UBAP1 and PTPN23

Number of citations of the paper that reports this interaction (PubMedID 34761192)
84

Data Source:
BioGRID (two hybrid, affinity chromatography technology, pull down, two hybrid, x-ray crystallography, unspecified method, proximity labelling technology)

		UBAP1	PTPN23
Description		ubiquitin associated protein 1	protein tyrosine phosphatase non-receptor type 23
Image
GO Annotations	Cellular Component	ESCRT I Complex Cytoplasm Endosome Cytosol Plasma Membrane Endosome Membrane	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Cytoskeleton Cilium Nuclear Body Cytoplasmic Vesicle Centriolar Satellite Ciliary Basal Body Cell Projection Extracellular Exosome
	Molecular Function	Protein Binding Ubiquitin Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Protein Kinase Binding
	Biological Process	Protein Transport Multivesicular Body Assembly Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Fission	Negative Regulation Of Epithelial Cell Migration Protein Transport Cell Projection Organization Endocytic Recycling Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Early Endosome To Late Endosome Transport Cilium Assembly Positive Regulation Of Wnt Protein Secretion Positive Regulation Of Homophilic Cell Adhesion Positive Regulation Of Adherens Junction Organization Positive Regulation Of Early Endosome To Late Endosome Transport
Pathways		Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy	Interleukin-37 signaling
Drugs
Diseases
GWAS		Creatine kinase levels ( 29403010) Fruit consumption ( 32066663) Pulse pressure ( 30224653)	C-reactive protein levels ( 30388399) Refractive error ( 32231278) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		6 interacting genes: ITGA5 MAP3K1 PPIC PTPN23 UBC WWP2	12 interacting genes: ALG2 BICD1 CEP19 CEP55 CHMP4B DDX24 LRRK2 NOTCH2NLA PSMA3 TRIM27 UBAP1 WDR4
Entrez ID		51271	25930
HPRD ID		15597	05959
Ensembl ID		ENSG00000165006	ENSG00000076201
Uniprot IDs		A0A6G6AA68 Q9NZ09	B4DST5 Q9H3S7
PDB IDs		1WGN 4AE4 5LM1	3RAU 5CRU 5CRV 5LM1 5LM2 5MJY 5MJZ 5MK0 5MK1 5MK2 5MK3
Enriched GO Terms of Interacting Partners?		Symbiont Entry Into Host Cell Integrin Alpha5-beta1 Complex Modification-dependent Protein Catabolic Process Positive Regulation Of Homophilic Cell Adhesion Positive Regulation Of Adherens Junction Organization Biological Process Involved In Interaction With Host Alphav-beta3 Integrin-vitronectin Complex Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Wnt Protein Secretion Regulation Of Adherens Junction Organization Regulation Of Homophilic Cell Adhesion	Organelle Localization Microtubule Anchoring Microtubule Anchoring At Microtubule Organizing Center Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Organization Mitotic Cytokinetic Process Midbody Abscission Late Endosome To Vacuole Transport Vesicle-mediated Transport Intracellular Transport Endosomal Transport Membrane Organization Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway Metaphase Chromosome Alignment Cytokinetic Process Mitotic Metaphase Chromosome Alignment Vesicle Targeting, Trans-Golgi To Periciliary Membrane Compartment GDP-Man:Man(1)GlcNAc(2)-PP-Dol Alpha-1,3-mannosyltransferase Activity GDP-Man:Man(2)GlcNAc(2)-PP-Dol Alpha-1,6-mannosyltransferase Activity Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Negative Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Organelle Assembly Endosome TRNA Methyltransferase Activator Activity TRNA (m7G46) Methyltransferase Complex Mitotic Cytokinesis Chromosome Localization Alpha-1,3-mannosyltransferase Activity Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Beta-catenin Destruction Complex Binding Endosome Organization Establishment Of Protein Localization To Organelle Proteinase Activated Receptor Binding Negative Regulation Of Catabolic Process TRNA (guanine-N7)-methylation Cytoskeleton-dependent Cytokinesis Nucleus Organization Regulation Of Notch Signaling Pathway Positive Regulation Of Protein Autoubiquitination Response To Curcumin
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