PDGFA and COL3A1

Number of citations of the paper that reports this interaction (PubMedID 8900172)
0

Data Source:
BioGRID (pull down)

		PDGFA	COL3A1
Description		platelet derived growth factor subunit A	collagen type III alpha 1 chain
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Microvillus Cell Surface Membrane Platelet Alpha Granule Lumen Platelet-derived Growth Factor Complex Platelet-derived Growth Factor Receptor-ligand Complex	Extracellular Region Collagen Trimer Fibrillar Collagen Trimer Collagen Type III Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Platelet-derived Growth Factor Receptor Binding Protein Binding Collagen Binding Growth Factor Activity Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Receptor Ligand Activity Platelet-derived Growth Factor Binding	Protease Binding Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength SMAD Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Angiogenesis Cell Activation Hair Follicle Development Positive Regulation Of Mesenchymal Cell Proliferation Cell-cell Signaling Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Response To Wounding Animal Organ Morphogenesis Negative Regulation Of Phosphatidylinositol Biosynthetic Process Negative Regulation Of Platelet Activation Regulation Of Smooth Muscle Cell Migration Cell Projection Assembly Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Regulation Of Actin Cytoskeleton Organization Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Wound Healing Positive Regulation Of MAPK Cascade Skin Development Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Lung Alveolus Development Digestive Tract Development Negative Chemotaxis Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Bone Development Regulation Of Branching Involved In Salivary Gland Morphogenesis By Epithelial-mesenchymal Signaling Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Glomerular Mesangial Cell Proliferation Embryonic Lung Development Regulation Of DNA Biosynthetic Process	Blood Vessel Development In Utero Embryonic Development Neuron Migration Tissue Homeostasis Chondrocyte Differentiation Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Heart Development Response To Radiation Gene Expression Peptide Cross-linking Layer Formation In Cerebral Cortex Cerebral Cortex Development Platelet Activation Extracellular Matrix Organization Collagen Fibril Organization Lung Development Transforming Growth Factor Beta1 Production Response To Cytokine Positive Regulation Of Rho Protein Signal Transduction Multicellular Organism Growth Aorta Development Limb Joint Morphogenesis Wound Healing Skin Development Fibroblast Proliferation Elastic Fiber Assembly Animal Organ Development Digestive Tract Development System Development Negative Regulation Of Immune Response Cartilage Development Endochondral Bone Morphogenesis Aorta Smooth Muscle Tissue Morphogenesis Cellular Response To Amino Acid Stimulus Basement Membrane Organization Supramolecular Fiber Organization Response To Angiotensin Negative Regulation Of Neuron Migration
Pathways		Non-integrin membrane-ECM interactions NFE2L2 regulating tumorigenic genes	Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Scavenging by Class A Receptors NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization Developmental Lineage of Pancreatic Ductal Cells
Drugs			Collagenase clostridium histolyticum
Diseases		Glioma Malignant pleural mesothelioma	Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
GWAS		Male-pattern baldness ( 28196072)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Carotid intima media thickness x smoking interaction ( 32117412) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Parkinson disease and lewy body pathology ( 25663231) Platelet distribution width ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		17 interacting genes: A2M ASPH COL1A1 COL1A2 COL2A1 COL3A1 COL4A1 COL5A1 COL6A1 DUSP3 FURIN HSPG2 MBD3 MDFI PDAP1 PDGFRA SPARC	14 interacting genes: AP2B1 CAPN1 DDR1 DDR2 FGF7 HTRA1 MAG MYOC PCOLCE PDGFA PDGFB SPARC THBS1 VWF
Entrez ID		5154	1281
HPRD ID		01424	00365
Ensembl ID		ENSG00000197461	ENSG00000168542
Uniprot IDs		P04085	A0AAG2UVC5 P02461
PDB IDs		3MJK	2V53 3DMW 4AE2 4AEJ 4AK3 4GYX 6FZV 6FZW 7WWR 7WWS 7XAN
Enriched GO Terms of Interacting Partners?		Platelet-derived Growth Factor Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Fibrillar Collagen Trimer Extracellular Matrix Organization Extracellular Structure Organization Collagen Trimer Extracellular Matrix Extracellular Matrix Structural Constituent Collagen Fibril Organization Cellular Response To Amino Acid Stimulus Basement Membrane Response To Amino Acid Collagen Metabolic Process Endoplasmic Reticulum Lumen Anatomical Structure Morphogenesis Animal Organ Morphogenesis Extracellular Region Protease Binding Animal Organ Development Skin Development Developmental Process Collagen Type I Trimer Enzyme-linked Receptor Protein Signaling Pathway Extracellular Matrix Assembly Cartilage Development Face Morphogenesis Skeletal System Morphogenesis Basement Membrane Organization Anatomical Structure Formation Involved In Morphogenesis Collagen Type XI Trimer Blood Vessel Development Limb Joint Morphogenesis System Development Extracellular Space Cell Surface Receptor Signaling Pathway Tissue Development Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Roof Of Mouth Development Collagen Biosynthetic Process Skin Morphogenesis Embryonic Skeletal System Morphogenesis Proteoglycan Binding Collagen-activated Signaling Pathway Biomineral Tissue Development Transforming Growth Factor Beta Receptor Signaling Pathway Lung Development Cell Differentiation Cartilage Development Involved In Endochondral Bone Morphogenesis Embryonic Organ Morphogenesis Ossification	Collagen Binding Platelet Alpha Granule Lumen Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Extracellular Space Extracellular Region Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Protein Tyrosine Kinase Collagen Receptor Activity Response To Wounding Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Platelet Alpha Granule Extracellular Matrix Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of Phosphorylation Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Extracellular Matrix Structural Constituent Regulation Of Body Fluid Levels Positive Regulation Of Cell Population Proliferation Positive Regulation Of Phosphate Metabolic Process Regulation Of Wound Healing Regulation Of Cellular Component Organization Negative Regulation Of Phospholipid Biosynthetic Process Regulation Of Endothelial Cell Proliferation Animal Organ Development Regulation Of Cell Migration Enzyme-linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Regulation Of Cell Motility Regulation Of MAPK Cascade Regulation Of Response To Wounding Regulation Of Locomotion Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Signal Transduction Regulation Of Branching Involved In Salivary Gland Morphogenesis Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Phosphorylation Regulation Of Blood Coagulation Regulation Of Cell-substrate Adhesion Regulation Of Hemostasis Regulation Of Smooth Muscle Cell Migration Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Regulation Of Signal Transduction
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