PDGFRL and PCM1

		PDGFRL	PCM1
Description		platelet derived growth factor receptor like	pericentriolar material 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Pericentriolar Material Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cilium Microtubule Cytoskeleton Membrane Nuclear Membrane Protein-containing Complex Centriolar Satellite Ciliary Transition Zone Ciliary Basal Body Cell Projection Apical Part Of Cell Non-motile Cilium
	Molecular Function	Platelet Activating Factor Receptor Activity Platelet-derived Growth Factor Receptor Activity Platelet-derived Growth Factor Beta-receptor Activity	Protein Binding Identical Protein Binding Molecular Adaptor Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway Platelet-derived Growth Factor Receptor-beta Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus Platelet-derived Growth Factor Receptor Signaling Pathway	Neuron Migration Centrosome Cycle Interkinetic Nuclear Migration Cell Projection Organization Cytoplasmic Microtubule Organization Protein Localization To Organelle Microtubule Anchoring Microtubule Anchoring At Centrosome Social Behavior Intraciliary Transport Involved In Cilium Assembly Negative Regulation Of Neurogenesis Cilium Assembly Regulation Of Protein Complex Stability Protein Localization To Centrosome Positive Regulation Of Intracellular Protein Transport Neuronal Stem Cell Population Maintenance Protein-containing Complex Localization To Centriolar Satellite Non-motile Cilium Assembly
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Hippocampal volume in normal cognition ( 29274321) Placental abruption ( 29884306) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Plasma parathyroid hormone levels ( 30134803) Spatial memory ( 31596458) Sphingomyelin 24:0 levels ( 31560688)	Atrial fibrillation ( 28416818) Economic and political preferences ( 22566634) Heel bone mineral density x serum urate levels interaction ( 34046847) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Triglyceride levels ( 32203549) Waist-hip ratio ( 30108283) Weight ( 28552196)
Interacting Genes		24 interacting genes: ASPH BAAT CCDC180 CTSV FANCC FBP2 HRAS MAP2K1 MAPK12 MAPK3 MBP NANS PFKM PPP2CB PPP3R2 RANGAP1 SFRP4 SMAD1 SPARCL1 TBC1D2 TGFB1 TMEM129 XPA ZNF510	57 interacting genes: ABI1 ABI2 AKAP9 ALG13 APP BACE2 BBS4 BICD2 CASK CCHCR1 CDC42 CDK1 CEBPA CEP72 CYTH4 DDIT3 DDX23 DENND1A DYNLL1 E2F4 ECPAS EPS8 EXOC8 FAM81A FXR2 GABARAP GOLGA2 GRN HAP1 ING5 INTS4 KAT5 KLC1 KLC4 KRT15 KRT19 KRT24 LARP4 LSM2 MCRS1 MORF4L1 NDUFA9 PCNT PPIE PRC1 PRKCI PRPF6 RALBP1 RBM11 RBM5 RINT1 RPA2 TFIP11 TTC8 VPS26C WASHC3 ZNF830
Entrez ID		5157	5108
HPRD ID		05206	02624
Ensembl ID		ENSG00000104213	ENSG00000078674
Uniprot IDs		Q15198	A0A4W8VX11 A0A5H1ZRS1 A2RUU9 B9EIS5 E9PGW9 Q15154
PDB IDs			6HYL 6HYM 7Q46
Enriched GO Terms of Interacting Partners?		Myelination Axon Ensheathment MAPK Cascade Regulation Of Intracellular Transport Glial Cell Development Schwann Cell Development Regulation Of Cellular Localization Regulation Of Golgi Inheritance Intracellular Signaling Cassette Trachea Formation Regulation Of Intracellular Protein Transport Fructose 1,6-bisphosphate Metabolic Process ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Regulation Of Establishment Of Protein Localization Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Catalytic Activity Bergmann Glial Cell Differentiation Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Positive Regulation Of ERK1 And ERK2 Cascade Chemical Homeostasis Cytosol Fructose 6-phosphate Metabolic Process Negative Regulation Of Immune Response To Tumor Cell Negative Regulation Of Cell-cell Adhesion Regulation Of Transport Regulation Of Protein Localization MAP Kinase Activity Positive Regulation Of Intracellular Protein Transport Regulation Of MiRNA Metabolic Process Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Regulation Of Golgi Organization Regulation Of Early Endosome To Late Endosome Transport Homeostatic Process Negative Regulation Of Transport Regulation Of Protein Transport Hematopoietic Or Lymphoid Organ Development Positive Regulation Of Protein Transport Animal Organ Formation Face Development Negative Regulation Of Cell Population Proliferation ERBB2 Signaling Pathway Intracellular Signal Transduction Gland Development Positive Regulation Of Hydrolase Activity Muscle Cell Cellular Homeostasis Regulation Of Protein Localization To Synapse Lung Morphogenesis	Cytoskeleton Organelle Organization Cytoskeleton Organization Microtubule-based Process Centrosome Supramolecular Fiber Organization Positive Regulation Of Organelle Organization Cytosol Spliceosomal Complex Microtubule Cytoskeleton Organization Centriolar Satellite Regulation Of Supramolecular Fiber Organization Growth Cone Microtubule Organizing Center Organization Regulation Of Organelle Organization Catalytic Step 2 Spliceosome Cellular Component Assembly Regulation Of Cell Cycle Cellular Response To Stress Microtubule Intracellular Protein Localization Positive Regulation Of Cellular Component Organization Establishment Of Protein Localization CHOP-C/EBP Complex Regulation Of Actin Filament Organization RNA Splicing Cytoplasm Cellular Localization Astrocyte Activation Involved In Immune Response Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Sensory Processing Regulation Of Attachment Of Spindle Microtubules To Kinetochore Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity MRNA Splicing, Via Spliceosome Histone Acetyltransferase Complex Epithelial Cell Differentiation Protein Transport Mitotic DNA Damage Checkpoint Signaling Regulation Of Cytoskeleton Organization RNA Splicing, Via Transesterification Reactions Mitotic DNA Integrity Checkpoint Signaling Positive Regulation Of Protein Metabolic Process Mitotic Spindle Microtubule Nucleation MRNA Processing Golgi Disassembly Nuclear DNA Replication Organelle Disassembly
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