PTPN22 and HMGCS2

		PTPN22	HMGCS2
Description		protein tyrosine phosphatase non-receptor type 22	3-hydroxy-3-methylglutaryl-CoA synthase 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoplasmic Side Of Plasma Membrane Perinuclear Region Of Cytoplasm	Mitochondrion Mitochondrial Matrix
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity SH3 Domain Binding Kinase Binding Ubiquitin Protein Ligase Binding	Hydroxymethylglutaryl-CoA Synthase Activity Transferase Activity Acyltransferase Activity Identical Protein Binding
	Biological Process	Immune System Process Lipid Metabolic Process Autophagy Negative Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression T Cell Differentiation Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Type II Interferon Production Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Phosphoanandamide Dephosphorylation Negative Regulation Of JUN Kinase Activity Regulation Of Innate Immune Response T Cell Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Muramyl Dipeptide Positive Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Protein K63-linked Ubiquitination Negative Regulation Of P38MAPK Cascade	Kidney Development Liver Development Acetyl-CoA Metabolic Process Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Midgut Development Response To Nutrient Steroid Metabolic Process Cholesterol Metabolic Process Isoprenoid Biosynthetic Process Response To Temperature Stimulus Response To Xenobiotic Stimulus Response To Bacterium Response To Metal Ion Farnesyl Diphosphate Biosynthetic Process, Mevalonate Pathway Sterol Biosynthetic Process Lung Development Response To Insulin Cellular Response To Insulin Stimulus Cellular Response To Hormone Stimulus Multicellular Organismal Response To Stress Response To Testosterone Response To Glucagon Response To Triglyceride Response To Monosaccharide Response To Prostaglandin F Response To Starvation Response To Peptide Hormone Response To Ethanol Ketone Body Biosynthetic Process Response To Glucocorticoid Response To CAMP Response To Growth Hormone Adipose Tissue Development Response To Fatty Acid Response To Linoleic Acid Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Fatty Acid
Pathways		Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse	PPARA activates gene expression Synthesis of Ketone Bodies Mitochondrial protein degradation
Drugs
Diseases		Type I diabetes mellitus	HMG-CoA synthase (HMGCS) deficiency
GWAS		Alopecia areata ( 25608926) Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757) Arthritis (juvenile idiopathic) ( 33106285) Autoimmune thyroid disease ( 32581359) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Autoimmune traits (pleiotropy) ( 30572963) Breast cancer ( 23535729) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 21102463 28067908 23128233) Giant cell arteritis ( 25817017) Granulocyte count ( 27863252) Graves' disease ( 22922229) Gut microbiota (bacterial taxa) ( 27694959) Hashimoto thyroiditis ( 22922229) Hodgkin's lymphoma ( 30194254) Hypothyroidism ( 22493691 27182965) Idiopathic inflammatory myopathy ( 26362759) IgM levels ( 28628107) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Late-onset myasthenia gravis ( 26562150) Latent autoimmune diabetes vs. type 2 diabetes ( 30254083) Lymphocyte count ( 27863252 32888494) Medication use (drugs used in diabetes) ( 31015401) Medication use (thyroid preparations) ( 31015401) Myasthenia gravis ( 23055271) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Obesity-related traits ( 23251661) Pediatric autoimmune diseases ( 26301688) Polymyositis ( 26362759) Rheumatoid arthritis ( 30423114 30572963 30891314 17554300 17804836 18794853 19503088 21156761 24449572 24390342 23143596) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Severe autoimmune type 2 diabetes ( 34737425) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 28714469 19838195 26502338 27399966) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Thyroid peroxidase antibody levels ( 24586183) Type 1 diabetes ( 21829393 17554260 17554300 17632545 25751624 19430480 30572963 18978792) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Vitiligo ( 27723757 20410501) White blood cell count ( 32888494 27863252)	Change in glucose in response to thiazide diuretic treatment in hypertension ( 29523524) Macular telangiectasia type 2 ( 33654266) Metabolite levels ( 23823483)
Interacting Genes		13 interacting genes: CBL CD247 CD3E CLK1 CRK CSK EGFR GRB2 LCK PRKCD SRPK2 VAV1 ZAP70	3 interacting genes: APP FBXO7 HSD17B10
Entrez ID		26191	3158
HPRD ID		06100	02580
Ensembl ID		ENSG00000134242	ENSG00000134240
Uniprot IDs		B4DZW8 F5H2S8 G3K0T4 Q9Y2R2	A0A140VJL2 P54868
PDB IDs		2P6X 2QCJ 2QCT 3BRH 3H2X 3OLR 3OMH 4J51 7AAM	2WYA
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade T Cell Costimulation Cell-cell Junction Non-membrane Spanning Protein Tyrosine Kinase Activity Immune Response-activating Signaling Pathway Protein Tyrosine Kinase Activity Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway Lymphocyte Activation Fc-gamma Receptor Signaling Pathway Immune System Process Leukocyte Activation Protein Tyrosine Kinase Binding T Cell Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cell Activation Positive Regulation Of Immune Response Regulation Of Immune Response Positive Regulation Of T Cell Activation Fc Receptor Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Immune System Process Positive Regulation Of Cell Adhesion T Cell Activation Protein Kinase Activity Regulation Of Cell-cell Adhesion Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion T Cell Receptor Complex Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Lymphocyte Activation Gamma-delta T Cell Activation Regulation Of Signal Transduction Immune Response Regulation Of Immune System Process Positive Regulation Of Signal Transduction Kinase Activity Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Protein Phosphatase Binding Regulation Of Cell Activation Gamma-delta T Cell Receptor Complex Ephrin Receptor Binding	Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Protein Tetramerization Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Type II Interferon Production Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Phosphoanandamide Dephosphorylation Regulation Of Non-canonical NF-kappaB Signal Transduction Leukocyte Activation Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of JNK Cascade Regulation Of Cell Activation Regulation Of Type II Interferon Production Endosome To Plasma Membrane Transport Vesicle Regulation Of Interleukin-6 Production Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Cell Activation Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity Brexanolone Metabolic Process Mitochondrial Ribonuclease P Complex Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing Mitochondrial TRNA Methylation Lewy Body Core Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Tumor Necrosis Factor Production Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Positive Regulation Of ERK1 And ERK2 Cascade
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