CRNKL1 and BID

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		CRNKL1	BID
Description		crooked neck pre-mRNA splicing factor 1	BH3 interacting domain death agonist
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GO Annotations	Cellular Component	Prp19 Complex Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome Post-mRNA Release Spliceosomal Complex	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Mitochondrial Membrane
	Molecular Function	RNA Binding Protein Binding	Death Receptor Binding Protein Binding Ubiquitin Protein Ligase Binding Cysteine-type Endopeptidase Regulator Activity Involved In Apoptotic Process
	Biological Process	Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing RNA Splicing	Release Of Cytochrome C From Mitochondria Protein Targeting To Mitochondrion Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Apoptotic Mitochondrial Changes Positive Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Protein-containing Complex Assembly Cellular Response To Stress Intracellular Signal Transduction Regulation Of T Cell Proliferation Signal Transduction In Response To DNA Damage Mitochondrial ATP Synthesis Coupled Electron Transport Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of Epithelial Cell Proliferation Neuron Apoptotic Process Protein-containing Complex Assembly Establishment Of Protein Localization To Membrane Positive Regulation Of Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway Hepatocyte Apoptotic Process Mitochondrial Outer Membrane Permeabilization Supramolecular Fiber Organization Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Intracellular Signal Transduction Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Fibroblast Apoptotic Process Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		mRNA Splicing - Major Pathway	Activation of BAD and translocation to mitochondria Activation and oligomerization of BAK protein BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Activation, translocation and oligomerization of BAX TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Activation, myristolyation of BID and translocation to mitochondria
Drugs
Diseases
GWAS			Adult body size ( 32376654) Diisocyanate-induced asthma ( 25918132) Platelet count ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		7 interacting genes: BID CLK1 HSP90AA1 HSPB1 NRIP1 PPIL2 RNF10	36 interacting genes: AHCYL1 BAK1 BAX BCL2 BCL2A1 BCL2L1 BCL2L2 CAPN1 CAPN2 CASP1 CASP10 CASP2 CASP3 CASP8 CRMP1 CRNKL1 CSNK1A1 CSNK1E CSNK2A1 CSNK2A2 CSNK2B DDIT4L ERG28 FBN3 GAPDH GBP2 GZMB MCL1 PLEKHM1 RBM48 REL SETDB1 TLE1 TUBB2B YWHAB ZHX1
Entrez ID		51340	637
HPRD ID		09898	03590
Ensembl ID		ENSG00000101343	ENSG00000015475
Uniprot IDs		Q5JY65 Q9BZJ0	A8ASI8 B2ZP79 B3KT21 P55957
PDB IDs		5MQF 5XJC 5YZG 5Z56 5Z57 5Z58 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6ZYM 7A5P 7ABI 7DVQ 7QTT 7W59 7W5A 7W5B 8C6J 8CH6 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8RO2 9FMD	1ZY3 2BID 2KBW 2M5B 2M5I 4BD2 4QVE 4ZEQ 4ZIG 4ZII 5AJJ 5C3F 7M5A 7M5B 7P33 7QTW 8SM5
Enriched GO Terms of Interacting Partners?		Protein Folding Protein Refolding Establishment Of Protein Localization To Mitochondrion Protein Folding Chaperone Negative Regulation Of Protein Kinase C Signaling CTP Binding DATP Binding Ovarian Follicle Rupture Response To Unfolded Protein Response To Heat Cysteine-type Endopeptidase Regulator Activity Involved In Apoptotic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Unfolded Protein Binding Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Protein Kinase C Inhibitor Activity Rho GDP-dissociation Inhibitor Binding Histone Deacetylase Binding Response To Temperature Stimulus Cellular Localization Regulation Of Protein Kinase C Signaling Sperm Mitochondrial Sheath Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane	Bcl-2 Family Protein Complex Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Release Of Cytochrome C From Mitochondria Apoptotic Process Cell Death Programmed Cell Death Channel Activity Extrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Execution Phase Of Apoptosis Apoptotic Mitochondrial Changes Intrinsic Apoptotic Signaling Pathway BH3 Domain Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Protein Kinase CK2 Complex Mitochondrial Outer Membrane Cysteine-type Peptidase Activity Regulation Of Apoptotic Process Protein Maturation Regulation Of Programmed Cell Death Identical Protein Binding Leukocyte Apoptotic Process DNA Damage Response Regulation Of Neuron Apoptotic Process Mitochondrial Fusion Negative Regulation Of Anoikis Regulation Of Autophagy Signal Transduction Programmed Cell Death Involved In Cell Development Response To Cytokine Response To Peptide Negative Regulation Of Programmed Cell Death Regulation Of Anoikis Cysteine-type Endopeptidase Activity Peptidase Activity B Cell Homeostasis Cytosol Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Pyroptotic Inflammatory Response Mitochondrion Organization Regulation Of Proteolysis Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Signaling Pathway Response To Stress B Cell Apoptotic Process Pyroptotic Inflammatory Response
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