phosphodiesterase proportional remainder replicated rs238295 rs6116869 saccharomyces snp snps threefold underlie utr varies visual	accelerating adenylate c6 cyclase dampen depressant galphai galphai2 gap gaps go gpcr gpcrs gtpase hairpin ht1a implicating insensitive medications mood neuroblastoma postsynaptic prefrontal raphe shrna sy5y synergy viable
Tagcloud (Difference) ?		acuity architecture cerevisiae cohorts cortex disequilibrium glycerophosphocholine gpcpd1 heritable homolog imputed linkage metaanalysis occipital perception phosphodiesterase proportional remainder replicated rs238295 rs6116869 saccharomyces snp snps threefold underlie utr varies visual	accelerating adenylate c6 cyclase dampen depressant galphai galphai2 gap gaps go gpcr gpcrs gtpase hairpin ht1a implicating insensitive medications mood neuroblastoma postsynaptic prefrontal raphe shrna sy5y synergy viable
Tagcloud (Intersection) ?