PDGFA

Description		platelet derived growth factor subunit A
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Microvillus Cell Surface Membrane Platelet Alpha Granule Lumen Platelet-derived Growth Factor Complex Platelet-derived Growth Factor Receptor-ligand Complex
	Molecular Function	Platelet-derived Growth Factor Receptor Binding Protein Binding Collagen Binding Growth Factor Activity Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Receptor Ligand Activity Platelet-derived Growth Factor Binding
	Biological Process	Angiogenesis Cell Activation Hair Follicle Development Positive Regulation Of Mesenchymal Cell Proliferation Cell-cell Signaling Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Response To Wounding Animal Organ Morphogenesis Negative Regulation Of Phosphatidylinositol Biosynthetic Process Negative Regulation Of Platelet Activation Regulation Of Smooth Muscle Cell Migration Cell Projection Assembly Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Regulation Of Actin Cytoskeleton Organization Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Wound Healing Positive Regulation Of MAPK Cascade Skin Development Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Lung Alveolus Development Digestive Tract Development Negative Chemotaxis Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Bone Development Regulation Of Branching Involved In Salivary Gland Morphogenesis By Epithelial-mesenchymal Signaling Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Glomerular Mesangial Cell Proliferation Embryonic Lung Development Regulation Of DNA Biosynthetic Process
Pathways		Non-integrin membrane-ECM interactions NFE2L2 regulating tumorigenic genes
Drugs
Diseases		Glioma Malignant pleural mesothelioma
GWAS		Male-pattern baldness ( 28196072)
Interacting Genes		17 interacting genes: A2M ASPH COL1A1 COL1A2 COL2A1 COL3A1 COL4A1 COL5A1 COL6A1 DUSP3 FURIN HSPG2 MBD3 MDFI PDAP1 PDGFRA SPARC
Entrez ID		5154
HPRD ID		01424
Ensembl ID		ENSG00000197461
Uniprot IDs		P04085
PDB IDs		3MJK
Enriched GO Terms of Interacting Partners?		Platelet-derived Growth Factor Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Fibrillar Collagen Trimer Extracellular Matrix Organization Extracellular Structure Organization Collagen Trimer Extracellular Matrix Extracellular Matrix Structural Constituent Collagen Fibril Organization Cellular Response To Amino Acid Stimulus Basement Membrane Response To Amino Acid Collagen Metabolic Process Endoplasmic Reticulum Lumen Anatomical Structure Morphogenesis Animal Organ Morphogenesis Extracellular Region Protease Binding Animal Organ Development Skin Development Developmental Process Collagen Type I Trimer Enzyme-linked Receptor Protein Signaling Pathway Extracellular Matrix Assembly Cartilage Development Face Morphogenesis Skeletal System Morphogenesis Basement Membrane Organization Anatomical Structure Formation Involved In Morphogenesis Collagen Type XI Trimer Blood Vessel Development Limb Joint Morphogenesis System Development Extracellular Space Cell Surface Receptor Signaling Pathway Tissue Development Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Roof Of Mouth Development Collagen Biosynthetic Process Skin Morphogenesis Embryonic Skeletal System Morphogenesis Proteoglycan Binding Collagen-activated Signaling Pathway Biomineral Tissue Development Transforming Growth Factor Beta Receptor Signaling Pathway Lung Development Cell Differentiation Cartilage Development Involved In Endochondral Bone Morphogenesis Embryonic Organ Morphogenesis Ossification
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