PDE1A

Gene Name		phosphodiesterase 1A, calmodulin-dependent
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Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Neuronal Cell Body
	Molecular Function	3',5'-cyclic-AMP Phosphodiesterase Activity Calmodulin-dependent Cyclic-nucleotide Phosphodiesterase Activity Calmodulin Binding CGMP Binding Metal Ion Binding Calcium- And Calmodulin-regulated 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	CAMP Catabolic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Smooth Muscle Cell Apoptotic Process Innate Immune Response CGMP Catabolic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Smooth Muscle Cell Proliferation
Pathways		Ca-dependent events Signaling by GPCR CaM pathway Signaling by FGFR in disease Phospholipase C-mediated cascade G alpha (s) signalling events Cam-PDE 1 activation cGMP effects Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling DAG and IP3 signaling DAP12 signaling CaM pathway Downstream signaling of activated FGFR Nitric oxide stimulates guanylate cyclase Innate Immune System Signaling by PDGF Calmodulin induced events DAP12 interactions Signalling by NGF PLC beta mediated events Opioid Signalling Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Cam-PDE 1 activation Signaling by EGFR GPCR downstream signaling Platelet homeostasis Downstream signal transduction Calmodulin induced events PLC-gamma1 signalling Signaling by EGFR in Cancer
Drugs
Diseases
GWAS
Protein-protein Interactions		3 interactors: APOA1 APP CALM1
Entrez ID		5136
HPRD ID		01387
Ensembl ID		ENSG00000115252
Uniprot IDs		B7Z226 B7Z7A2 P54750 Q9Y633
PDB IDs		1LXQ
Enriched GO Terms of Interacting Partners?		Platelet Degranulation Platelet Activation Response To Light Stimulus Exocytosis Alcohol Metabolic Process Blood Coagulation Hemostasis Response To Radiation Regulation Of Cellular Ketone Metabolic Process Secretion By Cell Regulation Of Body Fluid Levels Wound Healing Secretion Cell Activation Response To Wounding Phototransduction, Visible Light Positive Regulation Of Lipase Activity Detection Of Visible Light Phototransduction Detection Of Light Stimulus Cholesterol Metabolic Process Positive Regulation Of Hydrolase Activity Sterol Metabolic Process Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Negative Regulation Of Cell Adhesion Molecule Production Detection Of Abiotic Stimulus Regulation Of Phosphorylation Vesicle-mediated Transport Synaptic Growth At Neuromuscular Junction Negative Regulation Of Interleukin-1 Beta Secretion Regulation Of Phosphorus Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Biosynthetic Process Steroid Metabolic Process Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Cholesterol Import Collateral Sprouting In Absence Of Injury Negative Regulation Of Interleukin-1 Secretion Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Response To External Stimulus Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cellular Protein Metabolic Process Establishment Of Localization In Cell Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction High-density Lipoprotein Particle Clearance Protein Oxidation
Tagcloud ?		calmodulin calponin cgmp contractile culturing cyclic cytoplasmic dedifferentiated gels hydrolyzing medial migrate myosin neointima neointimal nucleotides opposite p27kip1 pdes phosphodiesterases proliferate redifferentiated restenosis sm subcultured synthetic vsmc vsmcs