RNF144B and DTNBP1

		RNF144B	DTNBP1
Description		ring finger protein 144B	dystrobrevin binding protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Mitochondrion Cytosol Membrane Organelle Membrane Mitochondrial Membrane	Nucleus Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Endosome Membrane Postsynaptic Density Microtubule Cytoskeleton Membrane Sarcoplasm Axon Growth Cone Midbody Cytoplasmic Vesicle Membrane Synaptic Vesicle Membrane BLOC-1 Complex Cytoplasmic Vesicle Asymmetric Synapse Melanosome Membrane Sarcolemma Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Postsynaptic Membrane Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse Axon Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Protein Ubiquitination Negative Regulation Of Apoptotic Process	Kidney Development Positive Regulation Of Neurotransmitter Secretion Positive Regulation Of Receptor Internalization Blood Coagulation Memory Anterograde Axonal Transport Regulation Of Signal Transduction Positive Regulation Of Gene Expression Regulation Of Dopamine Secretion Actin Cytoskeleton Organization Neuron Projection Development Melanosome Organization Anterograde Synaptic Vesicle Transport Neuron Projection Morphogenesis Dendrite Morphogenesis Retina Development In Camera-type Eye Platelet Dense Granule Organization Regulation Of Dopamine Receptor Signaling Pathway Cilium Assembly Negative Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Protein Transmembrane Transport Regulation Of Synaptic Vesicle Exocytosis
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Golgi Associated Vesicle Biogenesis
Drugs
Diseases			Hermansky-Pudlak syndrome (HPS)
GWAS		Adult body size ( 32376654) Age at voice drop ( 27182965) Appendicular lean mass ( 33097823) Caudal middle frontal gyrus volume ( 31530798) Chronic periodontitis (mean interproximal clinical attachment level) ( 27601451) Chronotype ( 30696823) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Endometriosis ( 23472165) Facial morphology ( 31763980) General risk tolerance (MTAG) ( 30643258) Gut microbiota relative abundance (Dorea) ( 33208821) Pulse pressure ( 30224653) Thiopurine S-methyltransferase activity ( 27770449) Triglyceride levels ( 32203549)	Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Corneal astigmatism ( 30306274) Femur bone mineral density x serum urate levels interaction ( 34046847) Liver enzyme levels (alkaline phosphatase) ( 33972514) Multiple myeloma ( 27363682) Serum alkaline phosphatase levels ( 33547301) Squamous cell carcinoma ( 31174203)
Interacting Genes		28 interacting genes: ANKS1A CDKN1A CHCHD2 CREB5 FOXH1 IL16 OTX1 PAN2 PAX5 PRKAB2 PROP1 PRR35 RIPPLY1 SGTA SGTB TRAF4 UBC UBE2I UBE2L3 UBE2L6 UBE2T UBE2U UBE2Z UBQLN1 USP15 USP2 VENTX ZIC1	51 interacting genes: ABI3 AKAP6 ARFIP2 BICRAL BLOC1S5 BLOC1S6 BRF1 CCDC146 CCNA2 CCND3 CMYA5 DCTN1 DGCR6L DRC12 DST DTNA DTNB ELOVL7 HAUS1 IFT20 IPO5 KALRN KANSL1 KIAA0408 KIFC3 KRT75 MACF1 NBEA NDN NECAB2 NUF2 OIP5 P4HA3 PSME3 RAB11A RBSN SDCBP SFR1 SHFL SNAPIN SRGAP3 SSC5D SYNE1 TNKS TRAF3IP1 TRIM2 TRIM27 TRIM9 VRK2 WASHC3 ZNF490
Entrez ID		255488	84062
HPRD ID		17126	06190
Ensembl ID		ENSG00000137393	ENSG00000047579
Uniprot IDs		Q7Z419	A0A087WYP9 A0A0S2Z5U8 A6NFV8 D6RJC6 Q96EV8
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Ubiquitin-like Protein Transferase Activity Nucleus Proteolysis Involved In Protein Catabolic Process Proteolysis TRC Complex Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Positive Regulation Of Metabolic Process Post-translational Protein Modification Positive Regulation Of Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Modification By Small Protein Conjugation Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of ERAD Pathway Pattern Specification Process Positive Regulation Of RNA Metabolic Process Protein Ubiquitination Cysteine-type Deubiquitinase Activity Regulation Of RNA Metabolic Process Regulation Of ERAD Pathway Catabolic Process Protein Binding Protein Modification Process Protein Targeting To ER Protein Polyubiquitination Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cyclin Binding Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Establishment Of Protein Localization To Endoplasmic Reticulum Diencephalon Morphogenesis SUMO Conjugating Enzyme Activity Negative Regulation Of Store-operated Calcium Channel Activity Protein Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Protein K11-linked Ubiquitination	Establishment Of Melanosome Localization Melanosome Localization Melanosome Transport Pigment Granule Transport Pigment Granule Localization Axonal Transport Microtubule-based Movement Transport Along Microtubule BLOC-1 Complex Anterograde Synaptic Vesicle Transport Axo-dendritic Transport Cytoskeleton-dependent Intracellular Transport Microtubule-based Process Microtubule-based Transport Establishment Of Vesicle Localization Axon Cytoplasm Microvesicle Vesicle Localization Endosome To Melanosome Transport Plasma Membrane Bounded Cell Projection Organization Synaptic Vesicle Transport Intracellular Transport Melanosome Organization Cellular Localization Nuclear Envelope Pigment Granule Organization Cell Projection Organization Anterograde Axonal Transport Organelle Organization Vesicle Transport Along Microtubule Cytoskeleton Organization Cytoplasm Microtubule Binding Nuclear Membrane Vesicle Cytoskeletal Trafficking Centrosome Establishment Of Protein Localization Cytoskeleton Secretion Of Lysosomal Enzymes Protein Transmembrane Transport Regulation Of Organelle Organization Establishment Of Localization In Cell Positive Regulation Of Pigment Cell Differentiation Spindle Pole Plasma Membrane Bounded Cell Projection Assembly Neuron Projection Development Organelle Transport Along Microtubule Regulation Of Actin Nucleation Cell Projection Assembly Protein Transport
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