GDE1 and RGS1

Number of citations of the paper that reports this interaction (PubMedID 10760272)
39

Data Source:
HPRD (two hybrid)

		GDE1	RGS1
Description		glycerophosphodiester phosphodiesterase 1	regulator of G protein signaling 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle	Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane
	Molecular Function	Phosphatidylcholine Lysophospholipase Activity Protein Binding Phosphoric Diester Hydrolase Activity Glycerophosphodiester Phosphodiesterase Activity Hydrolase Activity Metal Ion Binding Glycerophosphoinositol Glycerophosphodiesterase Activity	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Calmodulin Binding
	Biological Process	Ethanolamine Metabolic Process Lipid Metabolic Process Phospholipid Metabolic Process Glycerophospholipid Catabolic Process N-acylethanolamine Metabolic Process	Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Response To Bacterium Negative Regulation Of Signal Transduction Positive Regulation Of GTPase Activity Leukotriene Signaling Pathway
Pathways		Glycerophospholipid catabolism	G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events
Drugs
Diseases
GWAS			Celiac disease ( 18311140 20190752 22057235 30572963) Multiple sclerosis ( 21833088 24076602 27386562) Systemic lupus erythematosus ( 28714469 33536424) Systemic vasculitis ( 29374629) Type 1 diabetes ( 34127860)
Interacting Genes		7 interacting genes: ADRA1A CLGN RGS1 RGS16 RGS19 RGS2 SLC10A1	9 interacting genes: APP FBXO7 FUNDC2 GDE1 GIPC1 GNAO1 MAP3K12 TSC22D1 UTP14A
Entrez ID		51573	5996
HPRD ID		12070	15968
Ensembl ID		ENSG00000006007	ENSG00000090104
Uniprot IDs		Q9NZC3	Q08116
PDB IDs			2BV1 2GTP
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cardiac Muscle Contraction GTPase Activity Positive Regulation Of Striated Muscle Contraction G-protein Alpha-subunit Binding Calmodulin Binding Positive Regulation Of Heart Contraction GTPase Activator Activity Positive Regulation Of Muscle Contraction Regulation Of Smooth Muscle Contraction Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Regulation Of Cardiac Muscle Hypertrophy Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Regulation Of Cardiac Muscle Contraction Positive Regulation Of GTPase Activity Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Phospholipase C-activating Adrenergic Receptor Signaling Pathway Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Striated Muscle Contraction Cytoplasmic Side Of Plasma Membrane Negative Regulation Of Glycine Import Across Plasma Membrane Positive Regulation Of Hydrolase Activity Response To Ethanol Pilomotor Reflex Alpha1-adrenergic Receptor Activity Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Negative Regulation Of Signal Transduction Regulation Of GTPase Activity Membrane Leukotriene Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase Inhibitor Activity Plasma Membrane Regulation Of Muscle Contraction Neuron-glial Cell Signaling Bile Acid:sodium Symporter Activity Regulation Of The Force Of Heart Contraction By Chemical Signal Relaxation Of Vascular Associated Smooth Muscle Regulation Of Signal Transduction Regulation Of Heart Contraction Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Relaxation Of Smooth Muscle Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Action Potential Adrenergic Receptor Activity Bile Acid Transmembrane Transporter Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway	Response To Norepinephrine Cellular Response To Norepinephrine Stimulus Cellular Response To Catecholamine Stimulus Response To Catecholamine Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Amyloid-beta Complex Dendritic Shaft Growth Cone Lamellipodium Regulation Of Neuron Apoptotic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Skeletal Muscle Contraction By Modulation Of Calcium Ion Sensitivity Of Myofibril Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Ethanolamine Metabolic Process Glycerophosphoinositol Glycerophosphodiesterase Activity G Protein-coupled Receptor Signaling Pathway Autophagy Of Mitochondrion Regulation Of Cell Communication Regulation Of Signaling Acetylcholine Receptor Activator Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Cell Body Lipoprotein Particle Positive Regulation Of Signal Transduction Positive Regulation Of Protein Import Defense Response To Gram-negative Bacterium Mu-type Opioid Receptor Binding PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Protein Transport Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization G Protein-coupled Serotonin Receptor Binding Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Lewy Body Core Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Corticotropin-releasing Hormone Receptor 1 Binding
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