PDZD11 and ATP7A

Number of citations of the paper that reports this interaction (PMID 16051599)
10

Data Source:
HPRD (in vivo, two hybrid)

		PDZD11	ATP7A
Gene Name		PDZ domain containing 11	ATPase, Cu++ transporting, alpha polypeptide
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytosol Cell-cell Junction Basolateral Plasma Membrane Synapse	Late Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Trans-Golgi Network Transport Vesicle Secretory Granule Brush Border Membrane Neuron Projection Neuronal Cell Body Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Protein C-terminus Binding	Copper-exporting ATPase Activity Copper Ion Transmembrane Transporter Activity Copper Ion Binding Protein Binding ATP Binding Superoxide Dismutase Copper Chaperone Activity Copper-dependent Protein Binding
	Biological Process	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Biotin Metabolic Process Exocytosis Neurotransmitter Secretion Asymmetric Protein Localization Pantothenate Metabolic Process Ion Transmembrane Transport Small Molecule Metabolic Process Maintenance Of Epithelial Cell Apical/basal Polarity Transmembrane Transport Protein Localization To Basolateral Plasma Membrane	Response To Reactive Oxygen Species Blood Vessel Development In Utero Embryonic Development Release Of Cytochrome C From Mitochondria Blood Vessel Remodeling Regulation Of Oxidative Phosphorylation Tryptophan Metabolic Process Tyrosine Metabolic Process Catecholamine Metabolic Process Copper Ion Transport Cellular Copper Ion Homeostasis Mitochondrion Organization Lactation Locomotory Behavior Response To Iron(III) Ion Response To Zinc Ion Detoxification Of Copper Ion Regulation Of Gene Expression Copper Ion Import Plasma Membrane Copper Ion Transport Peptidyl-lysine Modification Removal Of Superoxide Radicals Cerebellar Purkinje Cell Differentiation Pyramidal Neuron Development Central Nervous System Neuron Development Extracellular Matrix Organization Collagen Fibril Organization Hair Follicle Morphogenesis Ion Transmembrane Transport T-helper Cell Differentiation Epinephrine Metabolic Process Norepinephrine Metabolic Process Dopamine Metabolic Process Norepinephrine Biosynthetic Process Serotonin Metabolic Process Positive Regulation Of Catalytic Activity Pigmentation Negative Regulation Of Neuron Apoptotic Process Skin Development ATP Metabolic Process Elastic Fiber Assembly Lung Alveolus Development Negative Regulation Of Metalloenzyme Activity Positive Regulation Of Metalloenzyme Activity Neuron Projection Morphogenesis Dendrite Morphogenesis Cartilage Development Positive Regulation Of Oxidoreductase Activity Elastin Biosynthetic Process Transmembrane Transport Copper Ion Export
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG SLC-mediated transmembrane transport Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Ion transport by P-type ATPases Defective AMN causes hereditary megaloblastic anemia 1 Ion channel transport Transport of vitamins, nucleosides, and related molecules Defects in cobalamin (B12) metabolism Defective GIF causes intrinsic factor deficiency Vitamin B5 (pantothenate) metabolism Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Biotin transport and metabolism Defects in vitamin and cofactor metabolism	Ion transport by P-type ATPases Ion channel transport Detoxification of Reactive Oxygen Species
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: ATP2B2 ATP7A PLEKHA5 SIGMAR1	3 interactors: ATOX1 CP PDZD11
Entrez ID		51248	538
HPRD ID		06622	02054
Ensembl ID		ENSG00000120509	ENSG00000165240
Uniprot IDs		Q5EBL8	B4DRW0 Q04656 Q762B6
PDB IDs			1AW0 1KVI 1KVJ 1Q8L 1S6O 1S6U 1Y3J 1Y3K 1YJR 1YJT 1YJU 1YJV 2AW0 2G9O 2GA7 2K1R 2KIJ 2KMV 2KMX 3CJK
Enriched GO Terms of Interacting Partners?		Cerebellar Purkinje Cell Differentiation Serotonin Metabolic Process Cerebellar Purkinje Cell Layer Morphogenesis Cerebellar Cortex Formation Cell Differentiation In Hindbrain Cerebellar Purkinje Cell Layer Development Cerebellar Cortex Morphogenesis Cerebellum Morphogenesis Hindbrain Morphogenesis Lactation Cerebellar Cortex Development Regulation Of Oxidoreductase Activity Phenol-containing Compound Metabolic Process Body Fluid Secretion Cerebellum Development Elastin Biosynthetic Process Negative Regulation Of Citrulline Biosynthetic Process Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Arginine Catabolic Process Calcium Ion Import Across Plasma Membrane Plasma Membrane Copper Ion Transport Otolith Mineralization Negative Regulation Of The Force Of Heart Contraction Metencephalon Development Mammary Gland Development Hindbrain Development Calcium Ion Import Into Cell Copper Ion Export Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Cardiac Muscle Adaptation Elastin Metabolic Process Detoxification Of Copper Ion Negative Regulation Of Adrenergic Receptor Signaling Pathway Central Nervous System Neuron Differentiation Locomotory Behavior Regulation Of Neuron Apoptotic Process Response To Iron(III) Ion Epinephrine Metabolic Process Negative Regulation Of Nitric Oxide Mediated Signal Transduction Epidermis Development Negative Regulation Of Peptidyl-cysteine S-nitrosylation Positive Regulation Of CAMP-dependent Protein Kinase Activity Regulation Of Neuron Death Norepinephrine Biosynthetic Process Negative Regulation Of Metalloenzyme Activity Regulation Of Adrenergic Receptor Signaling Pathway Negative Regulation Of Calcineurin-NFAT Signaling Cascade Ribonucleotide Metabolic Process System Development Purine Nucleotide Metabolic Process	Copper Ion Transport Transition Metal Ion Homeostasis Intracellular Copper Ion Transport Transmembrane Transport Ion Transport Protein Localization To Basolateral Plasma Membrane Maintenance Of Epithelial Cell Apical/basal Polarity Maintenance Of Apical/basal Cell Polarity Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Copper Ion Transmembrane Transport Maintenance Of Cell Polarity Pantothenate Metabolic Process Biotin Metabolic Process Cellular Chemical Homeostasis Ion Homeostasis Cellular Copper Ion Homeostasis Cellular Homeostasis Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Copper Ion Homeostasis Asymmetric Protein Localization Establishment Or Maintenance Of Apical/basal Cell Polarity Metal Ion Transport Chemical Homeostasis Cation Transport Ion Transmembrane Transport Transport Homeostatic Process Cellular Iron Ion Homeostasis Water-soluble Vitamin Metabolic Process Neurotransmitter Secretion Vitamin Metabolic Process Iron Ion Homeostasis Regulation Of Neurotransmitter Levels Protein Localization To Plasma Membrane Establishment Of Localization In Cell Neurotransmitter Transport Establishment Or Maintenance Of Cell Polarity Response To Reactive Oxygen Species Plasma Membrane Organization Cellular Localization
Tagcloud ?			96h basolateral cd1 copper cuproenzyme deliver deprivation duodenum enterocytes grew iec influences irrespective kd ki67 menkes pcna perturbed proliferating pumping relate rodent shrna silenced slower transporting trigger unaltered unexpected
Tagcloud (Difference) ?			96h basolateral cd1 copper cuproenzyme deliver deprivation duodenum enterocytes grew iec influences irrespective kd ki67 menkes pcna perturbed proliferating pumping relate rodent shrna silenced slower transporting trigger unaltered unexpected
Tagcloud (Intersection) ?