PDE1A

Description		phosphodiesterase 1A
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Neuronal Cell Body
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Calmodulin-activated Dual Specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding Calmodulin Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity Calmodulin-activated 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Signal Transduction Regulation Of Smooth Muscle Cell Apoptotic Process CGMP Catabolic Process Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of CAMP/PKA Signal Transduction
Pathways		Cam-PDE 1 activation cGMP effects G alpha (s) signalling events
Drugs		Caffeine Nicardipine Felodipine Bepridil Trapidil
Diseases
GWAS		Alzheimer's disease in APOE e4+ carriers ( 25778476) Appendicular lean mass ( 33097823) Blood urea nitrogen levels ( 31152163) Diastolic blood pressure ( 30487518 28135244 27841878) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Estimated glomerular filtration rate ( 31152163 31451708) Intelligence (MTAG) ( 29326435) joint destruction in rheumatoid arthritis (rapid vs slow) ( 33585033) Mean arterial pressure ( 30487518) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Myocardial infarction ( 33532862) Night sleep phenotypes ( 27126917) Pulmonary arterial hypertension ( 29088834) Pulse pressure ( 30578418) Response to platinum-based chemotherapy (carboplatin) ( 21844884) Urate levels ( 31578528)
Interacting Genes		3 interacting genes: APOA1 APP CALM1
Entrez ID		5136
HPRD ID		01387
Ensembl ID		ENSG00000115252
Uniprot IDs		B7Z226 B7Z3A7 B7Z7A2 P54750 Q9Y633
PDB IDs
Enriched GO Terms of Interacting Partners?		High-density Lipoprotein Particle Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Lipoprotein Metabolic Process Cellular Response To Amyloid-beta Response To Amyloid-beta Regulation Of System Process Regulation Of Interleukin-1 Production G Protein-coupled Receptor Signaling Pathway Receptor Ligand Activity Intracellular Signaling Cassette Regulation Of Interleukin-1 Beta Production Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Calcium-mediated Signaling Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Synaptic Transmission Positive Regulation Of Endocytosis Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Supramolecular Fiber Organization Acetylcholine Receptor Activator Activity Calcium-mediated Signaling Lipoprotein Particle Positive Regulation Of Protein Import Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Peptidyl-methionine Modification High-density Lipoprotein Particle Receptor Binding PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Synaptic Plasticity Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Calcium Ion Transport Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Early Endosome Apolipoprotein A-I Receptor Binding Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Regulation Of Transport Phosphatidylcholine-sterol O-acyltransferase Activator Activity Regulation Of Small Molecule Metabolic Process Lipoprotein Biosynthetic Process
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