PDGFA and COL5A1

Number of citations: 0 (PubMedID 8900172)
Data Source: BioGRID (pull down)

		PDGFA	COL5A1
Name		platelet derived growth factor subunit A	collagen type V alpha 1 chain
Structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Microvillus Cell Surface Membrane Platelet Alpha Granule Lumen Platelet-derived Growth Factor Complex Platelet-derived Growth Factor Receptor-ligand Complex	Extracellular Region Collagen Trimer Fibrillar Collagen Trimer Collagen Type V Trimer Collagen Type XI Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Platelet-derived Growth Factor Receptor Binding Protein Binding Collagen Binding Growth Factor Activity Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Receptor Ligand Activity Platelet-derived Growth Factor Binding	Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Heparin Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Proteoglycan Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Angiogenesis Cell Activation Hair Follicle Development Positive Regulation Of Mesenchymal Cell Proliferation Cell-cell Signaling Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Response To Wounding Animal Organ Morphogenesis Negative Regulation Of Phosphatidylinositol Biosynthetic Process Negative Regulation Of Platelet Activation Regulation Of Smooth Muscle Cell Migration Cell Projection Assembly Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Regulation Of Actin Cytoskeleton Organization Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Wound Healing Positive Regulation Of MAPK Cascade Skin Development Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Lung Alveolus Development Digestive Tract Development Negative Chemotaxis Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Bone Development Regulation Of Branching Involved In Salivary Gland Morphogenesis By Epithelial-mesenchymal Signaling Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Glomerular Mesangial Cell Proliferation Embryonic Lung Development Regulation Of DNA Biosynthetic Process	Blood Vessel Development Heart Morphogenesis Cell Adhesion Cell Migration Collagen Fibril Organization Collagen Biosynthetic Process Wound Healing, Spreading Of Epidermal Cells Tendon Development Skin Development Integrin Biosynthetic Process Eye Morphogenesis Regulation Of Cellular Component Organization Supramolecular Fiber Organization Negative Regulation Of Endodermal Cell Differentiation
Pathways		Non-integrin membrane-ECM interactions NFE2L2 regulating tumorigenic genes	Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization Attachment of bacteria to epithelial cells Developmental Lineage of Pancreatic Ductal Cells
Diseases		Glioma Malignant pleural mesothelioma	Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
GWAS		Male-pattern baldness ( 28196072 )	Blood pressure ( 24954895 ) Central corneal thickness ( 20719862 22814818 23493294 32528159 28171582 31798171 29760442 30894546 ) Corneal structure ( 23291589 ) Crohn's disease (need for surgery) ( 23665963 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Intraocular pressure ( 29617998 ) Keratoconus ( 33649486 ) Longevity ( 20834067 ) Metabolite levels ( 23823483 ) Phosphatidylcholine levels ( 31551469 ) Refractive error ( 32231278 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		17 interacting genes: A2M ASPH COL1A1 COL1A2 COL2A1 COL3A1 COL4A1 COL5A1 COL6A1 DUSP3 FURIN HSPG2 MBD3 MDFI PDAP1 PDGFRA SPARC	10 interacting genes: BMP1 COL5A3 DCN LGALS3BP MAG PDGFA PDGFB SDC3 SPARC THBS1
Entrez ID		5154	1289
HPRD ID		01424	00368
Ensembl ID		ENSG00000197461	ENSG00000130635
Uniprot IDs		P04085	B2ZZ86 P20908 Q59EE7
PDB IDs		3MJK	7Y37
GO Terms Enriched among Interactors		Platelet-derived Growth Factor Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Fibrillar Collagen Trimer Extracellular Matrix Organization Extracellular Structure Organization Collagen Trimer Extracellular Matrix Extracellular Matrix Structural Constituent Collagen Fibril Organization Cellular Response To Amino Acid Stimulus Basement Membrane Response To Amino Acid Collagen Metabolic Process Endoplasmic Reticulum Lumen Anatomical Structure Morphogenesis Animal Organ Morphogenesis Extracellular Region Protease Binding Animal Organ Development Skin Development Developmental Process Collagen Type I Trimer Enzyme-linked Receptor Protein Signaling Pathway Extracellular Matrix Assembly Cartilage Development Face Morphogenesis Skeletal System Morphogenesis Basement Membrane Organization Anatomical Structure Formation Involved In Morphogenesis Collagen Type XI Trimer Blood Vessel Development Limb Joint Morphogenesis System Development Extracellular Space Cell Surface Receptor Signaling Pathway Tissue Development Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Roof Of Mouth Development Collagen Biosynthetic Process Skin Morphogenesis Embryonic Skeletal System Morphogenesis Proteoglycan Binding Collagen-activated Signaling Pathway Biomineral Tissue Development Transforming Growth Factor Beta Receptor Signaling Pathway Lung Development Cell Differentiation Cartilage Development Involved In Endochondral Bone Morphogenesis Embryonic Organ Morphogenesis Ossification	Extracellular Matrix Collagen Binding Platelet Alpha Granule Lumen Golgi Lumen Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Extracellular Matrix Binding Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Extracellular Region Extracellular Space Regulation Of Endothelial Cell Migration Negative Regulation Of Phospholipid Biosynthetic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Autophosphorylation Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Hemostasis Regulation Of Blood Coagulation Negative Regulation Of Multicellular Organismal Process Platelet-derived Growth Factor Binding Cell Surface Regulation Of Glomerular Mesangial Cell Proliferation Endoplasmic Reticulum Lumen Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Protein Autophosphorylation Proteoglycan Binding Platelet-derived Growth Factor Receptor Binding Extracellular Matrix Structural Constituent Positive Regulation Of Endothelial Cell Migration Regulation Of Phospholipid Biosynthetic Process Negative Regulation Of Platelet Activation Platelet Alpha Granule Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Regulation Of Wound Healing Regulation Of Anatomical Structure Morphogenesis Regulation Of Endothelial Cell Proliferation Growth Factor Activity Regulation Of Developmental Process Negative Regulation Of Developmental Process Regulation Of Cell Migration Regulation Of Response To Wounding Regulation Of Cell Motility Regulation Of Locomotion Response To Wounding Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Phospholipid Metabolic Process Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion