CRNKL1 and BID

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		CRNKL1	BID
Gene Name		crooked neck pre-mRNA splicing factor 1	BH3 interacting domain death agonist
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Spliceosomal Complex Cytoplasm Nuclear Speck Catalytic Step 2 Spliceosome	Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Integral Component Of Mitochondrial Membrane Extracellular Vesicular Exosome
	Molecular Function	RNA Binding Protein Binding Poly(A) RNA Binding	Death Receptor Binding Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome	Release Of Cytochrome C From Mitochondria Protein Targeting To Mitochondrion Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Brain Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Apoptotic Mitochondrial Changes Response To Estradiol Positive Regulation Of Protein Oligomerization Positive Regulation Of Protein Homooligomerization Glial Cell Apoptotic Process Regulation Of Cell Proliferation Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Protein Homooligomerization Neuron Apoptotic Process Establishment Of Protein Localization To Membrane Positive Regulation Of Release Of Cytochrome C From Mitochondria Intrinsic Apoptotic Signaling Pathway Hepatocyte Apoptotic Process Mitochondrial Outer Membrane Permeabilization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			Activation of BAD and translocation to mitochondria Activation, translocation and oligomerization of BAX Activation, myristolyation of BID and translocation to mitochondria Programmed Cell Death Activation of BH3-only proteins Activation and oligomerization of BAK protein BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: BID HSP90AA1 PPIL2	36 interactors: AHCYL1 BAK1 BAX BCL2 BCL2A1 BCL2L1 BCL2L2 C14orf1 CAPN1 CAPN2 CASP1 CASP10 CASP2 CASP3 CASP8 CRMP1 CRNKL1 CSNK1A1 CSNK1E CSNK2A1 CSNK2A2 CSNK2B FBN3 GAPDH GBP2 GZMB MCL1 PLEKHM1 RBM48 REL RPA1 SETDB1 TLE1 TUBB2B YWHAB ZHX1
Entrez ID		51340	637
HPRD ID		09898	03590
Ensembl ID		ENSG00000101343	ENSG00000015475
Uniprot IDs		Q5JY65 Q69YP1 Q9BZJ0	A8ASI8 B2ZP79 B3KT21 P55957
PDB IDs			1ZY3 2BID 2KBW 2M5B 4BD2
Enriched GO Terms of Interacting Partners?		Protein Localization To Membrane Mitochondrial Membrane Organization Protein Targeting To Mitochondrion Protein Localization To Mitochondrion Membrane Organization Mitochondrial Transport Cellular Protein Localization Establishment Of Protein Localization To Membrane Protein Folding Protein Import Into Mitochondrial Outer Membrane Protein Localization Establishment Of Protein Localization To Organelle Mitochondrion Organization Glial Cell Apoptotic Process Protein Targeting Cellular Localization Positive Regulation Of Protein Homooligomerization Mitochondrial Outer Membrane Permeabilization Protein Localization To Organelle Chaperone-mediated Protein Complex Assembly Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Protein Oligomerization Hepatocyte Apoptotic Process Protein Refolding Cytoplasmic Transport Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Response To Stress Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Nitric Oxide Metabolic Process Regulation Of Protein Oligomerization Regulation Of Cellular Response To Heat Reactive Nitrogen Species Metabolic Process Release Of Cytochrome C From Mitochondria Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Intracellular Protein Transport Regulation Of Membrane Permeability Regulation Of Nitric-oxide Synthase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Protein Complex Assembly Intracellular Protein Transmembrane Transport Neuron Apoptotic Process Positive Regulation Of Mitochondrion Organization Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Cell Death Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Cell Death Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Mitochondrion Organization Positive Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Release Of Cytochrome C From Mitochondria Positive Regulation Of Cell Death Regulation Of Signal Transduction Apoptotic Mitochondrial Changes Regulation Of Mitochondrial Membrane Potential Protein Processing Regulation Of Signaling Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Negative Regulation Of Anoikis Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Neuron Apoptotic Process Regulation Of Anoikis Signal Transduction Regulation Of Cysteine-type Endopeptidase Activity Response To Stress Neuron Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Cell Death Signaling Regulation Of Intrinsic Apoptotic Signaling Pathway Intracellular Signal Transduction Cell Communication Response To Stimulus Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Neuron Death Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Activation Of Cysteine-type Endopeptidase Activity Regulation Of Membrane Permeability
Tagcloud ?		anatomical assumes bcc bccs binomial correction drivers exome genesis hot intermittent invex landscape lend melanomas mutational nebl passengers patched permutation pick ptch1 sccs sequenced spots stat5b stringent uniform uniquely	3n burns catheter caustic cd ceb ceftazidime contents corticosteroids cp created decreasing dexamethasone ensues esophageal esophagograms grouped histologic hydroxide hydroxyproline im indwelling infused massive pentoxifylline scatritial stricture tid wistar
Tagcloud (Difference) ?		anatomical assumes bcc bccs binomial correction drivers exome genesis hot intermittent invex landscape lend melanomas mutational nebl passengers patched permutation pick ptch1 sccs sequenced spots stat5b stringent uniform uniquely	3n burns catheter caustic cd ceb ceftazidime contents corticosteroids cp created decreasing dexamethasone ensues esophageal esophagograms grouped histologic hydroxide hydroxyproline im indwelling infused massive pentoxifylline scatritial stricture tid wistar
Tagcloud (Intersection) ?