PDGFA and COL3A1

Number of citations of the paper that reports this interaction (PMID 8900172)
4

Data Source:
BioGRID (pull down)

		PDGFA	COL3A1
Gene Name		platelet-derived growth factor alpha polypeptide	collagen, type III, alpha 1
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Microvillus Cell Surface Platelet Alpha Granule Lumen	Extracellular Region Collagen Type III Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Platelet-derived Growth Factor Receptor Binding Protein Binding Collagen Binding Growth Factor Activity Protein Homodimerization Activity Protein Heterodimerization Activity Platelet-derived Growth Factor Binding	Integrin Binding Extracellular Matrix Structural Constituent Protein Binding SMAD Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Angiogenesis Response To Hypoxia Cell Activation Hair Follicle Development Positive Regulation Of Mesenchymal Cell Proliferation Platelet Degranulation Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Blood Coagulation Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Response To Wounding Organ Morphogenesis Response To Inorganic Substance Negative Regulation Of Phosphatidylinositol Biosynthetic Process Negative Regulation Of Platelet Activation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Smooth Muscle Cell Migration Cell Projection Assembly Actin Cytoskeleton Organization Platelet Activation Extracellular Matrix Organization Positive Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Response To Estradiol Response To Retinoic Acid Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Fc-epsilon Receptor Signaling Pathway Wound Healing Response To Drug Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Skin Development Innate Immune Response Positive Regulation Of DNA Replication Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation Lung Alveolus Development Inner Ear Development Regulation Of Peptidyl-tyrosine Phosphorylation Negative Chemotaxis Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling Regulation Of Branching Involved In Salivary Gland Morphogenesis By Epithelial-mesenchymal Signaling Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Glomerular Mesangial Cell Proliferation Embryonic Lung Development Regulation Of DNA Biosynthetic Process	Skeletal System Development Receptor-mediated Endocytosis Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Axon Guidance Heart Development Aging Response To Radiation Response To Mechanical Stimulus Peptide Cross-linking Cerebral Cortex Development Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process Response To Cytokine Positive Regulation Of Rho Protein Signal Transduction Wound Healing Extracellular Fibril Organization Skin Development Digestive Tract Development Negative Regulation Of Immune Response Aorta Smooth Muscle Tissue Morphogenesis Cellular Response To Amino Acid Stimulus Negative Regulation Of Neuron Migration
Pathways		Signaling by PDGF Non-integrin membrane-ECM interactions	Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Syndecan interactions ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth Scavenging by Class A Receptors
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: A2M COL1A1 COL1A2 COL2A1 COL3A1 COL4A1 COL5A1 COL6A1 DUSP3 FURIN HSPG2 PDAP1 PDGFRA SPARC	12 interactors: CAPN1 DDR1 DDR2 FGF7 HTRA1 MAG MYOC PCOLCE PDGFA PDGFB SPARC THBS1
Entrez ID		5154	1281
HPRD ID		01424	00365
Ensembl ID		ENSG00000197461	ENSG00000168542
Uniprot IDs		P04085 Q32M96	P02461
PDB IDs		3MJK	2V53 3DMW 4AE2 4AEJ 4AK3 4GYX
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Cellular Response To Amino Acid Stimulus Response To Amino Acid Cardiovascular System Development Collagen Fibril Organization Cellular Response To Growth Factor Stimulus Cellular Response To Acid Chemical Response To Growth Factor Platelet Activation Blood Vessel Development Cellular Response To Organic Substance Vasculature Development Skeletal System Development Wound Healing Protein Heterotrimerization Response To Wounding Blood Coagulation Hemostasis Catabolic Process Response To Organic Substance Response To External Stimulus Locomotion Cellular Response To Organonitrogen Compound Response To Organonitrogen Compound Heart Development Response To Stimulus Ossification Movement Of Cell Or Subcellular Component Regulation Of Body Fluid Levels Organ Morphogenesis Chemotaxis Cellular Response To Stimulus Protein Trimerization Cartilage Development Involved In Endochondral Bone Morphogenesis Receptor-mediated Endocytosis Cell Activation Developmental Process Anatomical Structure Morphogenesis Tissue Development Endochondral Ossification Axon Guidance Embryonic Skeletal System Development Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta	Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cell Proliferation Regulation Of Cell Migration Regulation Of Cell Motility Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Locomotion Response To Wounding Regulation Of Cellular Component Movement Regulation Of Cellular Component Organization Platelet Degranulation Organ Development Positive Regulation Of Epithelial Cell Migration Enzyme Linked Receptor Protein Signaling Pathway Organ Morphogenesis Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Wound Healing Regulation Of Epithelial Cell Proliferation Response To Growth Factor Multicellular Organismal Development Negative Regulation Of Phosphatidylinositol Biosynthetic Process Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Secretion Regulation Of Epithelial Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Developmental Process ERBB Signaling Pathway Blood Coagulation Collagen-activated Signaling Pathway Negative Regulation Of Phospholipid Biosynthetic Process System Development Positive Regulation Of Cell Proliferation Hemostasis Platelet Activation Positive Regulation Of Endothelial Cell Migration Neurotrophin TRK Receptor Signaling Pathway Platelet-derived Growth Factor Receptor-beta Signaling Pathway Secretion By Cell Neurotrophin Signaling Pathway Bone Development Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Anatomical Structure Development Positive Regulation Of Protein Kinase B Signaling
Tagcloud ?		apply autocrine bring brodaly building categorically col1a1 connectivity disconnected exclusive formula gaussian graph graphical heterogenous implies lrps mix mutually organized postulate prioritize prognostically reproduced reproducible see text uncovering	abrogation adenomas alcoholic ccl3 col1a2 compromised confirming fibrotic fivefold gh ghr ghrld hepatic hyperlipidemia livers microscopic mup1 nafld proteomics qpcr selenbp2 socs2 socs3 steatosis superarray tgfbeta threefold tolerance unravel
Tagcloud (Difference) ?		apply autocrine bring brodaly building categorically col1a1 connectivity disconnected exclusive formula gaussian graph graphical heterogenous implies lrps mix mutually organized postulate prioritize prognostically reproduced reproducible see text uncovering	abrogation adenomas alcoholic ccl3 col1a2 compromised confirming fibrotic fivefold gh ghr ghrld hepatic hyperlipidemia livers microscopic mup1 nafld proteomics qpcr selenbp2 socs2 socs3 steatosis superarray tgfbeta threefold tolerance unravel
Tagcloud (Intersection) ?