CYRIB and NIF3L1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		CYRIB	NIF3L1
Description		CYFIP related Rac1 interactor B	NGG1 interacting factor 3 like 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Mitochondrion Cilium Membrane Platelet Alpha Granule Lumen Extracellular Exosome	Nucleus Cytoplasm Mitochondrion
	Molecular Function	Protein Binding MHC Class Ib Protein Binding, Via Antigen Binding Groove Small GTPase Binding	Protein Binding Identical Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of Cell Migration Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Type II Interferon Production Positive Regulation Of T Cell Activation Regulation Of Chemotaxis Negative Regulation Of Small GTPase Mediated Signal Transduction Cellular Response To Molecule Of Bacterial Origin Regulation Of Mitochondrial Fission Regulation Of Establishment Of Cell Polarity Positive Regulation Of Memory T Cell Activation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Neuron Differentiation Positive Regulation Of DNA-templated Transcription
Pathways		Platelet degranulation
Drugs
Diseases
GWAS			Triptolide cytotoxicity ( 26121980)
Interacting Genes		3 interacting genes: HIP1 MAPK6 NIF3L1	93 interacting genes: ALKBH4 AP5B1 APIP ARPIN BDKRB2 BEND7 C14orf119 CASP7 CCDC102B CCDC85B CDKN2B CDKN2C CDKN2D COIL COPS2 CUTC CYRIB DCDC2 DCTD DCTPP1 DHPS DMC1 DMRTB1 DTX2 DUSP23 DUSP29 DYNLT3 EIF4A3 EIF5A2 ENOX1 EPHB6 FLAD1 FXR2 GNMT GRB2 IP6K3 KCNIP1 KCTD17 KCTD7 KCTD9 KRT15 KXD1 LAMTOR3 LMO2 LMO3 MAGEA11 MAPRE2 MLXIPL NATD1 NEK6 NGB NME1 NME7 NOL3 NUDT14 NUDT21 ORC5 PAFAH1B3 PAICS PCBD1 PNMA1 POLR1C PPIH PRTFDC1 PTPA RABAC1 RAD54B RPIA S100A1 SAT1 SEPTIN1 SNF8 SPG21 SSX2IP STAT3 STK16 SULT1A2 SULT1A3 SULT2A1 SYT17 TCL1A THOC7 TIFA TRAF2 TRIM21 TRIM27 TRIP13 TSC22D4 TXN VIM YES1 YWHAQ ZBED1
Entrez ID		51571	60491
HPRD ID		13313	10424
Ensembl ID		ENSG00000153310	ENSG00000196290
Uniprot IDs		A0A8V8TMP7 Q9NUQ9	Q9GZT8
PDB IDs		7AJK
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Glutamate Receptor Binding Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Protein Heterodimerization Activity Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Clathrin Light Chain Binding Septin Cytoskeleton AP-2 Adaptor Complex Binding Neurotransmitter Receptor Transport MAP Kinase Activity	Identical Protein Binding Cytoplasm Protein Binding Cytosol Protein Complex Oligomerization Nucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Ethanol Catabolic Process Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Ethanol Metabolic Process Nucleoside Phosphate Metabolic Process Phosphate-containing Compound Metabolic Process Sulfation Pyrimidine Nucleotide Metabolic Process Polyamine Catabolic Process Nucleus Ribose Phosphate Metabolic Process Reciprocal Meiotic Recombination
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