DACT1 and GRSF1

Number of citations of the paper that reports this interaction (PubMedID 32645484)
0

Data Source:
BioGRID (two hybrid)

		DACT1	GRSF1
Description		dishevelled binding antagonist of beta catenin 1	G-rich RNA sequence binding factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Beta-catenin Destruction Complex Synapse	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Ribonucleoprotein Granule Mitochondrial Nucleoid Ribonucleoprotein Complex
	Molecular Function	Protein Kinase C Binding Protein Binding Beta-catenin Binding Histone Deacetylase Binding Protein Kinase A Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Delta-catenin Binding Transcription Regulator Inhibitor Activity	G-quadruplex RNA Binding Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Nervous System Development Wnt Signaling Pathway Neural Tube Development Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Regulation Of Protein Stability Positive Regulation Of Protein Catabolic Process Negative Regulation Of JNK Cascade Embryonic Hindgut Morphogenesis Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Nodal Signaling Pathway Negative Regulation Of Beta-catenin-TCF Complex Assembly Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Mitochondrial RNA Catabolic Process Positive Regulation Of Mitochondrial RNA Catabolic Process MRNA Processing TRNA Processing Anterior/posterior Pattern Specification Morphogenesis Of Embryonic Epithelium Regulation Of RNA Splicing
Pathways		Degradation of DVL	Viral mRNA Translation Mitochondrial RNA degradation
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Colorectal cancer or advanced adenoma ( 30510241) Dentate gyrus granule cell layer volume (corrected for total hippocampal volume) ( 30279459) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hippocampal subfield CA1 volume (corrected for total hippocampal volume) ( 30279459) Hippocampal tail volume (corrected for total hippocampal volume) ( 30279459) Language functional connectivity ( 34929384) Left–right brain asymmetry ( 33723403) Metabolite levels ( 23823483) Occipital lobe volume ( 31396565) Parietal lobe volume ( 31396565)	Type 2 diabetes ( 30718926)
Interacting Genes		7 interacting genes: APPL1 C7orf25 CSNK2B GRSF1 PPP1CC SH3GL2 TK1	55 interacting genes: AUP1 BTBD6 CNRIP1 COMMD1 CYC1 DACT1 EIF1B ERO1A FADS2 FNTA FYN GSE1 GTF2E2 HCFC2 HIVEP3 ISYNA1 MAP6 MIR1-2 MIR106B MIR18B MIR200B MIR200C MIR205 MIR25 MIR31 MIR451A MIR9-1 MIR9-2 MIR92A1 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F2 MIRLET7G MIRLET7I NEUROD2 NOP53 NUP153 NUP93 OGT PIN1 PPIA PRNP PSMD10 RAB3A RING1 SLC25A21-AS1 UBE3C VPS11 ZNF3
Entrez ID		51339	2926
HPRD ID		09709	07276
Ensembl ID		ENSG00000165617	ENSG00000132463
Uniprot IDs		Q9NYF0	Q12849
PDB IDs			2LMI 4QU6 4QU7
Enriched GO Terms of Interacting Partners?		Adiponectin-activated Signaling Pathway	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Extracellular Vesicle MRNA 3'-UTR Binding Negative Regulation Of Translation MRNA Destabilization Negative Regulation Of Protein Metabolic Process RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Motility Negative Regulation Of Signal Transduction Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Locomotion Negative Regulation Of Interleukin-6-mediated Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Translation Negative Regulation Of Cell Migration Regulation Of MRNA Stability Positive Regulation Of Catabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of RNA Stability Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Angiogenesis Regulation Of MRNA Metabolic Process Regulation Of Vasculature Development
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