TMED5 and DCTN1

		TMED5	DCTN1
Description		transmembrane p24 trafficking protein 5	dynactin subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Membrane COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Endoplasmic Reticulum Exit Site	Kinetochore Spindle Pole Nucleus Nuclear Envelope Cytoplasm Centrosome Centriole Spindle Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Cilium Cell Cortex Microtubule Cytoskeleton Membrane Dynein Complex Axon Retromer Complex Cell Leading Edge Protein-containing Complex Microtubule Plus-end Ciliary Basal Body Neuron Projection Neuronal Cell Body Intercellular Bridge Mitotic Spindle Cell Cortex Region Centriolar Subdistal Appendage
	Molecular Function	Protein Binding	Protein Binding Microtubule Binding Tubulin Binding Protein Kinase Binding Tau Protein Binding
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Golgi Ribbon Formation	Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Nuclear Migration Nervous System Development Neuromuscular Junction Development Centriole-centriole Cohesion Ventral Spinal Cord Development Positive Regulation Of Microtubule Polymerization Melanosome Transport Microtubule Anchoring At Centrosome Retrograde Transport, Endosome To Golgi Neuromuscular Process Nuclear Membrane Disassembly Cell Division Regulation Of Mitotic Spindle Organization Motor Behavior Neuron Cellular Homeostasis Positive Regulation Of Microtubule Nucleation Axonal Transport Maintenance Of Synapse Structure Positive Regulation Of Neuromuscular Junction Development Non-motile Cilium Assembly Neuron Projection Maintenance
Pathways		WNT ligand biogenesis and trafficking	MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand XBP1(S) activates chaperone genes COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Signaling by ALK fusions and activated point mutants
Drugs
Diseases			Perry syndrome Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Distal hereditary motor neuropathies (dHMN)
GWAS		High density lipoprotein cholesterol levels ( 29403010)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Refractive error ( 32231278)
Interacting Genes		3 interacting genes: CXCL9 PRMT6 TMEM132D	52 interacting genes: ACTR1A ACTR1B AKT1 APEX1 BBS1 BBS4 BICD1 BICD2 CASP2 CASP3 CASP7 CDC37 CLIP1 CTIF DCTN3 DISC1 DST DTNBP1 DYNC1I1 DYNC1I2 EEF1A1 ENO3 FBXL5 FXR1 GRB2 GSK3B HAP1 HOXA1 HSPB2 KIAA0408 KIF11 LCOR MAP2K3 MAP2K6 MAPRE1 MED14 MTERF1 NEK2 NOD2 PAFAH1B1 PFDN1 PGAM1 PPP1CA RAB6A RBL2 RPGR SEC23A SPTBN2 STAT1 TP53RK VIM ZNF512B
Entrez ID		50999	1639
HPRD ID		13028	07206
Ensembl ID		ENSG00000117500	ENSG00000204843
Uniprot IDs		M0R072 Q9Y3A6	A0A7P0Z4C3 Q14203
PDB IDs			1TXQ 2COY 2HKN 2HKQ 2HL3 2HL5 2HQH 3E2U 3TQ7
Enriched GO Terms of Interacting Partners?		Cell Cortex Region Positive Regulation Of Neuromuscular Junction Development TRNA 2'-O-methyltransferase Activity Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Histone Arginine N-methyltransferase Activity Negative Regulation Of Sodium Ion Import Across Plasma Membrane Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Intracellular Cholesterol Transport Negative Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport Low-density Lipoprotein Receptor Particle Metabolic Process Extrinsic Component Of External Side Of Plasma Membrane PCSK9-AnxA2 Complex Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process PCSK9-LDLR Complex CXCR3 Chemokine Receptor Binding Methyltransferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Histone H4R3 Methyltransferase Activity Very-low-density Lipoprotein Particle Binding Negative Regulation Of Receptor Recycling Very-low-density Lipoprotein Particle Receptor Binding Apolipoprotein Receptor Binding Positive Regulation Of Microtubule Nucleation Centriolar Subdistal Appendage Ventral Spinal Cord Development TRNA Methyltransferase Activity Methylation Protein-arginine N-methyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Sodium Channel Inhibitor Activity Positive Regulation Of Receptor Catabolic Process Regulation Of Intracellular Cholesterol Transport Regulation Of Intracellular Lipid Transport Signaling Receptor Inhibitor Activity Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Sodium Ion Transmembrane Transport	Cytosol Centrosome Microtubule-based Process Transport Along Microtubule Cytoskeleton Cytoskeleton-dependent Intracellular Transport Dynactin Binding Microtubule-based Transport Cytoplasm Organelle Transport Along Microtubule Microtubule-based Movement Cytoskeleton Organization Organelle Organization Minus-end-directed Organelle Transport Along Microtubule Protein Kinase Binding Regulation Of Microtubule-based Process Microtubule Cytoskeleton Organization Establishment Of Organelle Localization Microtubule Plus-end Binding Microtubule Organizing Center Execution Phase Of Apoptosis Microtubule Cell Cortex Dynactin Complex Organelle Assembly Hippocampus Development Positive Regulation Of Cilium Assembly Axon Ciliary Basal Body Response To Light Stimulus Microtubule Anchoring At Microtubule Organizing Center Positive Regulation Of Cellular Component Organization Response To Radiation Pyroptotic Inflammatory Response Perinuclear Region Of Cytoplasm Vesicle Transport Along Microtubule Regulation Of Microtubule Cytoskeleton Organization Organelle Localization Microtubule Cytoskeleton Establishment Of Vesicle Localization Non-motile Cilium Assembly Protein Binding Central Region Of Growth Cone Vesicle Cytoskeletal Trafficking Brain Morphogenesis Dynein Complex Binding Retrograde Axonal Transport Vesicle Localization Protein Localization To Cilium Regulation Of Cytoskeleton Organization
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?