CHCHD2 and CHCHD10

Number of citations of the paper that reports this interaction (PubMedID 27499296)
55

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		CHCHD2	CHCHD10
Description		coiled-coil-helix-coiled-coil-helix domain containing 2	coiled-coil-helix-coiled-coil-helix domain containing 10
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Intermembrane Space	Nucleus Mitochondrion Mitochondrial Intermembrane Space MICOS Complex
	Molecular Function	Protein Binding Sequence-specific DNA Binding DNA-binding Transcription Factor Binding	Molecular_function Protein Binding
	Biological Process	Mitochondrion Organization Cellular Response To Oxidative Stress Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Response To Hypoxia Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport	Mitochondrion Organization Mitochondrial Membrane Organization Inner Mitochondrial Membrane Organization Stabilization Of Membrane Potential Mitochondria-nucleus Signaling Pathway Maintenance Of Protein Location In Nucleus Maintenance Of Synapse Structure Positive Regulation Of Mitochondrial Transcription
Pathways		Mitochondrial protein import Mitochondrial protein degradation	Mitochondrial protein import
Drugs
Diseases
GWAS		Macular telangiectasia type 2 ( 33654266) Metabolite levels ( 23823483 31628463) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259)	IgG N-glycosylation phenotypes (multivariate analysis) ( 32128391) Lymphocyte count ( 32888494)
Interacting Genes		30 interacting genes: ADAMTSL4 ADRA2C CHCHD10 CRYBA1 CTAG1A CTAG1B CYSRT1 EHMT2 FBXO7 GOLGA2 IKZF3 INCA1 KRT31 KRT40 LHX4 MIF4GD OIP5 P4HB PBX4 PLEKHF2 REL RNF144B TCF4 TRAF2 TREX1 TRIM42 TRIM54 TSC1 USP54 ZMYND12	2 interacting genes: CFTR CHCHD2
Entrez ID		51142	400916
HPRD ID		09879	12797
Ensembl ID		ENSG00000106153	ENSG00000250479
Uniprot IDs		Q9Y6H1	B5MBW9 Q8WYQ3
PDB IDs
Enriched GO Terms of Interacting Partners?		Identical Protein Binding	Positive Regulation Of Anion Channel Activity Positive Regulation Of Enamel Mineralization Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Cellular Response To Forskolin Response To Forskolin Chloride Transmembrane Transporter Activity Sperm Capacitation Regulation Of Cellular Response To Hypoxia Bicarbonate Transport Water Transport Multicellular Organismal-level Water Homeostasis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Ion Transmembrane Transporter Activity Cholesterol Biosynthetic Process 14-3-3 Protein Binding Fluid Transport Transepithelial Transport Vesicle Docking Involved In Exocytosis Positive Regulation Of Transporter Activity ABC-type Transporter Activity Sterol Biosynthetic Process Chloride Channel Complex Positive Regulation Of Biomineral Tissue Development Cellular Response To CAMP Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Vesicle Docking Regulation Of Cellular PH Regulation Of Transmembrane Transporter Activity Cholesterol Transport Membrane Docking Clathrin-coated Endocytic Vesicle Membrane Positive Regulation Of Exocytosis Cellular Response To Stress
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