MYO15A and USP13

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		MYO15A	USP13
Name		myosin XVA	ubiquitin specific peptidase 13
Structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Actin Cytoskeleton Membrane Myosin Complex Stereocilium Stereocilium Bundle Cell Projection Extracellular Exosome Actin-based Cell Projection	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Calmodulin Binding ATP Binding Actin Filament Binding	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding Ubiquitin-like Protein Ligase Binding Metal Ion Binding Protein-folding Chaperone Binding Proteasome Binding BAT3 Complex Binding K48-linked Deubiquitinase Activity
	Biological Process	Endocytosis Actin Filament Organization Sensory Perception Of Sound Locomotory Behavior Response To Light Stimulus Inner Ear Morphogenesis	Regulation Of DNA-templated Transcription Proteolysis Autophagy Cell Population Proliferation Regulation Of Autophagy Protein Deubiquitination Melanocyte Differentiation Regulation Of Protein Stability Protein K29-linked Deubiquitination Maintenance Of Unfolded Protein Protein K6-linked Deubiquitination Protein Stabilization Protein K63-linked Deubiquitination Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of ERAD Pathway
Pathways		Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Ub-specific processing proteases Regulation of PTEN stability and activity
Diseases		Deafness, autosomal recessive	None
GWAS		Basal cell carcinoma ( 33549134 ) Change in neurofilament light levels ( 31295725 ) Haemorrhoidal disease ( 33888516 ) Hip index ( 34021172 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Obesity-related traits ( 23251661 ) Red blood cell count ( 32888494 ) Schizophrenia ( 25056061 ) Serum folate levels ( 29953918 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	No GWAS studies recorded
Interacting Genes		4 interacting genes: EPS8 FASLG USP13 WHRN	25 interacting genes: AMFR ATG5 CCND1 CLK3 CSNK2A1 CTNNB1 DAZAP2 DVL1 DYRK1A FNBP1L FUNDC2 G3BP1 LAPTM5 MDC1 MRPL20 MYO15A SIAH2 SPRR2C TOPBP1 TRIM55 TRIM63 TWIST1 UBC UBL4A UIMC1
Entrez ID		51168	8975
HPRD ID		04049	04666
Ensembl ID		ENSG00000091536	ENSG00000058056
Uniprot IDs		Q9UKN7	A0A0A6YZ17 Q92995
PDB IDs		6KZ1	2L80 2LBC
GO Terms Enriched among Interactors		Stereocilium Bundle Stereocilium Tip Stereocilium Positive Regulation Of Phospholipid Translocation Cytoplasmic Vesicle Lumen Retinal Cell Programmed Cell Death Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Growth Cone Protein K29-linked Deubiquitination Maintenance Of Unfolded Protein BAT3 Complex Binding Protein K6-linked Deubiquitination Cerebellar Purkinje Cell Layer Formation Stereocilia Ankle Link Paranodal Junction Maintenance Stereocilia Ankle Link Complex USH2 Complex Periciliary Membrane Compartment Inflammatory Cell Apoptotic Process Actin Polymerization-dependent Cell Motility Necroptotic Signaling Pathway Intracellular Chloride Ion Homeostasis NMDA Selective Glutamate Receptor Complex Behavioral Response To Ethanol Neuron Projection Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Cellular Response To Cytokine Stimulus Positive Regulation Of Phospholipid Transport Endosomal Lumen Acidification Necroptotic Process Positive Regulation Of Ruffle Assembly Actin Crosslink Formation Exit From Mitosis Chloride Ion Homeostasis Regulation Of Plasma Membrane Organization Death Receptor Binding Barbed-end Actin Filament Capping Proteasome Binding Positive Regulation Of ERAD Pathway Melanocyte Differentiation K48-linked Deubiquitinase Activity Auditory Receptor Cell Stereocilium Organization Retina Homeostasis Programmed Necrotic Cell Death Monoatomic Anion Homeostasis Pigment Cell Differentiation Cell-cell Junction Maintenance Programmed Cell Death Involved In Cell Development Inner Ear Receptor Cell Differentiation	DNA Damage Checkpoint Signaling Protein Modification Process Wnt Signaling Pathway Protein Ubiquitination Mitotic DNA Integrity Checkpoint Signaling Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Signaling Negative Regulation Of Autophagic Cell Death Autophagy Protein Localization To Site Of Double-strand Break Protein Modification By Small Protein Conjugation Regulation Of Protein Ubiquitination Intracellular Signal Transduction Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle Protein Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Regulation Of Post-translational Protein Modification Chaperone-mediated Autophagy Positive Regulation Of Stress Granule Assembly Negative Regulation Of Signal Transduction By P53 Class Mediator Post-translational Protein Modification Response To Stress Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cell Cycle Process Identical Protein Binding Negative Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Double-strand Break Repair Via Nonhomologous End Joining Double-strand Break Repair Via Classical Nonhomologous End Joining Regulation Of Stress Granule Assembly Ubiquitin Protein Ligase Binding Regulation Of DNA Metabolic Process Genitalia Morphogenesis Regulation Of Wnt Signaling Pathway Cellular Response To Stress Negative Regulation Of Wnt Signaling Pathway Wnt Signalosome Cardiac Muscle Cell Apoptotic Process Catabolic Process Protein Serine/threonine Kinase Activator Activity Nucleus Aggrephagy Striated Muscle Cell Apoptotic Process Macromolecule Metabolic Process Regulation Of Cellular Response To Stress Protein-containing Complex Macromolecule Catabolic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Catabolic Process