CHCHD2 and RNF144B

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		CHCHD2	RNF144B
Name		coiled-coil-helix-coiled-coil-helix domain containing 2	ring finger protein 144B
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Intermembrane Space	Ubiquitin Ligase Complex Cytoplasm Mitochondrion Cytosol Membrane Organelle Membrane Mitochondrial Membrane
	Molecular Function	Protein Binding Sequence-specific DNA Binding DNA-binding Transcription Factor Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Mitochondrion Organization Cellular Response To Oxidative Stress Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Response To Hypoxia Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Protein Ubiquitination Negative Regulation Of Apoptotic Process
Pathways		Mitochondrial protein import Mitochondrial protein degradation	Antigen processing: Ubiquitination & Proteasome degradation
GWAS		Macular telangiectasia type 2 ( 33654266 ) Metabolite levels ( 23823483 31628463 ) Plasma free amino acid levels ( 30659259 ) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259 )	Adult body size ( 32376654 ) Age at voice drop ( 27182965 ) Appendicular lean mass ( 33097823 ) Caudal middle frontal gyrus volume ( 31530798 ) Chronic periodontitis (mean interproximal clinical attachment level) ( 27601451 ) Chronotype ( 30696823 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189 ) Endometriosis ( 23472165 ) Facial morphology ( 31763980 ) General risk tolerance (MTAG) ( 30643258 ) Gut microbiota relative abundance (Dorea) ( 33208821 ) Pulse pressure ( 30224653 ) Thiopurine S-methyltransferase activity ( 27770449 ) Triglyceride levels ( 32203549 )
Interacting Genes		30 interacting genes: ADAMTSL4 ADRA2C CHCHD10 CRYBA1 CTAG1A CTAG1B CYSRT1 EHMT2 FBXO7 GOLGA2 IKZF3 INCA1 KRT31 KRT40 LHX4 MIF4GD OIP5 P4HB PBX4 PLEKHF2 REL RNF144B TCF4 TRAF2 TREX1 TRIM42 TRIM54 TSC1 USP54 ZMYND12	28 interacting genes: ANKS1A CDKN1A CHCHD2 CREB5 FOXH1 IL16 OTX1 PAN2 PAX5 PRKAB2 PROP1 PRR35 RIPPLY1 SGTA SGTB TRAF4 UBC UBE2I UBE2L3 UBE2L6 UBE2T UBE2U UBE2Z UBQLN1 USP15 USP2 VENTX ZIC1
Entrez ID		51142	255488
HPRD ID		09879	17126
Ensembl ID		ENSG00000106153	ENSG00000137393
Uniprot IDs		Q9Y6H1	Q7Z419
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Identical Protein Binding	Ubiquitin Conjugating Enzyme Activity Ubiquitin-like Protein Transferase Activity Nucleus Proteolysis Involved In Protein Catabolic Process Proteolysis TRC Complex Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Positive Regulation Of Metabolic Process Post-translational Protein Modification Positive Regulation Of Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Modification By Small Protein Conjugation Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of ERAD Pathway Pattern Specification Process Positive Regulation Of RNA Metabolic Process Protein Ubiquitination Cysteine-type Deubiquitinase Activity Regulation Of RNA Metabolic Process Regulation Of ERAD Pathway Catabolic Process Protein Binding Protein Modification Process Protein Targeting To ER Protein Polyubiquitination Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cyclin Binding Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Establishment Of Protein Localization To Endoplasmic Reticulum Diencephalon Morphogenesis SUMO Conjugating Enzyme Activity Negative Regulation Of Store-operated Calcium Channel Activity Protein Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Protein K11-linked Ubiquitination