PIK3R5 and SDHB

Number of citations of the paper that reports this interaction (PMID 18624398)
4

Data Source:
BioGRID (two hybrid)

		PIK3R5	SDHB
Gene Name		phosphoinositide-3-kinase, regulatory subunit 5	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Phosphatidylinositol 3-kinase Complex, Class IB Membrane	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex II Extracellular Vesicular Exosome
	Molecular Function	G-protein Beta/gamma-subunit Complex Binding 1-phosphatidylinositol-3-kinase Regulator Activity	Protein Binding Succinate Dehydrogenase (ubiquinone) Activity Electron Carrier Activity Metal Ion Binding Ubiquinone Binding 2 Iron, 2 Sulfur Cluster Binding 3 Iron, 4 Sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process G-protein Coupled Receptor Signaling Pathway Blood Coagulation Phosphatidylinositol 3-kinase Signaling Platelet Activation Positive Regulation Of MAP Kinase Activity Regulation Of Phosphatidylinositol 3-kinase Activity Small Molecule Metabolic Process Positive Regulation Of Protein Kinase B Signaling	Tricarboxylic Acid Cycle Succinate Metabolic Process Aerobic Respiration Respiratory Electron Transport Chain Cellular Metabolic Process Small Molecule Metabolic Process
Pathways		Synthesis of PIPs at the plasma membrane Signaling by GPCR GPCR downstream signaling Metabolism of lipids and lipoproteins G-protein beta:gamma signalling G beta:gamma signalling through PI3Kgamma GPVI-mediated activation cascade Phospholipid metabolism Platelet activation, signaling and aggregation PI Metabolism	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport Citric acid cycle (TCA cycle)
Drugs
Diseases
GWAS			Height ( 20189936)
Protein-Protein Interactions		3 interactors: APP PIK3CG SDHB	5 interactors: ABCA1 GEM PIK3R5 SPRY2 XRN1
Entrez ID		23533	6390
HPRD ID		11433	01707
Ensembl ID		ENSG00000141506	ENSG00000117118
Uniprot IDs		J3KSW1 L7RT34 Q8WYR1	P21912
PDB IDs
Enriched GO Terms of Interacting Partners?		Platelet Activation Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Natural Killer Cell Chemotaxis Cellular Calcium Ion Homeostasis Negative Regulation Of Triglyceride Catabolic Process Neutrophil Extravasation Calcium Ion Homeostasis Collateral Sprouting Axon Midline Choice Point Recognition Respiratory Burst Involved In Defense Response Negative Regulation Of Cardiac Muscle Contraction Exocytosis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Cellular Metal Ion Homeostasis Negative Regulation Of Striated Muscle Contraction Blood Coagulation Hemostasis Small Molecule Metabolic Process Secretory Granule Localization Cellular Cation Homeostasis Cellular Ion Homeostasis Neuron Remodeling T Cell Chemotaxis Metal Ion Homeostasis Succinate Metabolic Process Secretion By Cell Negative Regulation Of Fibroblast Apoptotic Process Cellular Chemical Homeostasis Respiratory Burst Ion Homeostasis Dendritic Cell Chemotaxis Regulation Of Body Fluid Levels Wound Healing Chemotaxis Lymphocyte Chemotaxis Secretion Endocytosis T Cell Migration Cellular Copper Ion Homeostasis Hepatocyte Apoptotic Process Cell Activation Cellular Homeostasis Response To Wounding Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Muscle Contraction Phosphatidylinositol-3-phosphate Biosynthetic Process Copper Ion Homeostasis Suckling Behavior	Positive Regulation Of Protein Kinase B Signaling Regulation Of Protein Kinase B Signaling Interleukin-1 Beta Secretion Apolipoprotein A-I-mediated Signaling Pathway Interleukin-1 Secretion Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Nuclear MRNA Surveillance Cell Surface Receptor Signaling Pathway Regulation Of MAP Kinase Activity Negative Regulation Of Cholesterol Storage Lung Growth High-density Lipoprotein Particle Assembly RNA Surveillance Establishment Of Organelle Localization Intracellular Cholesterol Transport Intracellular Sterol Transport Regulation Of Neurotrophin TRK Receptor Signaling Pathway Histone MRNA Catabolic Process Phospholipid Homeostasis Platelet Dense Granule Organization Regulation Of Phosphorus Metabolic Process RRNA Catabolic Process Phospholipid Efflux Phagocytosis, Engulfment Bud Elongation Involved In Lung Branching Response To Low-density Lipoprotein Particle Interleukin-1 Beta Production Organelle Localization Cellular Response To Cholesterol Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of MAPK Cascade Reverse Cholesterol Transport Response To Laminar Fluid Shear Stress Membrane Invagination Regulation Of Intracellular Signal Transduction Protein-lipid Complex Assembly Response To Lipoprotein Particle Positive Regulation Of Protein Kinase Activity Cellular Response To Sterol Positive Regulation Of Cholesterol Efflux Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Lipid Storage Positive Regulation Of Kinase Activity Negative Regulation Of Ras GTPase Activity Positive Regulation Of Cholesterol Transport Histone MRNA Metabolic Process Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cholesterol Efflux Phosphatidylinositol 3-kinase Signaling
Tagcloud ?		adipoq akt1 correcting dfs ethnicity fdr germline igf1 ins irs1 lep lepr leprot modifiers mtor p13k pi3 pik3ca poorer recessive replicate rs1063539 rs11585329 rs1520220 rs2519757 rs2677760 snps tagging tsc1	alters anatomical bacteremia bacterium colonization colonizing competitors divergent fitness frda fumc genitourinary gluconeogenesis glycolysis mirabilis niche nutritional occupying pentose pfka pgi polymicrobial proteus pyka requirements tca tpia uncomplicated uropathogenic
Tagcloud (Difference) ?		adipoq akt1 correcting dfs ethnicity fdr germline igf1 ins irs1 lep lepr leprot modifiers mtor p13k pi3 pik3ca poorer recessive replicate rs1063539 rs11585329 rs1520220 rs2519757 rs2677760 snps tagging tsc1	alters anatomical bacteremia bacterium colonization colonizing competitors divergent fitness frda fumc genitourinary gluconeogenesis glycolysis mirabilis niche nutritional occupying pentose pfka pgi polymicrobial proteus pyka requirements tca tpia uncomplicated uropathogenic
Tagcloud (Intersection) ?