PIK3R5

Gene Name		phosphoinositide-3-kinase, regulatory subunit 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Phosphatidylinositol 3-kinase Complex, Class IB Membrane
	Molecular Function	G-protein Beta/gamma-subunit Complex Binding 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process G-protein Coupled Receptor Signaling Pathway Blood Coagulation Phosphatidylinositol 3-kinase Signaling Platelet Activation Positive Regulation Of MAP Kinase Activity Regulation Of Phosphatidylinositol 3-kinase Activity Small Molecule Metabolic Process Positive Regulation Of Protein Kinase B Signaling
Pathways		Synthesis of PIPs at the plasma membrane Signaling by GPCR GPCR downstream signaling Metabolism of lipids and lipoproteins G-protein beta:gamma signalling G beta:gamma signalling through PI3Kgamma GPVI-mediated activation cascade Phospholipid metabolism Platelet activation, signaling and aggregation PI Metabolism
Drugs
Diseases
GWAS
Protein-protein Interactions		3 interactors: APP PIK3CG SDHB
Entrez ID		23533
HPRD ID		11433
Ensembl ID		ENSG00000141506
Uniprot IDs		J3KSW1 L7RT34 Q8WYR1
PDB IDs
Enriched GO Terms of Interacting Partners?		Platelet Activation Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Natural Killer Cell Chemotaxis Cellular Calcium Ion Homeostasis Negative Regulation Of Triglyceride Catabolic Process Neutrophil Extravasation Calcium Ion Homeostasis Collateral Sprouting Axon Midline Choice Point Recognition Respiratory Burst Involved In Defense Response Negative Regulation Of Cardiac Muscle Contraction Exocytosis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Cellular Metal Ion Homeostasis Negative Regulation Of Striated Muscle Contraction Blood Coagulation Hemostasis Small Molecule Metabolic Process Secretory Granule Localization Cellular Cation Homeostasis Cellular Ion Homeostasis Neuron Remodeling T Cell Chemotaxis Metal Ion Homeostasis Succinate Metabolic Process Secretion By Cell Negative Regulation Of Fibroblast Apoptotic Process Cellular Chemical Homeostasis Respiratory Burst Ion Homeostasis Dendritic Cell Chemotaxis Regulation Of Body Fluid Levels Wound Healing Chemotaxis Lymphocyte Chemotaxis Secretion Endocytosis T Cell Migration Cellular Copper Ion Homeostasis Hepatocyte Apoptotic Process Cell Activation Cellular Homeostasis Response To Wounding Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Muscle Contraction Phosphatidylinositol-3-phosphate Biosynthetic Process Copper Ion Homeostasis Suckling Behavior
Tagcloud ?		adipoq akt1 correcting dfs ethnicity fdr germline igf1 ins irs1 lep lepr leprot modifiers mtor p13k pi3 pik3ca poorer recessive replicate rs1063539 rs11585329 rs1520220 rs2519757 rs2677760 snps tagging tsc1