TTC8 and PCM1

Number of citations of the paper that reports this interaction (PubMedID 14520415)
0

Data Source:
HPRD (in vivo)

		TTC8	PCM1
Description		tetratricopeptide repeat domain 8	pericentriolar material 1
Image
GO Annotations	Cellular Component	Fibrillar Center Cytoplasm Mitochondrion Centrosome Cytosol Cytoskeleton Plasma Membrane Cilium Membrane Photoreceptor Connecting Cilium Centriolar Satellite BBSome Ciliary Basal Body Cell Projection Ciliary Membrane Non-motile Cilium	Pericentriolar Material Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cilium Microtubule Cytoskeleton Membrane Nuclear Membrane Protein-containing Complex Centriolar Satellite Ciliary Transition Zone Ciliary Basal Body Cell Projection Apical Part Of Cell Non-motile Cilium
	Molecular Function	Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Protein Binding Identical Protein Binding Molecular Adaptor Activity
	Biological Process	Establishment Of Planar Polarity Axon Guidance Sensory Perception Sensory Perception Of Smell Anatomical Structure Morphogenesis Protein Transport Olfactory Bulb Development Cell Projection Organization Regulation Of Protein Localization Multicellular Organism Growth Establishment Of Epithelial Cell Apical/basal Polarity Fat Cell Differentiation Establishment Of Anatomical Structure Orientation Sensory Processing Regulation Of Stress Fiber Assembly Inner Ear Receptor Cell Stereocilium Organization Camera-type Eye Photoreceptor Cell Differentiation Cilium Assembly Renal Tubule Development Protein Localization To Plasma Membrane Multi-ciliated Epithelial Cell Differentiation Non-motile Cilium Assembly	Neuron Migration Centrosome Cycle Interkinetic Nuclear Migration Cell Projection Organization Cytoplasmic Microtubule Organization Protein Localization To Organelle Microtubule Anchoring Microtubule Anchoring At Centrosome Social Behavior Intraciliary Transport Involved In Cilium Assembly Negative Regulation Of Neurogenesis Cilium Assembly Regulation Of Protein Complex Stability Protein Localization To Centrosome Positive Regulation Of Intracellular Protein Transport Neuronal Stem Cell Population Maintenance Protein-containing Complex Localization To Centriolar Satellite Non-motile Cilium Assembly
Pathways		BBSome-mediated cargo-targeting to cilium	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases		Bardet-Biedl syndrome (BBS)
GWAS		Copper levels ( 26025379) Limited cutaneous systemic scleroderma ( 29293537) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Obesity-related traits ( 23251661) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Atrial fibrillation ( 28416818) Economic and political preferences ( 22566634) Heel bone mineral density x serum urate levels interaction ( 34046847) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Triglyceride levels ( 32203549) Waist-hip ratio ( 30108283) Weight ( 28552196)
Interacting Genes		1 interacting genes: PCM1	57 interacting genes: ABI1 ABI2 AKAP9 ALG13 APP BACE2 BBS4 BICD2 CASK CCHCR1 CDC42 CDK1 CEBPA CEP72 CYTH4 DDIT3 DDX23 DENND1A DYNLL1 E2F4 ECPAS EPS8 EXOC8 FAM81A FXR2 GABARAP GOLGA2 GRN HAP1 ING5 INTS4 KAT5 KLC1 KLC4 KRT15 KRT19 KRT24 LARP4 LSM2 MCRS1 MORF4L1 NDUFA9 PCNT PPIE PRC1 PRKCI PRPF6 RALBP1 RBM11 RBM5 RINT1 RPA2 TFIP11 TTC8 VPS26C WASHC3 ZNF830
Entrez ID		123016	5108
HPRD ID		10484	02624
Ensembl ID		ENSG00000165533	ENSG00000078674
Uniprot IDs		A0A0C4DGH8 A0A0C4DGX9 A0A0C4DGY3 B3KSL8 Q86U25 Q8TAM2	A0A4W8VX11 A0A5H1ZRS1 A2RUU9 B9EIS5 E9PGW9 Q15154
PDB IDs		6XT9	6HYL 6HYM 7Q46
Enriched GO Terms of Interacting Partners?		Interkinetic Nuclear Migration Protein-containing Complex Localization To Centriolar Satellite Intraciliary Transport Involved In Cilium Assembly Regulation Of Protein Complex Stability Microtubule Anchoring At Centrosome Pericentriolar Material Nucleus Localization Ciliary Transition Zone Microtubule Anchoring Neuronal Stem Cell Population Maintenance Non-motile Cilium Protein Localization To Centrosome Microtubule Anchoring At Microtubule Organizing Center Nuclear Migration Non-motile Cilium Assembly Protein Localization To Cytoskeleton Centrosome Cycle Social Behavior Intraciliary Transport Cytoplasmic Microtubule Organization Cytoskeleton Protein-containing Complex Localization Microtubule Organizing Center Organization Apical Part Of Cell Positive Regulation Of Intracellular Protein Transport Protein Dephosphorylation	Cytoskeleton Organelle Organization Cytoskeleton Organization Microtubule-based Process Centrosome Supramolecular Fiber Organization Positive Regulation Of Organelle Organization Cytosol Spliceosomal Complex Microtubule Cytoskeleton Organization Centriolar Satellite Regulation Of Supramolecular Fiber Organization Growth Cone Microtubule Organizing Center Organization Regulation Of Organelle Organization Catalytic Step 2 Spliceosome Cellular Component Assembly Regulation Of Cell Cycle Cellular Response To Stress Microtubule Intracellular Protein Localization Positive Regulation Of Cellular Component Organization Establishment Of Protein Localization CHOP-C/EBP Complex Regulation Of Actin Filament Organization RNA Splicing Cytoplasm Cellular Localization Astrocyte Activation Involved In Immune Response Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Sensory Processing Regulation Of Attachment Of Spindle Microtubules To Kinetochore Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity MRNA Splicing, Via Spliceosome Histone Acetyltransferase Complex Epithelial Cell Differentiation Protein Transport Mitotic DNA Damage Checkpoint Signaling Regulation Of Cytoskeleton Organization RNA Splicing, Via Transesterification Reactions Mitotic DNA Integrity Checkpoint Signaling Positive Regulation Of Protein Metabolic Process Mitotic Spindle Microtubule Nucleation MRNA Processing Golgi Disassembly Nuclear DNA Replication Organelle Disassembly
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