PIK3R5 and PIK3CG

Number of citations of the paper that reports this interaction (PMID 12507995)
54

Data Source:
HPRD (in vivo)

		PIK3R5	PIK3CG
Gene Name		phosphoinositide-3-kinase, regulatory subunit 5	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Phosphatidylinositol 3-kinase Complex, Class IB Membrane	Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex, Class IB Membrane Mast Cell Granule
	Molecular Function	G-protein Beta/gamma-subunit Complex Binding 1-phosphatidylinositol-3-kinase Regulator Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding 1-phosphatidylinositol-3-kinase Activity Phosphatidylinositol 3-kinase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Ephrin Receptor Binding Phosphatidylinositol-4,5-bisphosphate 3-kinase Activity
	Biological Process	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process G-protein Coupled Receptor Signaling Pathway Blood Coagulation Phosphatidylinositol 3-kinase Signaling Platelet Activation Positive Regulation Of MAP Kinase Activity Regulation Of Phosphatidylinositol 3-kinase Activity Small Molecule Metabolic Process Positive Regulation Of Protein Kinase B Signaling	Angiogenesis Cytokine Production Adaptive Immune Response Dendritic Cell Chemotaxis Positive Regulation Of Acute Inflammatory Response Respiratory Burst Involved In Defense Response Protein Phosphorylation Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Endocytosis Inflammatory Response G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation T Cell Chemotaxis Negative Regulation Of Triglyceride Catabolic Process Phosphatidylinositol 3-kinase Signaling Platelet Activation Neutrophil Chemotaxis Secretory Granule Localization Regulation Of Cell Adhesion Mediated By Integrin Natural Killer Cell Chemotaxis Phosphatidylinositol-3-phosphate Biosynthetic Process T Cell Proliferation T Cell Activation Mast Cell Degranulation Positive Regulation Of MAP Kinase Activity Small Molecule Metabolic Process Innate Immune Response Phosphatidylinositol Phosphorylation Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Cardiac Muscle Contraction Platelet Aggregation Neutrophil Extravasation Hepatocyte Apoptotic Process Negative Regulation Of Fibroblast Apoptotic Process
Pathways		Synthesis of PIPs at the plasma membrane Signaling by GPCR GPCR downstream signaling Metabolism of lipids and lipoproteins G-protein beta:gamma signalling G beta:gamma signalling through PI3Kgamma GPVI-mediated activation cascade Phospholipid metabolism Platelet activation, signaling and aggregation PI Metabolism	Synthesis of PIPs at the plasma membrane Signaling by GPCR GPCR downstream signaling Metabolism of lipids and lipoproteins G-protein beta:gamma signalling G beta:gamma signalling through PI3Kgamma GPVI-mediated activation cascade Phospholipid metabolism Platelet activation, signaling and aggregation PI Metabolism
Drugs			Staurosporine Myricetin 2-(4-Morpholinyl)-8-Phenyl-4h-1-Benzopyran-4-One Quercetin 5-QUINOXALIN-6-YLMETHYLENE-THIAZOLIDINE-2,4-DIONE 2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE 5,5-dimethyl-2-morpholin-4-yl-5,6-dihydro-1,3-benzothiazol-7(4H)-one 3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL (5E)-5-[(2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)METHYLENE]-1,3-THIAZOLIDINE-2,4-DIONE (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE 1-methyl-3-naphthalen-2-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Diseases
GWAS			Blood pressure ( 21909110) Carotid intima media thickness ( 21909108) Mean platelet volume ( 22139419 19820697 22423221) Platelet counts ( 22139419)
Protein-Protein Interactions		3 interactors: APP PIK3CG SDHB	22 interactors: ADRBK1 BCR CD28 EPHA8 GAB1 GRB2 GSN HRAS IL6ST KIT KRAS LYN NOTCH1 NRAS PIK3CD PIK3R5 PTPN11 SEC14L2 SET SMPD2 TPM2 ZNF282
Entrez ID		23533	5294
HPRD ID		11433	03135
Ensembl ID		ENSG00000141506	ENSG00000105851
Uniprot IDs		J3KSW1 L7RT34 Q8WYR1	A8K9G9 P48736
PDB IDs			1E8Y 1E8Z 1HE8 2A4Z 2A5U 2CHW 2CHX 2CHZ 2V4L 3APC 3APD 3APF 3CSF 3CST 3DBS 3DPD 3ENE 3IBE 3L08 3L13 3L16 3L17 3L54 3LJ3 3MJW 3ML8 3ML9 3NZS 3NZU 3OAW 3P2B 3PRE 3PRZ 3PS6 3QAQ 3QAR 3QJZ 3QK0 3R7Q 3R7R 3S2A 3SD5 3T8M 3TJP 3TL5 3ZVV 3ZW3 4ANU 4ANV 4ANW 4ANX 4AOF 4DK5 4EZJ 4EZK 4EZL 4F1S 4FA6 4FAD 4FHJ 4FHK 4FJY 4FJZ 4FLH 4FUL 4G11 4GB9 4HLE 4KZ0 4KZC
Enriched GO Terms of Interacting Partners?		Platelet Activation Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Natural Killer Cell Chemotaxis Cellular Calcium Ion Homeostasis Negative Regulation Of Triglyceride Catabolic Process Neutrophil Extravasation Calcium Ion Homeostasis Collateral Sprouting Axon Midline Choice Point Recognition Respiratory Burst Involved In Defense Response Negative Regulation Of Cardiac Muscle Contraction Exocytosis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Cellular Metal Ion Homeostasis Negative Regulation Of Striated Muscle Contraction Blood Coagulation Hemostasis Small Molecule Metabolic Process Secretory Granule Localization Cellular Cation Homeostasis Cellular Ion Homeostasis Neuron Remodeling T Cell Chemotaxis Metal Ion Homeostasis Succinate Metabolic Process Secretion By Cell Negative Regulation Of Fibroblast Apoptotic Process Cellular Chemical Homeostasis Respiratory Burst Ion Homeostasis Dendritic Cell Chemotaxis Regulation Of Body Fluid Levels Wound Healing Chemotaxis Lymphocyte Chemotaxis Secretion Endocytosis T Cell Migration Cellular Copper Ion Homeostasis Hepatocyte Apoptotic Process Cell Activation Cellular Homeostasis Response To Wounding Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Muscle Contraction Phosphatidylinositol-3-phosphate Biosynthetic Process Copper Ion Homeostasis Suckling Behavior	Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Fc-epsilon Receptor Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Phosphatidylinositol-mediated Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Immune Response Immune Response-regulating Signaling Pathway Positive Regulation Of Signal Transduction Response To Organic Substance Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Leukocyte Migration Regulation Of Intracellular Signal Transduction Innate Immune Response Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of MAPK Cascade Positive Regulation Of Kinase Activity Immune Response Defense Response Regulation Of Signal Transduction Positive Regulation Of Transferase Activity Response To External Stimulus Positive Regulation Of Metabolic Process Cellular Response To Hormone Stimulus Cell Migration Wound Healing Regulation Of Catalytic Activity Chemotaxis Positive Regulation Of Phosphorylation Cell Motility Regulation Of Signaling Positive Regulation Of MAPK Cascade Positive Regulation Of Cellular Metabolic Process Insulin Receptor Signaling Pathway Signal Transduction Regulation Of Phosphorylation Response To Wounding Regulation Of MAP Kinase Activity
Tagcloud ?		adipoq akt1 correcting dfs ethnicity fdr germline igf1 ins irs1 lep lepr leprot modifiers mtor p13k pi3 pik3ca poorer recessive replicate rs1063539 rs11585329 rs1520220 rs2519757 rs2677760 snps tagging tsc1	422a akt3 circuit differentially dysregulated effectors encode gleason grades kallikrein kallikreins klk14 klk15 klk2 klk3 klk4 micrornas microsatellite minisatellite mirna mirnas nucleotides prostate proteases pseudogene repeats share silico talk
Tagcloud (Difference) ?		adipoq akt1 correcting dfs ethnicity fdr germline igf1 ins irs1 lep lepr leprot modifiers mtor p13k pi3 pik3ca poorer recessive replicate rs1063539 rs11585329 rs1520220 rs2519757 rs2677760 snps tagging tsc1	422a akt3 circuit differentially dysregulated effectors encode gleason grades kallikrein kallikreins klk14 klk15 klk2 klk3 klk4 micrornas microsatellite minisatellite mirna mirnas nucleotides prostate proteases pseudogene repeats share silico talk
Tagcloud (Intersection) ?