MYO15A

Name	myosin XVA
Structure
Interactors	4 interactors: EPS8 FASLG USP13 WHRN
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Actin Cytoskeleton Membrane Myosin Complex Stereocilium Stereocilium Bundle Cell Projection Extracellular Exosome Actin-based Cell Projection
	Molecular Function	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Calmodulin Binding ATP Binding Actin Filament Binding
	Biological Process	Endocytosis Actin Filament Organization Sensory Perception Of Sound Locomotory Behavior Response To Light Stimulus Inner Ear Morphogenesis
Pathways	Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Diseases	Deafness, autosomal recessive
GWAS	Basal cell carcinoma ( 33549134 ) Change in neurofilament light levels ( 31295725 ) Haemorrhoidal disease ( 33888516 ) Hip index ( 34021172 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Obesity-related traits ( 23251661 ) Red blood cell count ( 32888494 ) Schizophrenia ( 25056061 ) Serum folate levels ( 29953918 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Entrez ID	51168
HPRD ID	04049
Ensembl ID	ENSG00000091536
Uniprot IDs	Q9UKN7
PDB IDs	6KZ1
GO Terms Enriched among Interactors ?	Stereocilium Bundle Stereocilium Tip Stereocilium Positive Regulation Of Phospholipid Translocation Cytoplasmic Vesicle Lumen Retinal Cell Programmed Cell Death Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Growth Cone Protein K29-linked Deubiquitination Maintenance Of Unfolded Protein BAT3 Complex Binding Protein K6-linked Deubiquitination Cerebellar Purkinje Cell Layer Formation Stereocilia Ankle Link Paranodal Junction Maintenance Stereocilia Ankle Link Complex USH2 Complex Periciliary Membrane Compartment Inflammatory Cell Apoptotic Process Actin Polymerization-dependent Cell Motility Necroptotic Signaling Pathway Intracellular Chloride Ion Homeostasis NMDA Selective Glutamate Receptor Complex Behavioral Response To Ethanol Neuron Projection Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Cellular Response To Cytokine Stimulus Positive Regulation Of Phospholipid Transport Endosomal Lumen Acidification Necroptotic Process Positive Regulation Of Ruffle Assembly Actin Crosslink Formation Exit From Mitosis Chloride Ion Homeostasis Regulation Of Plasma Membrane Organization Death Receptor Binding Barbed-end Actin Filament Capping Proteasome Binding Positive Regulation Of ERAD Pathway Melanocyte Differentiation K48-linked Deubiquitinase Activity Auditory Receptor Cell Stereocilium Organization Retina Homeostasis Programmed Necrotic Cell Death Monoatomic Anion Homeostasis Pigment Cell Differentiation Cell-cell Junction Maintenance Programmed Cell Death Involved In Cell Development Inner Ear Receptor Cell Differentiation