TTC8

Description		tetratricopeptide repeat domain 8
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GO Annotations	Cellular Component	Fibrillar Center Cytoplasm Mitochondrion Centrosome Cytosol Cytoskeleton Plasma Membrane Cilium Membrane Photoreceptor Connecting Cilium Centriolar Satellite BBSome Ciliary Basal Body Cell Projection Ciliary Membrane Non-motile Cilium
	Molecular Function	Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Establishment Of Planar Polarity Axon Guidance Sensory Perception Sensory Perception Of Smell Anatomical Structure Morphogenesis Protein Transport Olfactory Bulb Development Cell Projection Organization Regulation Of Protein Localization Multicellular Organism Growth Establishment Of Epithelial Cell Apical/basal Polarity Fat Cell Differentiation Establishment Of Anatomical Structure Orientation Sensory Processing Regulation Of Stress Fiber Assembly Inner Ear Receptor Cell Stereocilium Organization Camera-type Eye Photoreceptor Cell Differentiation Cilium Assembly Renal Tubule Development Protein Localization To Plasma Membrane Multi-ciliated Epithelial Cell Differentiation Non-motile Cilium Assembly
Pathways		BBSome-mediated cargo-targeting to cilium
Drugs
Diseases		Bardet-Biedl syndrome (BBS)
GWAS		Copper levels ( 26025379) Limited cutaneous systemic scleroderma ( 29293537) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Obesity-related traits ( 23251661) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Novel Interacting Genes		1 novel interacting genes: PTPN21
Interacting Genes		1 interacting genes: PCM1
Entrez ID		123016
HPRD ID		10484
Ensembl ID		ENSG00000165533
Uniprot IDs		A0A0C4DGH8 A0A0C4DGX9 A0A0C4DGY3 B3KSL8 Q86U25 Q8TAM2
PDB IDs		6XT9
Enriched GO Terms of Interacting Partners?		Interkinetic Nuclear Migration Protein-containing Complex Localization To Centriolar Satellite Intraciliary Transport Involved In Cilium Assembly Regulation Of Protein Complex Stability Microtubule Anchoring At Centrosome Pericentriolar Material Nucleus Localization Ciliary Transition Zone Microtubule Anchoring Neuronal Stem Cell Population Maintenance Non-motile Cilium Protein Localization To Centrosome Microtubule Anchoring At Microtubule Organizing Center Nuclear Migration Non-motile Cilium Assembly Protein Localization To Cytoskeleton Centrosome Cycle Social Behavior Intraciliary Transport Cytoplasmic Microtubule Organization Cytoskeleton Protein-containing Complex Localization Microtubule Organizing Center Organization Apical Part Of Cell Positive Regulation Of Intracellular Protein Transport Protein Dephosphorylation
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