PDZD11 and ATP2B2

Number of citations of the paper that reports this interaction (PMID 12763866)
12

Data Source:
HPRD (two hybrid, in vitro)

		PDZD11	ATP2B2
Gene Name		PDZ domain containing 11	ATPase, Ca++ transporting, plasma membrane 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytosol Cell-cell Junction Basolateral Plasma Membrane Synapse	Cytoplasm Endoplasmic Reticulum Plasma Membrane Cilium Integral Component Of Membrane Apical Plasma Membrane Cell Junction Neuronal Cell Body Synapse Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein C-terminus Binding	Calcium-transporting ATPase Activity Calcium Ion Binding Protein Binding Calmodulin Binding ATP Binding Protein C-terminus Binding PDZ Domain Binding Calcium-dependent ATPase Activity Metal Ion Binding
	Biological Process	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Biotin Metabolic Process Exocytosis Neurotransmitter Secretion Asymmetric Protein Localization Pantothenate Metabolic Process Ion Transmembrane Transport Small Molecule Metabolic Process Maintenance Of Epithelial Cell Apical/basal Polarity Transmembrane Transport Protein Localization To Basolateral Plasma Membrane	Transport Calcium Ion Transport Organelle Organization Lactation Blood Coagulation Sensory Perception Of Sound Locomotory Behavior Regulation Of Cell Size Cerebellar Purkinje Cell Differentiation Cerebellar Granule Cell Differentiation Neuron Differentiation Ion Transmembrane Transport Locomotion Serotonin Metabolic Process Otolith Mineralization CGMP Metabolic Process Regulation Of Synaptic Plasticity Synapse Organization Neuromuscular Process Controlling Balance Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Cytosolic Calcium Ion Homeostasis Positive Regulation Of Calcium Ion Transport Transmembrane Transport Auditory Receptor Cell Stereocilium Organization Calcium Ion Transmembrane Transport Cochlea Development
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG SLC-mediated transmembrane transport Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Ion transport by P-type ATPases Defective AMN causes hereditary megaloblastic anemia 1 Ion channel transport Transport of vitamins, nucleosides, and related molecules Defects in cobalamin (B12) metabolism Defective GIF causes intrinsic factor deficiency Vitamin B5 (pantothenate) metabolism Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Biotin transport and metabolism Defects in vitamin and cofactor metabolism	Ion transport by P-type ATPases Ion channel transport Platelet homeostasis Reduction of cytosolic Ca++ levels Platelet calcium homeostasis
Drugs
Diseases
GWAS			Metabolite levels ( 19043545)
Protein-Protein Interactions		4 interactors: ATP2B2 ATP7A PLEKHA5 SIGMAR1	8 interactors: DLG1 DLG2 DLG4 ERBB2IP PDZD11 PRKCA SLC9A3R2 SNTA1
Entrez ID		51248	491
HPRD ID		06622	00160
Ensembl ID		ENSG00000120509	ENSG00000157087
Uniprot IDs		Q5EBL8	Q01814 Q4J699 Q4LE63
PDB IDs
Enriched GO Terms of Interacting Partners?		Cerebellar Purkinje Cell Differentiation Serotonin Metabolic Process Cerebellar Purkinje Cell Layer Morphogenesis Cerebellar Cortex Formation Cell Differentiation In Hindbrain Cerebellar Purkinje Cell Layer Development Cerebellar Cortex Morphogenesis Cerebellum Morphogenesis Hindbrain Morphogenesis Lactation Cerebellar Cortex Development Regulation Of Oxidoreductase Activity Phenol-containing Compound Metabolic Process Body Fluid Secretion Cerebellum Development Elastin Biosynthetic Process Negative Regulation Of Citrulline Biosynthetic Process Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Arginine Catabolic Process Calcium Ion Import Across Plasma Membrane Plasma Membrane Copper Ion Transport Otolith Mineralization Negative Regulation Of The Force Of Heart Contraction Metencephalon Development Mammary Gland Development Hindbrain Development Calcium Ion Import Into Cell Copper Ion Export Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Cardiac Muscle Adaptation Elastin Metabolic Process Detoxification Of Copper Ion Negative Regulation Of Adrenergic Receptor Signaling Pathway Central Nervous System Neuron Differentiation Locomotory Behavior Regulation Of Neuron Apoptotic Process Response To Iron(III) Ion Epinephrine Metabolic Process Negative Regulation Of Nitric Oxide Mediated Signal Transduction Epidermis Development Negative Regulation Of Peptidyl-cysteine S-nitrosylation Positive Regulation Of CAMP-dependent Protein Kinase Activity Regulation Of Neuron Death Norepinephrine Biosynthetic Process Negative Regulation Of Metalloenzyme Activity Regulation Of Adrenergic Receptor Signaling Pathway Negative Regulation Of Calcineurin-NFAT Signaling Cascade Ribonucleotide Metabolic Process System Development Purine Nucleotide Metabolic Process	Establishment Or Maintenance Of Apical/basal Cell Polarity Receptor Localization To Synapse Protein Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Cell Polarity Receptor Clustering Nucleotide Phosphorylation Maintenance Of Apical/basal Cell Polarity Membrane Organization Protein Localization To Membrane Cell-cell Signaling Maintenance Of Cell Polarity Synaptic Transmission Cellular Protein Localization Cortical Actin Cytoskeleton Organization Asymmetric Protein Localization Cortical Cytoskeleton Organization Regulation Of Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Protein Localization Regulation Of Sodium Ion Transport Negative Regulation Of Intracellular Signal Transduction Regulation Of Ion Transmembrane Transport Endomembrane System Organization Positive Regulation Of Dense Core Granule Biogenesis Regulation Of Vasoconstriction By Circulating Norepinephrine Small Molecule Metabolic Process Cellular Localization Basal Protein Localization Histone H3-T6 Phosphorylation Cell-cell Junction Assembly Nucleotide Metabolic Process Chemotaxis Regulation Of Ion Transport Nucleobase-containing Small Molecule Metabolic Process Protein Localization To Plasma Membrane Regulation Of Muscle Contraction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Heart Contraction Synapse Organization Regulation Of Intracellular Signal Transduction Protein Localization To Basolateral Plasma Membrane T Cell Cytokine Production Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Behavior Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Grooming Behavior Hard Palate Development Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering
Tagcloud ?			ankrd2 arg autoprocessing bak calpain calpains capability cleavages controllers destabilizing eliminating favor glu glun2a grm1 ica512 igfbp2 lived mechanistically multitude nonprocessive oligomeric phe phosphatases pressures proteases rule underlies virtually
Tagcloud (Difference) ?			ankrd2 arg autoprocessing bak calpain calpains capability cleavages controllers destabilizing eliminating favor glu glun2a grm1 ica512 igfbp2 lived mechanistically multitude nonprocessive oligomeric phe phosphatases pressures proteases rule underlies virtually
Tagcloud (Intersection) ?