H4C7 and KMT5C

Number of citations of the paper that reports this interaction (PubMedID 35907431)
0

Data Source:
BioGRID (enzymatic study)

		H4C7	KMT5C
Description		H4 clustered histone 7	lysine methyltransferase 5C
Image		No pdb structure
GO Annotations	Cellular Component	Nucleosome Nucleus Chromosome	Condensed Chromosome, Centromeric Region Heterochromatin Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin
	Molecular Function	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity	Chromatin Binding Protein Binding Methyltransferase Activity Transferase Activity Histone Binding Histone H4K20 Methyltransferase Activity Metal Ion Binding Histone H4 Methyltransferase Activity Histone H4K20me Methyltransferase Activity Histone H4K20 Monomethyltransferase Activity S-adenosyl-L-methionine Binding
	Biological Process	Nucleosome Assembly	DNA Repair Chromatin Organization Chromatin Remodeling Methylation Positive Regulation Of Isotype Switching Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways			PKMTs methylate histone lysines
Drugs
Diseases
GWAS
Interacting Genes		13 interacting genes: AGTRAP APOC1 CIDEB EP300 FGF14 FKBP7 KAT2A KAT8 KMT5B KMT5C MAIP1 RHBDD2 TMED8	5 interacting genes: H4C1 H4C7 RB1 RBL1 RBL2
Entrez ID		8369	84787
HPRD ID		11806	15454
Ensembl ID		ENSG00000275663	ENSG00000133247
Uniprot IDs		Q99525	A0A0D9SF94 Q86Y97
PDB IDs			3RQ4
Enriched GO Terms of Interacting Partners?		Histone Acetyltransferase Complex Protein Propionyltransferase Activity Protein-lysine-acetyltransferase Activity Acetyltransferase Activity Histone H3K18 Acetyltransferase Activity Histone Acetyltransferase Activity Histone H4K20me Methyltransferase Activity Histone H4K20 Monomethyltransferase Activity Histone H4 Methyltransferase Activity Histone H4K20 Methyltransferase Activity Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Very-low-density Lipoprotein Particle Assembly Histone H4 Acetyltransferase Activity Peptidyl-lysine Acetylation Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Small Molecule Metabolic Process Chromatin Remodeling Condensed Chromosome, Centromeric Region Negative Regulation Of Gluconeogenesis Chromosome Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains S-adenosyl-L-methionine Binding Positive Regulation Of Adaptive Immune Response Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Acyltransferase Activity Positive Regulation Of Isotype Switching Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Protein Acetylation DNA-binding Transcription Factor Binding Chromatin Binding Regulation Of Isotype Switching Regulation Of Triglyceride Metabolic Process Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Immunoglobulin Mediated Immune Response Negative Regulation Of Phosphatidylcholine Catabolic Process Positive Regulation Of Gene Expression, Epigenetic Somitogenesis Peptidyl-lysine Propionylation Segmentation Regulation Of Lymphocyte Activation Swimming Histone Lactyltransferase (CoA-dependent) Activity Gluconeogenesis Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity	Regulation Of Lipid Kinase Activity Chromatin Organization Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Transcription Regulator Complex Regulation Of Kinase Activity Negative Regulation Of Cell Cycle Process Protein Localization To Chromosome, Centromeric Region Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Phosphorylation Regulation Of Cell Cycle Phase Transition Promoter-specific Chromatin Binding Regulation Of Mitotic Cell Cycle Structural Constituent Of Chromatin Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Protein Localization To Chromosome Nucleosome Assembly Nucleosome Chromatin Remodeling Chromosome Nucleosome Organization Regulation Of Cell Cycle Process Chromatin Lock Complex DNA Binding Sister Chromatid Biorientation Maintenance Of Mitotic Sister Chromatid Cohesion Positive Regulation Of Collagen Fibril Organization Protein-DNA Complex Assembly Glial Cell Apoptotic Process Rb-E2F Complex Regulation Of Myeloid Cell Differentiation Negative Regulation Of Myofibroblast Differentiation Negative Regulation Of Hepatocyte Apoptotic Process Regulation Of Centromere Complex Assembly Enucleate Erythrocyte Differentiation Regulation Of Cell Cycle Chromatin Cyclin/CDK Positive Transcription Elongation Factor Complex Negative Regulation Of Gene Expression Regulation Of Myofibroblast Differentiation Regulation Of Collagen Fibril Organization Importin-alpha Family Protein Binding
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