PDE1A and APOA1

Number of citations of the paper that reports this interaction (PMID 11991719)
11

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PDE1A	APOA1
Gene Name		phosphodiesterase 1A, calmodulin-dependent	apolipoprotein A-I
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Neuronal Cell Body	Extracellular Region Extracellular Space Nucleus Early Endosome Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Cell Surface Endocytic Vesicle Cytoplasmic Vesicle Vesicle Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Discoidal High-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Secretory Granule Lumen Chylomicron Extracellular Vesicular Exosome Endocytic Vesicle Lumen Blood Microparticle
	Molecular Function	3',5'-cyclic-AMP Phosphodiesterase Activity Calmodulin-dependent Cyclic-nucleotide Phosphodiesterase Activity Calmodulin Binding CGMP Binding Metal Ion Binding Calcium- And Calmodulin-regulated 3',5'-cyclic-GMP Phosphodiesterase Activity	Beta-amyloid Binding Protein Binding Phospholipid Binding Phospholipid Transporter Activity High-density Lipoprotein Particle Binding Cholesterol Binding Cholesterol Transporter Activity Enzyme Binding Phosphatidylcholine Binding Apolipoprotein Receptor Binding Apolipoprotein A-I Receptor Binding Identical Protein Binding Chemorepellent Activity Lipase Inhibitor Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity High-density Lipoprotein Particle Receptor Binding
	Biological Process	CAMP Catabolic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Smooth Muscle Cell Apoptotic Process Innate Immune Response CGMP Catabolic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Smooth Muscle Cell Proliferation	Retinoid Metabolic Process Regulation Of Protein Phosphorylation Endothelial Cell Proliferation Platelet Degranulation Negative Regulation Of Cytokine Secretion Involved In Immune Response Phosphatidylcholine Biosynthetic Process Cholesterol Biosynthetic Process Receptor-mediated Endocytosis Transforming Growth Factor Beta Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Response To Nutrient Blood Coagulation Phototransduction, Visible Light Cholesterol Metabolic Process Glucocorticoid Metabolic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cholesterol Esterification Positive Regulation Of Triglyceride Catabolic Process Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Peripheral Nervous System Axon Regeneration Protein Oxidation Peptidyl-methionine Modification Lipid Storage Platelet Activation Regulation Of Intestinal Cholesterol Absorption Cholesterol Transport Adrenal Gland Development Organ Regeneration Neuron Projection Regeneration Regulation Of Cdc42 Protein Signal Transduction Cholesterol Efflux Phospholipid Efflux Negative Regulation Of Heterotypic Cell-cell Adhesion High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly High-density Lipoprotein Particle Clearance Positive Regulation Of Rho Protein Signal Transduction Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Response To Drug Cholesterol Homeostasis Blood Vessel Endothelial Cell Migration Response To Estrogen Reverse Cholesterol Transport Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Interleukin-1 Beta Secretion Negative Regulation Of Inflammatory Response Protein Stabilization Negative Chemotaxis Positive Regulation Of Lipoprotein Lipase Activity Positive Regulation Of Hydrolase Activity Positive Regulation Of Transferase Activity Positive Regulation Of Stress Fiber Assembly Transmembrane Transport Phospholipid Homeostasis Negative Regulation Of Lipase Activity Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Response To Cytokine Stimulus Triglyceride Homeostasis ERK1 And ERK2 Cascade Cholesterol Import Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Ca-dependent events Signaling by GPCR CaM pathway Signaling by FGFR in disease Phospholipase C-mediated cascade G alpha (s) signalling events Cam-PDE 1 activation cGMP effects Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling DAG and IP3 signaling DAP12 signaling CaM pathway Downstream signaling of activated FGFR Nitric oxide stimulates guanylate cyclase Innate Immune System Signaling by PDGF Calmodulin induced events DAP12 interactions Signalling by NGF PLC beta mediated events Opioid Signalling Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Cam-PDE 1 activation Signaling by EGFR GPCR downstream signaling Platelet homeostasis Downstream signal transduction Calmodulin induced events PLC-gamma1 signalling Signaling by EGFR in Cancer	Lipoprotein metabolism PPARA activates gene expression Metabolism of lipids and lipoproteins ABC-family proteins mediated transport Chylomicron-mediated lipid transport Platelet degranulation Amyloids Response to elevated platelet cytosolic Ca2+ Scavenging by Class A Receptors Retinoid metabolism and transport Fatty acid, triacylglycerol, and ketone body metabolism Lipid digestion, mobilization, and transport Diseases associated with visual transduction HDL-mediated lipid transport Scavenging of heme from plasma Visual phototransduction Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Platelet activation, signaling and aggregation Scavenging by Class B Receptors ABCA transporters in lipid homeostasis
Drugs
Diseases
GWAS			Cholesterol, total ( 19060911 20686565) Coronary heart disease ( 21378990) HDL cholesterol ( 20864672 19060906 20686565) Hematological and biochemical traits ( 20139978) Hypertriglyceridemia ( 23505323) LDL cholesterol ( 18179892 20864672 19060911 20686565) Lipid metabolism phenotypes ( 22286219) Metabolite levels ( 22916037) Triglycerides ( 19074352 21909109 18193043 18193044 18193046 20864672 19060906 19060911 20139978 20686565)
Protein-Protein Interactions		3 interactors: APOA1 APP CALM1	35 interactors: ABCA1 ABCA13 AKT2 APOA1BP APOA2 APOB APOC1 APOF APOL1 APP ATP5B CETP CFHR1 CLEC4G CMTM5 FBLN1 GPLD1 HPR JAK3 LBP LCAT MAP7D1 MAPK6 PCMT1 PDE1A PLTP PON1 SAA2 SCARB1 SPP1 TNFRSF10C TOMM20 TTR VKORC1 ZNRD1
Entrez ID		5136	335
HPRD ID		01387	02517
Ensembl ID		ENSG00000115252	ENSG00000118137
Uniprot IDs		B7Z226 B7Z7A2 P54750 Q9Y633	P02647
PDB IDs		1LXQ	1AV1 1GW3 1GW4 1ODP 1ODQ 1ODR 2A01 3J00 3K2S 3R2P
Enriched GO Terms of Interacting Partners?		Platelet Degranulation Platelet Activation Response To Light Stimulus Exocytosis Alcohol Metabolic Process Blood Coagulation Hemostasis Response To Radiation Regulation Of Cellular Ketone Metabolic Process Secretion By Cell Regulation Of Body Fluid Levels Wound Healing Secretion Cell Activation Response To Wounding Phototransduction, Visible Light Positive Regulation Of Lipase Activity Detection Of Visible Light Phototransduction Detection Of Light Stimulus Cholesterol Metabolic Process Positive Regulation Of Hydrolase Activity Sterol Metabolic Process Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Negative Regulation Of Cell Adhesion Molecule Production Detection Of Abiotic Stimulus Regulation Of Phosphorylation Vesicle-mediated Transport Synaptic Growth At Neuromuscular Junction Negative Regulation Of Interleukin-1 Beta Secretion Regulation Of Phosphorus Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Biosynthetic Process Steroid Metabolic Process Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Cholesterol Import Collateral Sprouting In Absence Of Injury Negative Regulation Of Interleukin-1 Secretion Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Response To External Stimulus Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cellular Protein Metabolic Process Establishment Of Localization In Cell Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction High-density Lipoprotein Particle Clearance Protein Oxidation	Cholesterol Metabolic Process Alcohol Metabolic Process Sterol Metabolic Process Cholesterol Transport Sterol Transport Lipid Transport Lipid Localization Steroid Metabolic Process Cholesterol Efflux Plasma Lipoprotein Particle Remodeling Regulation Of Plasma Lipoprotein Particle Levels Reverse Cholesterol Transport High-density Lipoprotein Particle Remodeling Small Molecule Metabolic Process Lipid Metabolic Process Lipoprotein Metabolic Process Cholesterol Homeostasis Sterol Homeostasis Regulation Of Cholesterol Transport Regulation Of Lipid Transport Protein-lipid Complex Assembly Lipid Homeostasis Phosphatidylcholine Metabolic Process Regulation Of Lipid Catabolic Process Glycerolipid Metabolic Process Plasma Lipoprotein Particle Clearance Phospholipid Transport Triglyceride Metabolic Process Neutral Lipid Metabolic Process Triglyceride-rich Lipoprotein Particle Remodeling Cellular Lipid Metabolic Process Phospholipid Efflux Low-density Lipoprotein Particle Remodeling Cellular Biogenic Amine Metabolic Process Transport Amine Metabolic Process Lipopolysaccharide Transport Endocytosis Regulation Of Lipid Metabolic Process Regulation Of Cholesterol Efflux Negative Regulation Of Lipid Transport Negative Regulation Of Lipid Catabolic Process Locomotion Regulation Of Phosphatidylcholine Catabolic Process Response To Lipid Chemical Homeostasis High-density Lipoprotein Particle Clearance Cell Motility Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Lipid Biosynthetic Process
Tagcloud ?		calmodulin calponin cgmp contractile culturing cyclic cytoplasmic dedifferentiated gels hydrolyzing medial migrate myosin neointima neointimal nucleotides opposite p27kip1 pdes phosphodiesterases proliferate redifferentiated restenosis sm subcultured synthetic vsmc vsmcs	admission atherosclerosis believed concentration consequence controls explain explanation explicable fifth genotypes hdl immediately infarction mi microg min ml myocardial nmol occured paraoxonase pon1 reside risen subfraction subgroups thrombolytic variation
Tagcloud (Difference) ?		calmodulin calponin cgmp contractile culturing cyclic cytoplasmic dedifferentiated gels hydrolyzing medial migrate myosin neointima neointimal nucleotides opposite p27kip1 pdes phosphodiesterases proliferate redifferentiated restenosis sm subcultured synthetic vsmc vsmcs	admission atherosclerosis believed concentration consequence controls explain explanation explicable fifth genotypes hdl immediately infarction mi microg min ml myocardial nmol occured paraoxonase pon1 reside risen subfraction subgroups thrombolytic variation
Tagcloud (Intersection) ?