PDGFA

Gene Name		platelet-derived growth factor alpha polypeptide
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Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Microvillus Cell Surface Platelet Alpha Granule Lumen
	Molecular Function	Platelet-derived Growth Factor Receptor Binding Protein Binding Collagen Binding Growth Factor Activity Protein Homodimerization Activity Protein Heterodimerization Activity Platelet-derived Growth Factor Binding
	Biological Process	Angiogenesis Response To Hypoxia Cell Activation Hair Follicle Development Positive Regulation Of Mesenchymal Cell Proliferation Platelet Degranulation Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Blood Coagulation Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Response To Wounding Organ Morphogenesis Response To Inorganic Substance Negative Regulation Of Phosphatidylinositol Biosynthetic Process Negative Regulation Of Platelet Activation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Smooth Muscle Cell Migration Cell Projection Assembly Actin Cytoskeleton Organization Platelet Activation Extracellular Matrix Organization Positive Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Response To Estradiol Response To Retinoic Acid Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Fc-epsilon Receptor Signaling Pathway Wound Healing Response To Drug Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Skin Development Innate Immune Response Positive Regulation Of DNA Replication Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation Lung Alveolus Development Inner Ear Development Regulation Of Peptidyl-tyrosine Phosphorylation Negative Chemotaxis Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling Regulation Of Branching Involved In Salivary Gland Morphogenesis By Epithelial-mesenchymal Signaling Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Glomerular Mesangial Cell Proliferation Embryonic Lung Development Regulation Of DNA Biosynthetic Process
Pathways		Signaling by PDGF Non-integrin membrane-ECM interactions
Drugs
Diseases
GWAS
Protein-protein Interactions		14 interactors: A2M COL1A1 COL1A2 COL2A1 COL3A1 COL4A1 COL5A1 COL6A1 DUSP3 FURIN HSPG2 PDAP1 PDGFRA SPARC
Entrez ID		5154
HPRD ID		01424
Ensembl ID		ENSG00000197461
Uniprot IDs		P04085 Q32M96
PDB IDs		3MJK
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Cellular Response To Amino Acid Stimulus Response To Amino Acid Cardiovascular System Development Collagen Fibril Organization Cellular Response To Growth Factor Stimulus Cellular Response To Acid Chemical Response To Growth Factor Platelet Activation Blood Vessel Development Cellular Response To Organic Substance Vasculature Development Skeletal System Development Wound Healing Protein Heterotrimerization Response To Wounding Blood Coagulation Hemostasis Catabolic Process Response To Organic Substance Response To External Stimulus Locomotion Cellular Response To Organonitrogen Compound Response To Organonitrogen Compound Heart Development Response To Stimulus Ossification Movement Of Cell Or Subcellular Component Regulation Of Body Fluid Levels Organ Morphogenesis Chemotaxis Cellular Response To Stimulus Protein Trimerization Cartilage Development Involved In Endochondral Bone Morphogenesis Receptor-mediated Endocytosis Cell Activation Developmental Process Anatomical Structure Morphogenesis Tissue Development Endochondral Ossification Axon Guidance Embryonic Skeletal System Development Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta
Tagcloud ?		apply autocrine bring brodaly building categorically col1a1 connectivity disconnected exclusive formula gaussian graph graphical heterogenous implies lrps mix mutually organized postulate prioritize prognostically reproduced reproducible see text uncovering