PDGFA and PDAP1

Number of citations of the paper that reports this interaction (PubMedID 8780057)
0

Data Source:
HPRD (in vitro)

		PDGFA	PDAP1
Description		platelet derived growth factor subunit A	PDGFA associated protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Microvillus Cell Surface Membrane Platelet Alpha Granule Lumen Platelet-derived Growth Factor Complex Platelet-derived Growth Factor Receptor-ligand Complex	Extracellular Region Cytosol Plasma Membrane Ficolin-1-rich Granule Lumen
	Molecular Function	Platelet-derived Growth Factor Receptor Binding Protein Binding Collagen Binding Growth Factor Activity Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Receptor Ligand Activity Platelet-derived Growth Factor Binding	RNA Binding Protein Binding
	Biological Process	Angiogenesis Cell Activation Hair Follicle Development Positive Regulation Of Mesenchymal Cell Proliferation Cell-cell Signaling Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Response To Wounding Animal Organ Morphogenesis Negative Regulation Of Phosphatidylinositol Biosynthetic Process Negative Regulation Of Platelet Activation Regulation Of Smooth Muscle Cell Migration Cell Projection Assembly Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Regulation Of Actin Cytoskeleton Organization Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Wound Healing Positive Regulation Of MAPK Cascade Skin Development Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Lung Alveolus Development Digestive Tract Development Negative Chemotaxis Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Bone Development Regulation Of Branching Involved In Salivary Gland Morphogenesis By Epithelial-mesenchymal Signaling Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Glomerular Mesangial Cell Proliferation Embryonic Lung Development Regulation Of DNA Biosynthetic Process	Signal Transduction
Pathways		Non-integrin membrane-ECM interactions NFE2L2 regulating tumorigenic genes	Neutrophil degranulation
Drugs
Diseases		Glioma Malignant pleural mesothelioma
GWAS		Male-pattern baldness ( 28196072)	Facial emotion recognition (sad faces) ( 28608620) Mean spheric corpuscular volume ( 32888494) Serum metabolite levels ( 23093944)
Interacting Genes		17 interacting genes: A2M ASPH COL1A1 COL1A2 COL2A1 COL3A1 COL4A1 COL5A1 COL6A1 DUSP3 FURIN HSPG2 MBD3 MDFI PDAP1 PDGFRA SPARC	9 interacting genes: APP CEBPA CSNK2A1 CWC22 FZD7 PDGFA PDGFB PDGFRB SF1
Entrez ID		5154	11333
HPRD ID		01424	06149
Ensembl ID		ENSG00000197461	ENSG00000106244
Uniprot IDs		P04085	Q13442
PDB IDs		3MJK
Enriched GO Terms of Interacting Partners?		Platelet-derived Growth Factor Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Fibrillar Collagen Trimer Extracellular Matrix Organization Extracellular Structure Organization Collagen Trimer Extracellular Matrix Extracellular Matrix Structural Constituent Collagen Fibril Organization Cellular Response To Amino Acid Stimulus Basement Membrane Response To Amino Acid Collagen Metabolic Process Endoplasmic Reticulum Lumen Anatomical Structure Morphogenesis Animal Organ Morphogenesis Extracellular Region Protease Binding Animal Organ Development Skin Development Developmental Process Collagen Type I Trimer Enzyme-linked Receptor Protein Signaling Pathway Extracellular Matrix Assembly Cartilage Development Face Morphogenesis Skeletal System Morphogenesis Basement Membrane Organization Anatomical Structure Formation Involved In Morphogenesis Collagen Type XI Trimer Blood Vessel Development Limb Joint Morphogenesis System Development Extracellular Space Cell Surface Receptor Signaling Pathway Tissue Development Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Roof Of Mouth Development Collagen Biosynthetic Process Skin Morphogenesis Embryonic Skeletal System Morphogenesis Proteoglycan Binding Collagen-activated Signaling Pathway Biomineral Tissue Development Transforming Growth Factor Beta Receptor Signaling Pathway Lung Development Cell Differentiation Cartilage Development Involved In Endochondral Bone Morphogenesis Embryonic Organ Morphogenesis Ossification	Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Platelet-derived Growth Factor Receptor-beta Signaling Pathway Platelet-derived Growth Factor Binding Platelet-derived Growth Factor Receptor Binding Regulation Of Cell Population Proliferation Positive Regulation Of Phosphate Metabolic Process Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Phospholipid Biosynthetic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphorus Metabolic Process Platelet Alpha Granule Lumen Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Protein Autophosphorylation Smooth Muscle Adaptation Positive Regulation Of Phosphorylation Regulation Of Smooth Muscle Cell Migration Cell Surface Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA Biosynthetic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Primary Metabolic Process Regulation Of Glomerular Mesangial Cell Proliferation Chemotaxis Golgi Lumen Protein Heterodimerization Activity Regulation Of Protein Autophosphorylation Locomotion Regulation Of Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Receptor Ligand Activity Regulation Of Phospholipid Biosynthetic Process Negative Regulation Of Platelet Activation Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Chemotaxis Regulation Of Smooth Muscle Cell Proliferation Cellular Response To Platelet-derived Growth Factor Stimulus Embryonic Organ Development Response To Platelet-derived Growth Factor
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