MYO15A and WHRN

Number of citations: 0 (PubMedID 15590698)
Data Source: HPRD (in vitro, in vivo)

		MYO15A	WHRN
Name		myosin XVA	whirlin
Structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Actin Cytoskeleton Membrane Myosin Complex Stereocilium Stereocilium Bundle Cell Projection Extracellular Exosome Actin-based Cell Projection	Photoreceptor Inner Segment Stereocilia Ankle Link Stereocilia Ankle Link Complex Cytoplasm Actin Filament Plasma Membrane Cilium Growth Cone Photoreceptor Connecting Cilium Stereocilium Stereocilium Bundle Stereocilium Tip Ciliary Basal Body Cell Projection Neuron Projection Neuronal Cell Body Synapse Periciliary Membrane Compartment USH2 Complex
	Molecular Function	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Calmodulin Binding ATP Binding Actin Filament Binding	Protein Binding Identical Protein Binding
	Biological Process	Endocytosis Actin Filament Organization Sensory Perception Of Sound Locomotory Behavior Response To Light Stimulus Inner Ear Morphogenesis	Retina Homeostasis Sensory Perception Of Sound Positive Regulation Of Gene Expression Cerebellar Purkinje Cell Layer Formation Establishment Of Protein Localization Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Sensory Perception Of Light Stimulus Establishment Of Localization In Cell Auditory Receptor Cell Stereocilium Organization Inner Ear Receptor Cell Differentiation Inner Ear Receptor Cell Stereocilium Organization Paranodal Junction Maintenance
Pathways		Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Diseases		Deafness, autosomal recessive	Deafness, autosomal recessive Usher syndrome (US)
GWAS		Basal cell carcinoma ( 33549134 ) Change in neurofilament light levels ( 31295725 ) Haemorrhoidal disease ( 33888516 ) Hip index ( 34021172 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Obesity-related traits ( 23251661 ) Red blood cell count ( 32888494 ) Schizophrenia ( 25056061 ) Serum folate levels ( 29953918 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	No GWAS studies recorded
Novel Interactors		None recorded	1 novel interactors: TTF1
Interacting Genes		4 interacting genes: EPS8 FASLG USP13 WHRN	17 interacting genes: BEND7 BMI1 CASK COL17A1 EFHC1 GOLGA2 GPSM2 HEMGN KEAP1 LRP4 LRRC4C MYO15A MYO7A PXN RPS6KA1 SPC24 TPRN
Entrez ID		51168	25861
HPRD ID		04049	09718
Ensembl ID		ENSG00000091536	ENSG00000095397
Uniprot IDs		Q9UKN7	B9EGE6 Q9P202
PDB IDs		6KZ1	1UEZ 1UF1 1UFX 6KZ1 7EP7
GO Terms Enriched among Interactors		Stereocilium Bundle Stereocilium Tip Stereocilium Positive Regulation Of Phospholipid Translocation Cytoplasmic Vesicle Lumen Retinal Cell Programmed Cell Death Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Growth Cone Protein K29-linked Deubiquitination Maintenance Of Unfolded Protein BAT3 Complex Binding Protein K6-linked Deubiquitination Cerebellar Purkinje Cell Layer Formation Stereocilia Ankle Link Paranodal Junction Maintenance Stereocilia Ankle Link Complex USH2 Complex Periciliary Membrane Compartment Inflammatory Cell Apoptotic Process Actin Polymerization-dependent Cell Motility Necroptotic Signaling Pathway Intracellular Chloride Ion Homeostasis NMDA Selective Glutamate Receptor Complex Behavioral Response To Ethanol Neuron Projection Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Cellular Response To Cytokine Stimulus Positive Regulation Of Phospholipid Transport Endosomal Lumen Acidification Necroptotic Process Positive Regulation Of Ruffle Assembly Actin Crosslink Formation Exit From Mitosis Chloride Ion Homeostasis Regulation Of Plasma Membrane Organization Death Receptor Binding Barbed-end Actin Filament Capping Proteasome Binding Positive Regulation Of ERAD Pathway Melanocyte Differentiation K48-linked Deubiquitinase Activity Auditory Receptor Cell Stereocilium Organization Retina Homeostasis Programmed Necrotic Cell Death Monoatomic Anion Homeostasis Pigment Cell Differentiation Cell-cell Junction Maintenance Programmed Cell Death Involved In Cell Development Inner Ear Receptor Cell Differentiation	Stereocilium Base Stereocilium Mitotic Spindle Organization Auditory Receptor Cell Stereocilium Organization