PDZD11 and SIGMAR1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PDZD11	SIGMAR1
Gene Name		PDZ domain containing 11	sigma non-opioid intracellular receptor 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytosol Cell-cell Junction Basolateral Plasma Membrane Synapse	Nuclear Envelope Nuclear Inner Membrane Nuclear Outer Membrane Endoplasmic Reticulum Membrane Lipid Particle Integral Component Of Plasma Membrane Integral Component Of Membrane Cell Junction Growth Cone
	Molecular Function	Protein Binding Protein C-terminus Binding	Opioid Receptor Activity Drug Binding
	Biological Process	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Biotin Metabolic Process Exocytosis Neurotransmitter Secretion Asymmetric Protein Localization Pantothenate Metabolic Process Ion Transmembrane Transport Small Molecule Metabolic Process Maintenance Of Epithelial Cell Apical/basal Polarity Transmembrane Transport Protein Localization To Basolateral Plasma Membrane	Lipid Transport Nervous System Development Opioid Receptor Signaling Pathway Regulation Of Neuron Apoptotic Process
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG SLC-mediated transmembrane transport Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Ion transport by P-type ATPases Defective AMN causes hereditary megaloblastic anemia 1 Ion channel transport Transport of vitamins, nucleosides, and related molecules Defects in cobalamin (B12) metabolism Defective GIF causes intrinsic factor deficiency Vitamin B5 (pantothenate) metabolism Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Biotin transport and metabolism Defects in vitamin and cofactor metabolism
Drugs			Dextromethorphan Naltrexone
Diseases
GWAS
Protein-Protein Interactions		4 interactors: ATP2B2 ATP7A PLEKHA5 SIGMAR1	3 interactors: ANK2 ITPR3 PDZD11
Entrez ID		51248	10280
HPRD ID		06622	03580
Ensembl ID		ENSG00000120509	ENSG00000147955
Uniprot IDs		Q5EBL8	A2A3U5 B4DR71 Q99720
PDB IDs
Enriched GO Terms of Interacting Partners?		Cerebellar Purkinje Cell Differentiation Serotonin Metabolic Process Cerebellar Purkinje Cell Layer Morphogenesis Cerebellar Cortex Formation Cell Differentiation In Hindbrain Cerebellar Purkinje Cell Layer Development Cerebellar Cortex Morphogenesis Cerebellum Morphogenesis Hindbrain Morphogenesis Lactation Cerebellar Cortex Development Regulation Of Oxidoreductase Activity Phenol-containing Compound Metabolic Process Body Fluid Secretion Cerebellum Development Elastin Biosynthetic Process Negative Regulation Of Citrulline Biosynthetic Process Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Arginine Catabolic Process Calcium Ion Import Across Plasma Membrane Plasma Membrane Copper Ion Transport Otolith Mineralization Negative Regulation Of The Force Of Heart Contraction Metencephalon Development Mammary Gland Development Hindbrain Development Calcium Ion Import Into Cell Copper Ion Export Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Cardiac Muscle Adaptation Elastin Metabolic Process Detoxification Of Copper Ion Negative Regulation Of Adrenergic Receptor Signaling Pathway Central Nervous System Neuron Differentiation Locomotory Behavior Regulation Of Neuron Apoptotic Process Response To Iron(III) Ion Epinephrine Metabolic Process Negative Regulation Of Nitric Oxide Mediated Signal Transduction Epidermis Development Negative Regulation Of Peptidyl-cysteine S-nitrosylation Positive Regulation Of CAMP-dependent Protein Kinase Activity Regulation Of Neuron Death Norepinephrine Biosynthetic Process Negative Regulation Of Metalloenzyme Activity Regulation Of Adrenergic Receptor Signaling Pathway Negative Regulation Of Calcineurin-NFAT Signaling Cascade Ribonucleotide Metabolic Process System Development Purine Nucleotide Metabolic Process	Second-messenger-mediated Signaling Protein Localization To Plasma Membrane Protein Localization To T-tubule Protein Localization To M-band T-tubule Organization Plasma Membrane Organization Ion Transport Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Calcium Ion Transport Protein Localization To Basolateral Plasma Membrane Membrane Depolarization During SA Node Cell Action Potential Establishment Of Localization In Cell SA Node Cell Action Potential Maintenance Of Epithelial Cell Apical/basal Polarity Sensory Perception Of Sweet Taste Protein Localization To Membrane Maintenance Of Apical/basal Cell Polarity Sensory Perception Of Umami Taste Cellular Metal Ion Homeostasis Regulation Of Cardiac Muscle Cell Membrane Potential Endomembrane System Organization Atrial Cardiac Muscle Cell Action Potential SA Node Cell To Atrial Cardiac Muscle Cell Communication Atrial Cardiac Muscle Cell To AV Node Cell Communication Cellular Cation Homeostasis Cellular Ion Homeostasis Cellular Localization Response To Methylmercury Metal Ion Homeostasis Sarcoplasmic Reticulum Calcium Ion Transport Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Pantothenate Metabolic Process Maintenance Of Cell Polarity Biotin Metabolic Process Cellular Chemical Homeostasis Membrane Depolarization During Cardiac Muscle Cell Action Potential Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ion Homeostasis Cell-cell Signaling Involved In Cardiac Conduction Positive Regulation Of Potassium Ion Transmembrane Transport Paranodal Junction Assembly Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Inositol Phosphate-mediated Signaling Protein Localization To Cell Surface Ventricular Cardiac Muscle Cell Action Potential Cellular Homeostasis Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Atrial Septum Development Regulation Of Heart Rate By Cardiac Conduction
Tagcloud ?			became chaperones chronologically cytoplasm degrades epoxomicin exportin harboring hela huntingtin huntington inclusion inclusions insolubilized lc3 leptomycin machinery misfolded ni nis nucleus p62 participate polyglutamine proteasome shuttle sirna unchanged
Tagcloud (Difference) ?			became chaperones chronologically cytoplasm degrades epoxomicin exportin harboring hela huntingtin huntington inclusion inclusions insolubilized lc3 leptomycin machinery misfolded ni nis nucleus p62 participate polyglutamine proteasome shuttle sirna unchanged
Tagcloud (Intersection) ?