STAC and LMNA

Number of citations of the paper that reports this interaction (PMID 18654987)
7

Data Source:
BioGRID (two hybrid)

		STAC	LMNA
Gene Name		SH3 and cysteine rich domain	lamin A/C
Image
Gene Ontology Annotations	Cellular Component	Cytosol	Nucleus Nuclear Envelope Lamin Filament Nuclear Lamina Nucleoplasm Cytoplasm Cytosol Intermediate Filament Nuclear Speck Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Metal Ion Binding	Structural Molecule Activity Protein Binding
	Biological Process	Signal Transduction Cellular Response To Heat Intracellular Signal Transduction	Mitotic Cell Cycle Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Mitotic Nuclear Envelope Disassembly Mitotic Nuclear Envelope Reassembly Muscle Organ Development Regulation Of Cell Migration Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Endoplasmic Reticulum Unfolded Protein Response Protein Localization To Nucleus Sterol Regulatory Element Binding Protein Import Into Nucleus Cellular Protein Metabolic Process Ventricular Cardiac Muscle Cell Development Cellular Response To Hypoxia Negative Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Cell Aging Regulation Of Protein Localization To Nucleus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			IRE1alpha activates chaperones XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS		Erectile dysfunction ( 22704111)
Protein-Protein Interactions		11 interactors: APP C9orf156 FBXO25 KANK2 KIAA1958 LIMD1 LMNA LZTS2 NCKIPSD NEDD4L TRIP6	43 interactors: ACTB ALOX12 ALOX12B CASP1 CASP6 CDK1 DBNL DUSP13 EGF EMD FLNA FOS GZMA GZMB KAT5 KRTAP10-3 KRTAP10-7 LMNB1 MLIP MRPS26 NARF PCBP1 PCGF2 PRKCA RB1 RBBP4 SH3KBP1 SMAD3 SREBF1 STAC SUMO4 SVIL SYNE1 TMPO TOR1A TOR1AIP1 UBE2I UCHL5 UNC13D URB2 VAV1 YWHAQ ZNF239
Entrez ID		6769	4000
HPRD ID		11890	01035
Ensembl ID		ENSG00000144681	ENSG00000160789
Uniprot IDs		E9PEA7 Q99469	P02545
PDB IDs		2DL4	1IFR 1IVT 1X8Y 2XV5 2YPT 3GEF 3V4Q 3V4W 3V5B
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Signaling Negative Regulation Of Signaling Regulation Of Protein Localization To Nucleus Nucleocytoplasmic Transport Nuclear Transport Regulation Of Protein Localization Sterol Regulatory Element Binding Protein Import Into Nucleus Regulation Of Cellular Localization Response To Abiotic Stimulus Cytoskeleton Organization Negative Regulation Of Vitamin D Receptor Signaling Pathway Synaptic Growth At Neuromuscular Junction Positive Regulation Of Caveolin-mediated Endocytosis Protein Import Into Nucleus Nuclear Import Collateral Sprouting In Absence Of Injury Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Signal Transduction Positive Regulation Of Gene Silencing By MiRNA Negative Regulation Of Canonical Wnt Signaling Pathway Protein Import Release Of Cytoplasmic Sequestered NF-kappaB Collateral Sprouting Axon Midline Choice Point Recognition Protein Localization To Nucleus Regulation Of Vitamin D Receptor Signaling Pathway Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Negative Regulation Of Hippo Signaling Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Caveolin-mediated Endocytosis Signaling Regulation Of Cellular Component Movement Cytoplasmic Transport Intracellular Transport Cell Communication Axon Choice Point Recognition Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Wnt Signaling Pathway Microtubule-based Process Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Tight Junction Assembly Regulation Of Hippo Signaling Positive Regulation Of Cell Aging Regulation Of Transcription, DNA-templated Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Canonical Wnt Signaling Pathway Regulation Of Nucleic Acid-templated Transcription	Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Protein Localization Regulation Of Cellular Localization Positive Regulation Of Transport Nucleus Organization Nuclear Envelope Organization Regulation Of Signaling Regulation Of Establishment Of Protein Localization Positive Regulation Of Intracellular Transport Regulation Of Intracellular Transport Regulation Of Signal Transduction Organelle Organization Positive Regulation Of Nucleocytoplasmic Transport Enzyme Linked Receptor Protein Signaling Pathway Response To Stress Cellular Response To Growth Factor Stimulus Positive Regulation Of Signal Transduction Response To Growth Factor Immune Response Cellular Response To Organic Substance Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Transport Regulation Of Catenin Import Into Nucleus Epidermal Growth Factor Receptor Signaling Pathway Execution Phase Of Apoptosis ERBB Signaling Pathway Positive Regulation Of Proteolysis Regulation Of Protein Import Into Nucleus Positive Regulation Of Cellular Protein Metabolic Process Organ Development Cellular Response To Stimulus Response To Wounding Platelet Activation Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Transport Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Anatomical Structure Development Regulation Of Nucleocytoplasmic Transport Immune System Process Nuclear Membrane Organization Mitotic Nuclear Envelope Disassembly Intracellular Signal Transduction Positive Regulation Of Protein Localization To Nucleus Hepoxilin Metabolic Process Hepoxilin Biosynthetic Process
Tagcloud ?		17p 1p36 1q 1q13 1q21 4q21 7p 7q 8p 8q 8q11 9p aspscr1 cirrhotic etv1and ffpe fgfr3 gains hcc hccs maf nearby pathologically pter q23 q26 recql4 xp xq	1824c acro affiliated alopecia bossing chin clavicles contracture extremities g608g gilford groove hgps horse huazhong hutchinson joints micrognathia midline osteolysis phalanges progeria radiographical riding sclerodermatous stance stature tongji x10
Tagcloud (Difference) ?		17p 1p36 1q 1q13 1q21 4q21 7p 7q 8p 8q 8q11 9p aspscr1 cirrhotic etv1and ffpe fgfr3 gains hcc hccs maf nearby pathologically pter q23 q26 recql4 xp xq	1824c acro affiliated alopecia bossing chin clavicles contracture extremities g608g gilford groove hgps horse huazhong hutchinson joints micrognathia midline osteolysis phalanges progeria radiographical riding sclerodermatous stance stature tongji x10
Tagcloud (Intersection) ?