DENND1A

Description		DENN domain containing 1A
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Lipid Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Phosphate Binding
	Biological Process	Endocytosis Protein Transport Endocytic Recycling Regulation Of Rab Protein Signal Transduction
Pathways		RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145) Body mass index ( 26426971) Body mass index in non-asthmatics ( 23517042) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Depression ( 29700475) Feeling nervous ( 29500382) Femur bone mineral density x serum urate levels interaction ( 34046847) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Macular thickness ( 30535121) Major depressive disorder ( 27479909) Myopia (pathological) ( 23049088) Personality dimensions ( 20691247) Polycystic ovary syndrome ( 21151128 30566500 26416764 26284813) Polycystic ovary syndrome (adjusted for age and BMI) ( 34791234) Polycystic ovary syndrome (adjusted for age) ( 34791234) Rheumatoid arthritis ( 30891314) Self-reported risk-taking behaviour ( 30271922) Suffering from nerves ( 29500382) Tea consumption ( 31046077) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Waist circumference ( 23966867)
Interacting Genes		4 interacting genes: ARF1 ARF4 ARF5 PCM1
Entrez ID		57706
HPRD ID		17221
Ensembl ID		ENSG00000119522
Uniprot IDs		A0A0A0MS48 Q8TEH3 Q9HCG4
PDB IDs		6EKK
Enriched GO Terms of Interacting Partners?		GTPase Activity Cellular Localization GTP Binding Establishment Of Localization In Cell Intracellular Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intracellular Protein Localization Intracellular Protein Transport Mitotic Cleavage Furrow Ingression Cleavage Furrow Ingression Phospholipase D Activator Activity Protein-containing Complex Localization To Centriolar Satellite Plasma Membrane Bounded Cell Projection Organization Protein Transport Cell Projection Organization Interkinetic Nuclear Migration Vesicle-mediated Transport Establishment Of Protein Localization NAD+-protein-arginine ADP-ribosyltransferase Activity Cilium Assembly Golgi Vesicle Transport Intraciliary Transport Involved In Cilium Assembly Golgi Apparatus Cilium Organization Plasma Membrane Bounded Cell Projection Assembly Microtubule Anchoring At Centrosome Cell Projection Assembly Microtubule Anchoring At Microtubule Organizing Center Nucleotide Binding Intracellular Copper Ion Homeostasis Long-term Synaptic Depression Apical Protein Localization Dendritic Spine Development Regulation Of Protein Complex Stability Copper Ion Homeostasis Pericentriolar Material Neuronal Stem Cell Population Maintenance Mitotic Cytokinetic Process Regulation Of Arp2/3 Complex-mediated Actin Nucleation Extracellular Exosome Microtubule Anchoring Protein Localization To Centrosome Nuclear Migration Nucleus Localization Non-motile Cilium Golgi Membrane Dendritic Spine Organization Epidermal Growth Factor Receptor Binding Protein Localization To Organelle Ciliary Transition Zone
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